BCL11A Produits
(B-Cell CLL/lymphoma 11A (Zinc Finger Protein) (BCL11A))
Catégories
This gene encodes a C2H2 type zinc-finger protein by its similarity to the mouse Bcl11a/Evi9 protein. The corresponding mouse gene is a common site of retroviral integration in myeloid leukemia, and may function as a leukemia disease gene, in part, through its interaction with BCL6. During hematopoietic cell differentiation, this gene is down-regulated. It is possibly involved in lymphoma pathogenesis since translocations associated with B-cell malignancies also deregulates its expression. Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
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Catégories BCL11A en vedette
BCL11A Anticorps
High quality antibodies with extensive validation data.
BCL11A Kits ELISA
Reliable ELISA kits for a wide range of species.
BCL11A Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BCL11A recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (5)
N° du produit
ABIN526947
Quantité
100 μg
Fiche technique
Fiche technique
Application
WB, IHC, IHC (p)
Validations
- (4)
N° du produit
ABIN6741578
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7145171
Quantité
100 μL
Fiche technique
Fiche technique
BCL11A recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954027
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6223083
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1123168
Quantité
96 tests
Fiche technique
Fiche technique
BCL11A recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346538
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346540
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7407040
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BCL11A
: "A natural regulatory mutation in the proximal promoter elevates fetal globin expression by creating a de novo GATA1 site." dans: Blood, Vol. 133, Issue 8, pp. 852-856, (2019) (PubMed).: "Natural regulatory mutations elevate the fetal globin gene via disruption of BCL11A or ZBTB7A binding." dans: Nature genetics, Vol. 50, Issue 4, pp. 498-503, (2018) (PubMed).
: "Bcl11a controls Flt3 expression in early hematopoietic progenitors and is required for pDC development in vivo." dans: PLoS ONE, Vol. 8, Issue 5, pp. e64800, (2013) (PubMed).
: "Transcriptional silencing of {gamma}-globin by BCL11A involves long-range interactions and cooperation with SOX6." dans: Genes & development, Vol. 24, Issue 8, pp. 783-98, (2010) (PubMed).
: "BCL11A represses HBG transcription in K562 cells." dans: Blood cells, molecules & diseases, Vol. 42, Issue 2, pp. 144-9, (2009) (PubMed).
: "Genome-wide association study shows BCL11A associated with persistent fetal hemoglobin and amelioration of the phenotype of beta-thalassemia." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 5, pp. 1620-5, (2008) (PubMed).
: "Novel markers of normal and neoplastic human plasmacytoid dendritic cells." dans: Blood, Vol. 111, Issue 7, pp. 3778-92, (2008) (PubMed).
: "Functional studies of BCL11A: characterization of the conserved BCL11A-XL splice variant and its interaction with BCL6 in nuclear paraspeckles of germinal center B cells." dans: Molecular cancer, Vol. 5, pp. 18, (2006) (PubMed).
: "The BCL11AXL transcription factor: its distribution in normal and malignant tissues and use as a marker for plasmacytoid dendritic cells." dans: Leukemia, Vol. 20, Issue 8, pp. 1439-41, (2006) (PubMed).
: "Hydroxyurea differentially modulates activator and repressors of γ-globin gene in erythroblasts of responsive and non-responsive patients with sickle cell disease in correlation with Index of ..." dans: Haematologica, Vol. 102, Issue 12, pp. 1995-2004 (PubMed).
Synonymes et noms alternatifs relatifs à BCL11A
B cell CLL/lymphoma 11A (zinc finger protein) (Bcl11a), B-cell CLL/lymphoma 11A (BCL11A), B-cell CLL/lymphoma 11A L homeolog (bcl11a.L), B-cell CLL/lymphoma 11A (Bcl11a), B-cell CLL/lymphoma 11Aa (bcl11aa), 2810047E18Rik, BCL-11A, bcl11a, BCL11A-L, BCL11a-M, BCL11A-S, BCL11A-XL, Ctip1, CTIP1, D930021L15Rik, Evi9, EVI9, Evi9a, Evi9b, Evi9c, HBFQTL5, mKIAA1809, wu:fi09f10, zgc:136898, ZNF856Protein level used designations for BCL11A
- B-cell CLL/lymphoma 11A (zinc finger protein)
- B-cell lymphoma/leukemia 11A
- COUP-TF interacting protein 1
- COUP-TF-interacting protein 1
- EVI-9
- ecotropic viral integration site 9 protein
- myeloid leukemia
- B-cell CLL/lymphoma 11A (zinc finger protein) isoform 2
- BCL-11A
- BCL11A B-cell CLL/lymphoma 11A (zinc finger protein) isoform 1
- C2H2-type zinc finger protein
- ecotropic viral integration site 9 homolog
- ecotropic viral integration site 9 protein homolog
- zinc finger protein 856
- B-cell CLL/lymphoma 11A
- bcl11a.1
- fi09f10
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