BIM Produits
(BCL2-Like 11 (Apoptosis Facilitator) (BCL2L11))
Catégories
The protein encoded by this gene belongs to the BCL-2 protein family. BCL-2 family members form hetero- or homodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. The protein encoded by this gene contains a Bcl-2 homology domain 3 (BH3). It has been shown to interact with other members of the BCL-2 protein family, including BCL2, BCL2L1/BCL-X(L), and MCL1, and to act as an apoptotic activator. The expression of this gene can be induced by nerve growth factor (NGF), as well as by the forkhead transcription factor FKHR-L1, which suggests a role of this gene in neuronal and lymphocyte apoptosis. Transgenic studies of the mouse counterpart suggested that this gene functions as an essential initiator of apoptosis in thymocyte-negative selection. Several alternatively spliced transcript variants of this gene have been identified. [provided by RefSeq, Jul 2008].
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Catégories BIM en vedette
BIM Anticorps
High quality antibodies with extensive validation data.
BIM Kits ELISA
Reliable ELISA kits for a wide range of species.
BIM Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BIM recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (8)
N° du produit
ABIN7430234
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p), FACS
Validations
- (4)
N° du produit
ABIN652493
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
IHC, ELISA, IF
Validations
- (3)
N° du produit
ABIN7145302
Quantité
100 μg
Fiche technique
Fiche technique
BIM recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965138
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954063
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1380955
Quantité
96 tests
Fiche technique
Fiche technique
BIM recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346560
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346562
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346558
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BIM
: "Functional disparities among BCL-2 members in tonsillar and leukemic B-cell subsets assessed by BH3-mimetic profiling." dans: Cell death and differentiation, Vol. 24, Issue 1, pp. 111-119, (2018) (PubMed).: "Role of Sirtuin3 in high glucose-induced apoptosis in renal tubular epithelial cells." dans: Biochemical and biophysical research communications, Vol. 480, Issue 3, pp. 387-393, (2017) (PubMed).
: "RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy." dans: Autophagy, Vol. 11, Issue 7, pp. 975-94, (2015) (PubMed).
: "Apoptosis induced by Ginkgo biloba (EGb761) in melanoma cells is Mcl-1-dependent." dans: PLoS ONE, Vol. 10, Issue 4, pp. e0124812, (2015) (PubMed).
: "B cell lymphoma-2 (BCL-2) homology domain 3 (BH3) mimetics demonstrate differential activities dependent upon the functional repertoire of pro- and anti-apoptotic BCL-2 family proteins." dans: The Journal of biological chemistry, Vol. 289, Issue 38, pp. 26481-91, (2014) (PubMed).
: "Valproic acid protects motor neuron death by inhibiting oxidative stress and endoplasmic reticulum stress-mediated cytochrome C release after spinal cord injury." dans: Journal of neurotrauma, Vol. 31, Issue 6, pp. 582-94, (2014) (PubMed).
: "Bim, a proapoptotic protein, up-regulated via transcription factor E2F1-dependent mechanism, functions as a prosurvival molecule in cancer." dans: The Journal of biological chemistry, Vol. 288, Issue 1, pp. 368-81, (2013) (PubMed).
: "OBATOCLAX and ABT-737 induce ER stress responses in human melanoma cells that limit induction of apoptosis." dans: PLoS ONE, Vol. 8, Issue 12, pp. e84073, (2013) (PubMed).
: "Suppression of PP2A is critical for protection of melanoma cells upon endoplasmic reticulum stress." dans: Cell death & disease, Vol. 3, pp. e337, (2012) (PubMed).
: "Loss of the Birt-Hogg-Dubé tumor suppressor results in apoptotic resistance due to aberrant TGFβ-mediated transcription." dans: Oncogene, Vol. 30, Issue 22, pp. 2534-46, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à BIM
BCL2-like 11 (bcl2l11), BCL2 like 11 (BCL2L11), BCL2-like 11 (apoptosis facilitator) (Bcl2l11), BCL2 like 11 (Bcl2l11), 1500006F24Rik, BAM, bim, BIM, Bim, BIMEL, BimL, BOD, BodProtein level used designations for BIM
- BCL2-like 11
- Bcl-2 interacting mediator of cell death
- bcl-2 interacting mediator of cell death
- bcl-2 interacting protein Bim
- bcl-2-like protein 11
- bcl-2-related ovarian death agonist
- Bcl2 interacting mediator of cell death
- bcl2-L-11
- bcl2-interacting mediator of cell death
- Bcl-2 related apoptotic gene product BimL
- bcl-2-related ovarian death protein
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