BTBD12 Produits
(BTB (POZ) Domain Containing 12 (BTBD12))
Catégories
This gene encodes a structure-specific endonuclease subunit. The encoded protein contains a central BTB domain and it forms a multiprotein complex with the ERCC4(XPF)-ERCC1, MUS81-EME1, and SLX1 endonucleases, and also associates with MSH2/MSH3 mismatch repair complex, telomere binding complex TERF2(TRF2)-TERF2IP(RAP1), the protein kinase PLK1 and the uncharacterized protein C20orf94. The multiprotein complex is required for repair of specific types of DNA lesions and is critical for cellular responses to replication fork failure. The encoded protein acts as a docking platform for the assembly of multiple structure-specific endonucleases.[provided by RefSeq, Jan 2011].
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Catégories BTBD12 en vedette
BTBD12 Anticorps
High quality antibodies with extensive validation data.
BTBD12 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB
Validations
- (1)
- (1)
N° du produit
ABIN529697
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human, Monkey
Application
WB
Validations
- (1)
N° du produit
ABIN6746693
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
IP, IHC (p), IHC, IF
Validations
- (1)
N° du produit
ABIN2571811
Quantité
50 μL
Fiche technique
Fiche technique
BTBD12 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Schizosaccharomyces pombe
Source
Yeast
Validations
N° du produit
ABIN1652594
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits BTBD12
: "Expression of Telomere-Associated Proteins is Interdependent to Stabilize Native Telomere Structure and Telomere Dysfunction by G-Quadruplex Ligand Causes TERRA Upregulation." dans: Cell biochemistry and biophysics, (2017) (PubMed).: "Activation of the DNA Damage Response Is a Conserved Function of HIV-1 and HIV-2 Vpr That Is Independent of SLX4 Recruitment." dans: mBio, Vol. 7, Issue 5, (2016) (PubMed).
: "SLX4 assembles a telomere maintenance toolkit by bridging multiple endonucleases with telomeres." dans: Cell reports, Vol. 4, Issue 5, pp. 861-9, (2013) (PubMed).
: "The nuclease hSNM1B/Apollo is linked to the Fanconi anemia pathway via its interaction with FANCP/SLX4." dans: Human molecular genetics, Vol. 21, Issue 22, pp. 4948-56, (2012) (PubMed).
: "Mammalian BTBD12 (SLX4) protects against genomic instability during mammalian spermatogenesis." dans: PLoS genetics, Vol. 7, Issue 6, pp. e1002094, (2011) (PubMed).
: "Mutations of the SLX4 gene in Fanconi anemia." dans: Nature genetics, Vol. 43, Issue 2, pp. 142-6, (2011) (PubMed).
Synonymes et noms alternatifs relatifs à BTBD12
SLX4 structure-specific endonuclease subunit (Slx4), SLX4 structure-specific endonuclease subunit (SLX4), SLX4 structure-specific endonuclease subunit homolog (SLX4), SLX4 structure-specific endonuclease subunit homolog (S. cerevisiae) (Slx4), AI256635, AI426760, Btbd12, BTBD12, D16Bwg1016e, FANCP, MUS312, RGD1566009Protein level used designations for BTBD12
- BTB (POZ) domain containing 12
- SLX4 structure-specific endonuclease subunit homolog
- structure-specific endonuclease subunit SLX4
- BTB/POZ domain-containing protein 12
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