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BARD1 Produits

(BRCA1 Associated RING Domain 1 (BARD1))
This gene encodes a protein which interacts with the N-terminal region of BRCA1. In addition to its ability to bind BRCA1 in vivo and in vitro, it shares homology with the 2 most conserved regions of BRCA1: the N-terminal RING motif and the C-terminal BRCT domain. The RING motif is a cysteine-rich sequence found in a variety of proteins that regulate cell growth, including the products of tumor suppressor genes and dominant protooncogenes. This protein also contains 3 tandem ankyrin repeats. The BARD1/BRCA1 interaction is disrupted by tumorigenic amino acid substitutions in BRCA1, implying that the formation of a stable complex between these proteins may be an essential aspect of BRCA1 tumor suppression. This protein may be the target of oncogenic mutations in breast or ovarian cancer. [provided by RefSeq, Jul 2008].

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Catégories BARD1 en vedette

BARD1 Anticorps

High quality antibodies with extensive validation data.

BARD1 Kits ELISA

Reliable ELISA kits for a wide range of species.

BARD1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

BARD1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, ELISA, FACS, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (1)
  • (1)
N° du produit ABIN706496
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IF
Validations
  • (2)
N° du produit ABIN560033
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC
Validations
  • (1)
N° du produit ABIN7188551
Quantité 100 μg
Fiche technique Fiche technique

BARD1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1124118
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1124119
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method
Validations
N° du produit ABIN1124120
Quantité 96 tests
Fiche technique Fiche technique

BARD1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1346405
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3132003
Quantité 1 mg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3089922
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits BARD1

Liu, Ao, Jia, Bai, Xu, Hu, Jiang, Chen, Wu: "FOXK2 transcription factor suppresses ER?-positive breast cancer cell growth through down-regulating the stability of ER? via mechanism involving BRCA1/BARD1." dans: Scientific reports, Vol. 5, pp. 8796, (2015) (PubMed).

Tembe, Martino-Echarri, Marzec, Mok, Brodie, Mills, Lei, DeFazio, Rizos, Kettle, Boadle, Henderson: "The BARD1 BRCT domain contributes to p53 binding, cytoplasmic and mitochondrial localization, and apoptotic function." dans: Cellular signalling, Vol. 27, Issue 9, pp. 1763-71, (2015) (PubMed).

Jerjees, Alabdullah, Green, Alshareeda, Macmillan, Ellis, Rakha: "Prognostic and biological significance of proliferation and HER2 expression in the luminal class of breast cancer." dans: Breast cancer research and treatment, Vol. 145, Issue 2, pp. 317-30, (2014) (PubMed).

Alshareeda, Negm, Green, Nolan, Tighe, Albarakati, Sultana, Madhusudan, Ellis, Rakha: "SUMOylation proteins in breast cancer." dans: Breast cancer research and treatment, Vol. 144, Issue 3, pp. 519-30, (2014) (PubMed).

Bosse, Diskin, Cole, Wood, Schnepp, Norris, Nguyen, Jagannathan, Laquaglia, Winter, Diamond, Hou, Attiyeh, Mosse, Pineros, Dizin, Zhang, Asgharzadeh, Seeger, Capasso, Pawel, Devoto, Hakonarson et al.: "Common variation at BARD1 results in the expression of an oncogenic isoform that influences neuroblastoma susceptibility and oncogenicity. ..." dans: Cancer research, Vol. 72, Issue 8, pp. 2068-78, (2012) (PubMed).

Mok, Henderson: "The in vivo dynamic organization of BRCA1-A complex proteins at DNA damage-induced nuclear foci." dans: Traffic (Copenhagen, Denmark), Vol. 13, Issue 6, pp. 800-14, (2012) (PubMed).

Zhang, Pilyugin, Kuester, Leoni, Li, Casula, Zorcolo, Schneider-Stock, Atzori, Irminger-Finger: "Expression of oncogenic BARD1 isoforms affects colon cancer progression and correlates with clinical outcome." dans: British journal of cancer, Vol. 107, Issue 4, pp. 675-83, (2012) (PubMed).

Chapman, Sossick, Boulton, Jackson: "BRCA1-associated exclusion of 53BP1 from DNA damage sites underlies temporal control of DNA repair." dans: Journal of cell science, Vol. 125, Issue Pt 15, pp. 3529-34, (2012) (PubMed).

Wu, Sato, Koike, Nishikawa, Koizumi, Venkitaraman, Ohta: "HERC2 is an E3 ligase that targets BRCA1 for degradation." dans: Cancer research, Vol. 70, Issue 15, pp. 6384-92, (2010) (PubMed).

De Siervi, De Luca, Byun, Di, Fufa, Haggerty, Vazquez, Moiola, Longo, Gardner: "Transcriptional autoregulation by BRCA1." dans: Cancer research, Vol. 70, Issue 2, pp. 532-42, (2010) (PubMed).

Synonymes et noms alternatifs relatifs à BARD1

BRCA1 associated RING domain 1 (BARD1), BRCA1 associated RING domain 1 (bard1), BRCA1 associated RING domain 1 (Bard1), BARD1, ENSMUSG00000060893, ENSMUSG00000073653, LOC100147913

Protein level used designations for BARD1

  • BRCA1 associated RING domain 1
  • BRCA1-associated RING domain protein 1-like
  • BRCA1 associated RING domain 1 isoform alfa
  • BRCA1 associated RING domain 1 isoform beta
  • BRCA1 associated RING domain 1 isoform delta
  • BRCA1 associated RING domain 1 isoform epsilon
  • BRCA1 associated RING domain 1 isoform eta
  • BRCA1 associated RING domain 1 isoform gamma
  • BRCA1 associated RING domain 1 isoform phi
  • BRCA1-associated RING domain gene 1
  • BRCA1-associated RING domain protein 1
  • BARD-1
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