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BRAF Produits

(B-Raf proto-oncogene, serine/threonine kinase (BRAF))
This gene encodes a protein belonging to the raf/mil family of serine/threonine protein kinases. This protein plays a role in regulating the MAP kinase/ERKs signaling pathway, which affects cell division, differentiation, and secretion. Mutations in this gene are associated with cardiofaciocutaneous syndrome, a disease characterized by heart defects, mental retardation and a distinctive facial appearance. Mutations in this gene have also been associated with various cancers, including non-Hodgkin lymphoma, colorectal cancer, malignant melanoma, thyroid carcinoma, non-small cell lung carcinoma, and adenocarcinoma of lung. A pseudogene, which is located on chromosome X, has been identified for this gene. [provided by RefSeq, Jul 2008].

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Catégories BRAF en vedette

BRAF Anticorps

High quality antibodies with extensive validation data.

BRAF Kits ELISA

Reliable ELISA kits for a wide range of species.

BRAF Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

BRAF recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Monkey
Application WB, IHC, IF, IHC (p), FACS
Validations
  • (9)
N° du produit ABIN1496951
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Dog, Human, Monkey, Rat
Application WB, IHC, IF, IHC (p)
Validations
  • (8)
N° du produit ABIN1496954
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Dog, Human
Application WB, IHC, IHC (p)
Validations
  • (18)
N° du produit ABIN1496961
Quantité 100 μL
Fiche technique Fiche technique

BRAF recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6962346
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6954037
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN5652152
Quantité 96 tests
Fiche technique Fiche technique

BRAF recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
  • (2)
N° du produit ABIN2715104
Quantité 20 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7121967
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1346843
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits BRAF

Rushton, Korb, Kummer, Reichart, Fuchs-Baumgartinger, Tichy, Nell: "Protein expression of KIT, BRAF, GNA11, GNAQ and RASSF1 in feline diffuse iris melanomas." dans: Veterinary journal (London, England : 1997), Vol. 249, pp. 33-40, (2019) (PubMed).

Arnoux, Fina, Lambert, Balandraud, Martin, Ouafik, Kanaan, Roudier, Auger: "Newly Identified BRAF Mutation in Rheumatoid Arthritis." dans: Arthritis & rheumatology (Hoboken, N.J.), Vol. 68, Issue 6, pp. 1377-83, (2016) (PubMed).

Wiggans, Reilly, Kass, Maggs: "Histologic and immunohistochemical predictors of clinical behavior for feline diffuse iris melanoma." dans: Veterinary ophthalmology, Vol. 19 Suppl 1, pp. 44-55, (2016) (PubMed).

Wiersma, de Bruyn, Wei, van Ginkel, Hirashima, Niki, Nishi, Zhou, Pouwels, Samplonius, Nijman, Eggleton, Helfrich, Bremer: "The epithelial polarity regulator LGALS9/galectin-9 induces fatal frustrated autophagy in KRAS mutant colon carcinoma that depends on elevated basal autophagic flux." dans: Autophagy, Vol. 11, Issue 8, pp. 1373-88, (2015) (PubMed).

Chang, Nam, Kook, Kim, Liu, Yao, Jung, Lemos, Seo, Park, Gim, Hong, Huh, Kim, Tan, Liu, Powis, Park, Liang, Kim: "HNF4? is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer." dans: Gut, (2014) (PubMed).

Liu, Chen, Chau, Jan, Chen, Hsu, Lin, Juang, Lu, Cheng, Chen, Chang, Ting, Kao, Hsiao, Huang: "Analysis of protein-protein interactions in cross-talk pathways reveals CRKL protein as a novel prognostic marker in hepatocellular carcinoma." dans: Molecular & cellular proteomics : MCP, Vol. 12, Issue 5, pp. 1335-49, (2013) (PubMed).

Khatamianfar, Valiyeva, Rennie, Lu, Yang, Bauman, Moussa, Xuan: "TRIM59, a novel multiple cancer biomarker for immunohistochemical detection of tumorigenesis." dans: BMJ open, Vol. 2, Issue 5, (2012) (PubMed).

Weisbart, Chan, Heinze, Mory, Nishimura, Colburn: "BRAF drives synovial fibroblast transformation in rheumatoid arthritis." dans: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34299-303, (2010) (PubMed).

Duan, Cobb: "Calcineurin increases glucose activation of ERK1/2 by reversing negative feedback." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 51, pp. 22314-9, (2010) (PubMed).

Di Nicolantonio, Martini, Molinari, Sartore-Bianchi, Arena, Saletti, De Dosso, Mazzucchelli, Frattini, Siena, Bardelli: "Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer." dans: Journal of clinical oncology : official journal of the American Society of Clinical Oncology, Vol. 26, Issue 35, pp. 5705-12, (2008) (PubMed).

Synonymes et noms alternatifs relatifs à BRAF

B-Raf proto-oncogene, serine/threonine kinase (BRAF), B-Raf proto-oncogene, serine/threonine kinase (Braf), B-Raf proto-oncogene, serine/threonine kinase S homeolog (braf.S), B-Raf proto-oncogene, serine/threonine kinase (braf), Braf transforming gene (Braf), si:dkey-222f8.3 (si:dkey-222f8.3), 9930012E13Rik, AA120551, AA387315, AA473386, B-Raf, B-raf, B-RAF1, b-raf1, BRAF, braf, Braf-2, BRAF1, braf1, Braf2, C-RMIL, C87398, C230098H17, D6Ertd631e, fc48g01, NS7, RAFB1, rafb1, RMIL, sierrabraf, wu:fc48g01

Protein level used designations for BRAF

  • 94 kDa B-raf protein
  • B-Raf proto-oncogene serine/threonine-protein kinase (p94)
  • murine sarcoma viral (v-raf) oncogene homolog B1
  • proto-oncogene B-Raf
  • serine/threonine-protein kinase B-raf
  • v-raf murine sarcoma viral oncogene homolog B1
  • B-Raf
  • B-Raf proto-oncogene serine/threonine-protein kinase
  • proto-oncogene c-Rmil
  • rmil serine/threonine-protein kinase
  • serine/threonine kinase
  • serine/threonine-protein kinase Rmil
  • serine/threonine protein kinase BRAF
  • serine/threonine-protein kinase B-raf-like
  • B-raf protein
  • uncharacterized protein LOC561722
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