BACE1 Produits
(Beta-secretase 1 (BACE1))
Catégories
Cerebral deposition of amyloid beta peptide is an early and critical feature of Alzheimer's disease. Amyloid beta peptide is generated by proteolytic cleavage of amyloid precursor protein (APP) by two proteases, one of which is the protein encoded by this gene. The encoded protein, a member of the peptidase A1 protein family, is a type I integral membrane glycoprotein and aspartic protease that is found mainly in the Golgi. Multiple transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, May 2011].
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Catégories BACE1 en vedette
BACE1 Anticorps
High quality antibodies with extensive validation data.
BACE1 Kits ELISA
Reliable ELISA kits for a wide range of species.
BACE1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BACE1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, ICC, FACS
Validations
- (6)
N° du produit
ABIN2682977
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), PLA
Validations
- (6)
N° du produit
ABIN2566113
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC, IF
Validations
- (6)
N° du produit
ABIN2782766
Quantité
100 μL
Fiche technique
Fiche technique
BACE1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6954088
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6963107
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965161
Quantité
96 tests
Fiche technique
Fiche technique
BACE1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7273905
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7273904
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (2)
N° du produit
ABIN7273906
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BACE1
: "Inhibition of BACE1, the β-secretase implicated in Alzheimer's disease, by a chondroitin sulfate extract from Sardina pilchardus." dans: Neural regeneration research, Vol. 15, Issue 8, pp. 1546-1553, (2020) (PubMed).: "NF-κB-regulated microRNA-574-5p underlies synaptic and cognitive impairment in response to atmospheric PM2.5 aspiration." dans: Particle and fibre toxicology, Vol. 14, Issue 1, pp. 34, (2018) (PubMed).
: "Comparative study of the effects of phosphatidylcholine rich in DHA and EPA on Alzheimer's disease and the possible mechanisms in CHO-APP/PS1 cells and SAMP8 mice." dans: Food & function, Vol. 9, Issue 1, pp. 643-654, (2018) (PubMed).
: "Thymoquinone-rich fraction nanoemulsion (TQRFNE) decreases Aβ40 and Aβ42 levels by modulating APP processing, up-regulating IDE and LRP1, and down-regulating BACE1 and RAGE in response to high ..." dans: Biomedicine & pharmacotherapy, Vol. 95, pp. 780-788, (2018) (PubMed).
: "An Anti-Parkinson's Disease Drug via Targeting Adenosine A2A Receptor Enhances Amyloid-β Generation and γ-Secretase Activity." dans: PLoS ONE, Vol. 11, Issue 11, pp. e0166415, (2017) (PubMed).
: "Dopamine D2 receptor and β-arrestin 2 mediate Amyloid-β elevation induced by anti-parkinson's disease drugs, levodopa and piribedil, in neuronal cells." dans: PLoS ONE, Vol. 12, Issue 3, pp. e0173240, (2017) (PubMed).
: "Effects of RAGE-Specific Inhibitor FPS-ZM1 on Amyloid-β Metabolism and AGEs-Induced Inflammation and Oxidative Stress in Rat Hippocampus." dans: Neurochemical research, Vol. 41, Issue 5, pp. 1192-9, (2016) (PubMed).
: "NO2 inhalation promotes Alzheimer's disease-like progression: cyclooxygenase-2-derived prostaglandin E2 modulation and monoacylglycerol lipase inhibition-targeted medication." dans: Scientific reports, Vol. 6, pp. 22429, (2016) (PubMed).
: "Osthole decreases beta amyloid levels through up-regulation of miR-107 in Alzheimer's disease." dans: Neuropharmacology, Vol. 108, pp. 332-44, (2016) (PubMed).
: "Cyclic cis-Locked Phospho-Dipeptides Reduce Entry of AβPP into Amyloidogenic Processing Pathway." dans: Journal of Alzheimer's disease : JAD, Vol. 55, Issue 1, pp. 391-410, (2016) (PubMed).
Synonymes et noms alternatifs relatifs à BACE1
beta-secretase 1 (BACE1), beta-site APP cleaving enzyme 1 (Bace1), beta-secretase 1 (Bace1), beta-site APP-cleaving enzyme 1 (bace1), ASP2, BACE, Bace, BACE1, C76936, HSPC104, MGC145931, zgc:77409Protein level used designations for BACE1
- APP beta-secretase
- asp 2
- aspartyl protease 2
- beta-secretase 1
- beta-secretase 1 precursor variant 1
- beta-site APP cleaving enzyme 1
- beta-site amyloid beta A4 precursor protein-cleaving enzyme
- memapsin-2
- membrane-associated aspartic protease 2
- transmembrane aspartic proteinase Asp2
- ASP2
- beta-site amyloid precursor protein cleaving enzyme 1
- beta-site APP cleaving enzyme
- beta secretase 1
- beta-secretase 1 isoform A preproprotein
- beta-secretase 1 isoform B preproprotein
- beta-secretase 1 isoform C preproprotein
- beta-site APP-cleaving enzyme 1
- beta-secretase 1-like
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