The butyrophilin (BTN) genes are a group of major histocompatibility complex (MHC)-associated genes that encode type I membrane proteins with 2 extracellular immunoglobulin (Ig) domains and an intracellular B30.2 (PRYSPRY) domain. Three subfamilies of human BTN genes are located in the MHC class I region: the single-copy BTN1A1 gene (MIM 601610) and the BTN2 (e.g., BTN2A1\; MIM 613590) and BTN3 (e.g., BNT3A3) genes, which have undergone tandem duplication, resulting in 3 copies of each (summary by Smith et al., 2010 [PubMed 20208008]).[supplied by OMIM, Nov 2010].
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Gelman, Chen, Lisinicchia, Soukup, Carmical, Starkey, Masliah, Commins, Brandt, Grant, Singer, Levine, Miller, Winkler, Fox, Luxon, Morgello: "The National NeuroAIDS Tissue Consortium brain gene array: two types of HIV-associated neurocognitive impairment." dans: PLoS ONE, Vol. 7, Issue 9, pp. e46178, (2012) (PubMed).
Synonymes et noms alternatifs relatifs à BTN3A3
butyrophilin-like 4 (Btnl4), butyrophilin subfamily 3 member A3 (BTN3A3), butyrophilin, subfamily 3, member A3 (BTN3A3), BTF3, Btn3a3, EG632126, NG11