BRCC3 Produits
(BRCA1/BRCA2-Containing Complex, Subunit 3 (BRCC3))
Catégories
This gene encodes a subunit of the BRCA1-BRCA2-containing complex (BRCC), which is an E3 ubiquitin ligase. This complex plays a role in the DNA damage response, where it is responsible for the stable accumulation of BRCA1 at DNA break sites. The component encoded by this gene can specifically cleave Lys 63-linked polyubiquitin chains, and it regulates the abundance of these polyubiquitin chains in chromatin. The loss of this gene results in abnormal angiogenesis and is associated with syndromic moyamoya, a cerebrovascular angiopathy. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 5. [provided by RefSeq, Jun 2011].
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Catégories BRCC3 en vedette
BRCC3 Anticorps
High quality antibodies with extensive validation data.
BRCC3 Kits ELISA
Reliable ELISA kits for a wide range of species.
BRCC3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
BRCC3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (4)
N° du produit
ABIN7158679
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (3)
N° du produit
ABIN7158678
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IHC (p)
Validations
- (3)
N° du produit
ABIN462274
Quantité
50 μL
Fiche technique
Fiche technique
BRCC3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6954187
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN2945768
Quantité
96 tests
Fiche technique
Fiche technique
BRCC3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1346851
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7414093
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN5709149
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits BRCC3
: "SHMT2 and the BRCC36/BRISC deubiquitinase regulate HIV-1 Tat K63-ubiquitylation and destruction by autophagy." dans: PLoS pathogens, Vol. 14, Issue 5, pp. e1007071, (2018) (PubMed).: "miR-3940-5p associated with genetic damage in workers exposed to hexavalent chromium." dans: Toxicology letters, Vol. 229, Issue 1, pp. 319-26, (2014) (PubMed).
: "BRCC36 is essential for ionizing radiation-induced BRCA1 phosphorylation and nuclear foci formation." dans: Cancer research, Vol. 66, Issue 10, pp. 5039-46, (2006) (PubMed).
: "Regulation of BRCC, a holoenzyme complex containing BRCA1 and BRCA2, by a signalosome-like subunit and its role in DNA repair." dans: Molecular cell, Vol. 12, Issue 5, pp. 1087-99, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à BRCC3
BRCA1/BRCA2-containing complex subunit 3 (BRCC3), DEP domain containing 1B (depdc1b), BRCA1/BRCA2-containing complex subunit 3 (brcc3), BRCA1/BRCA2-containing complex, subunit 3 (Brcc3), BRCA1/BRCA2-containing complex subunit 3 L homeolog (brcc3.L), BRCC3, brcc3, BRCC36, brcc36, C6.1A, CXorf53, xtp1Protein level used designations for BRCC3
- BRCA1/BRCA2-containing complex, subunit 3
- c6.1A
- BRCA1-A complex subunit BRCC36
- BRCA1/BRCA2-containing complex subunit 3
- BRCA1/BRCA2-containing complex subunit 36
- BRISC complex subunit BRCC36
- lys-63-specific deubiquitinase BRCC36
- 6.1A protein
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