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BRD4 Produits

(Bromodomain Containing 4 (BRD4))

Catégories

The protein encoded by this gene is homologous to the murine protein MCAP, which associates with chromosomes during mitosis, and to the human RING3 protein, a serine/threonine kinase. Each of these proteins contains two bromodomains, a conserved sequence motif which may be involved in chromatin targeting. This gene has been implicated as the chromosome 19 target of translocation t(15\;19)(q13\;p13.1), which defines an upper respiratory tract carcinoma in young people. Two alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2008].

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Catégories BRD4 en vedette

BRD4 Anticorps

High quality antibodies with extensive validation data.

BRD4 Kits ELISA

Reliable ELISA kits for a wide range of species.

BRD4 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

BRD4 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application IHC, IF
Validations
  • (4)
N° du produit ABIN7010051
Quantité 60 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (4)
N° du produit ABIN6137653
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
N° du produit ABIN6260309
Quantité 100 μL
Fiche technique Fiche technique

BRD4 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965241
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6954198
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1124204
Quantité 96 tests
Fiche technique Fiche technique

BRD4 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7122050
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7319875
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (1)
N° du produit ABIN6964231
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits BRD4

Yamada, Honma, Mochizuki, Goda: "BRD4 regulates fructose-inducible lipid accumulation-related genes in the mouse liver." dans: Metabolism: clinical and experimental, Vol. 65, Issue 10, pp. 1478-88, (2017) (PubMed).

Surface, Fields, Subramanian, Behmer, Udeshi, Peach, Carr, Jaffe, Boyer: "H2A.Z.1 Monoubiquitylation Antagonizes BRD2 to Maintain Poised Chromatin in ESCs." dans: Cell reports, Vol. 14, Issue 5, pp. 1142-55, (2016) (PubMed).

Zimmermann, Aguilera, Castellucci, Rossato, Costa, Lunardi, Ostuni, Girolomoni, Natoli, Bazzoni, Tamassia, Cassatella: "Chromatin remodelling and autocrine TNFα are required for optimal interleukin-6 expression in activated human neutrophils." dans: Nature communications, Vol. 6, pp. 6061, (2015) (PubMed).

Alekseyenko, Walsh, Wang, Grayson, Hsi, Kharchenko, Kuroda, French: "The oncogenic BRD4-NUT chromatin regulator drives aberrant transcription within large topological domains." dans: Genes & development, Vol. 29, Issue 14, pp. 1507-23, (2015) (PubMed).

Flajollet, Rachez, Ploton, Schulz, Gallais, Métivier, Pawlak, Leray, Issulahi, Héliot, Staels, Salbert, Lefebvre: "The elongation complex components BRD4 and MLLT3/AF9 are transcriptional coactivators of nuclear retinoid receptors." dans: PLoS ONE, Vol. 8, Issue 6, pp. e64880, (2013) (PubMed).

Rahman, Sowa, Ottinger, Smith, Shi, Harper, Howley: "The Brd4 extraterminal domain confers transcription activation independent of pTEFb by recruiting multiple proteins, including NSD3." dans: Molecular and cellular biology, Vol. 31, Issue 13, pp. 2641-52, (2011) (PubMed).

Zuber, Shi, Wang, Rappaport, Herrmann, Sison, Magoon, Qi, Blatt, Wunderlich, Taylor, Johns, Chicas, Mulloy, Kogan, Brown, Valent, Bradner, Lowe, Vakoc: "RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia." dans: Nature, Vol. 478, Issue 7370, pp. 524-8, (2011) (PubMed).

Mertz, Conery, Bryant, Sandy, Balasubramanian, Mele, Bergeron, Sims: "Targeting MYC dependence in cancer by inhibiting BET bromodomains." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 108, Issue 40, pp. 16669-74, (2011) (PubMed).

Powell, Smith, Sowa, Harper, Iftner, Stubenrauch, Howley: "NCoR1 mediates papillomavirus E8;E2C transcriptional repression." dans: Journal of virology, Vol. 84, Issue 9, pp. 4451-60, (2010) (PubMed).

Gagnon, Joubert, Sénéchal, Fradet-Turcotte, Torre, Archambault: "Proteasomal degradation of the papillomavirus E2 protein is inhibited by overexpression of bromodomain-containing protein 4." dans: Journal of virology, Vol. 83, Issue 9, pp. 4127-39, (2009) (PubMed).

Synonymes et noms alternatifs relatifs à BRD4

bromodomain containing 4 L homeolog (brd4.L), bromodomain containing 4 (BRD4), bromodomain containing 4 (brd4), bromodomain-containing protein 4 (LOC100409351), bromodomain containing 4 (Brd4), BRD4, brd4-b, Brd5, CAP, fb18g03, HUNK1, HUNKI, MCAP, WI-11513, wu:fb18g03

Protein level used designations for BRD4

  • Bromodomain-containing protein 4B
  • bromodomain-containing protein 4B
  • bromodomain containing 4
  • bromodomain-containing protein 4
  • bromodomain 4
  • bromodomain-containing protein 4-like
  • bromodomain containing protein 4
  • bromodomain-containing 4
  • chromosome-associated protein
  • bromodomain-containing 5
  • fsh-like protein
  • mitotic chromosome-associated protein
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