BARD1 Produits
(BRCA1 Associated RING Domain 1 (BARD1))
Catégories
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq, Jul 2008].
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Catégories BARD1 en vedette
BARD1 Anticorps
High quality antibodies with extensive validation data.
BARD1 Kits ELISA
Reliable ELISA kits for a wide range of species.
BARD1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BARD1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (1)
- (1)
N° du produit
ABIN706496
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IF
Validations
- (2)
N° du produit
ABIN560033
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (1)
N° du produit
ABIN7188551
Quantité
100 μg
Fiche technique
Fiche technique
BARD1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1124118
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1124119
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1124120
Quantité
96 tests
Fiche technique
Fiche technique
BARD1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346405
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3132003
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3089922
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits BARD1
: "FOXK2 transcription factor suppresses ER?-positive breast cancer cell growth through down-regulating the stability of ER? via mechanism involving BRCA1/BARD1." dans: Scientific reports, Vol. 5, pp. 8796, (2015) (PubMed).: "The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function." dans: Cellular signalling, Vol. 27, Issue 9, pp. 1763-71, (2015) (PubMed).
: "Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer." dans: Breast cancer research and treatment, Vol. 145, Issue 2, pp. 317-30, (2014) (PubMed).
: "SUMOylation proteins in breast cancer." dans: Breast cancer research and treatment, Vol. 144, Issue 3, pp. 519-30, (2014) (PubMed).
: "Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. ..." dans: Cancer research, Vol. 72, Issue 8, pp. 2068-78, (2012) (PubMed).
: "The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci." dans: Traffic (Copenhagen, Denmark), Vol. 13, Issue 6, pp. 800-14, (2012) (PubMed).
: "Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome." dans: British journal of cancer, Vol. 107, Issue 4, pp. 675-83, (2012) (PubMed).
: "BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair." dans: Journal of cell science, Vol. 125, Issue Pt 15, pp. 3529-34, (2012) (PubMed).
: "HERC2 is an E3 ligase that targets BRCA1 for degradation." dans: Cancer research, Vol. 70, Issue 15, pp. 6384-92, (2010) (PubMed).
: "Transcriptional autoregulation by BRCA1." dans: Cancer research, Vol. 70, Issue 2, pp. 532-42, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à BARD1
BRCA1 associated RING domain 1 (BARD1), BRCA1 associated RING domain 1 (bard1), BRCA1 associated RING domain 1 (Bard1), BARD1, ENSMUSG00000060893, ENSMUSG00000073653, LOC100147913Protein level used designations for BARD1
- BRCA1 associated RING domain 1
- BRCA1-associated RING domain protein 1-like
- BRCA1 associated RING domain 1 isoform alfa
- BRCA1 associated RING domain 1 isoform beta
- BRCA1 associated RING domain 1 isoform delta
- BRCA1 associated RING domain 1 isoform epsilon
- BRCA1 associated RING domain 1 isoform eta
- BRCA1 associated RING domain 1 isoform gamma
- BRCA1 associated RING domain 1 isoform phi
- BRCA1-associated RING domain gene 1
- BRCA1-associated RING domain protein 1
- BARD-1
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