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CASP5 Produits

(Caspase 5, Apoptosis-Related Cysteine Peptidase (CASP5))
This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. Overexpression of the active form of this enzyme induces apoptosis in fibroblasts. Max, a central component of the Myc\\/Max\\/Mad transcription regulation network important for cell growth, differentiation, and apoptosis, is cleaved by this protein\\\\; this process requires Fas-mediated dephosphorylation of Max. The expression of this gene is regulated by interferon-gamma and lipopolysaccharide. Alternatively spliced transcript variants have been identified for this gene. [provided by RefSeq, Aug 2010].

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Catégories CASP5 en vedette

CASP5 Anticorps

High quality antibodies with extensive validation data.

CASP5 Kits ELISA

Reliable ELISA kits for a wide range of species.

CASP5 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

CASP5 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IHC, ICC, IP
Validations
  • (4)
N° du produit ABIN7432568
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, FACS, IHC (p)
Validations
  • (4)
N° du produit ABIN654898
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, FACS
Validations
  • (5)
N° du produit ABIN3030309
Quantité 0.4 mL
Fiche technique Fiche technique

CASP5 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965469
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6954421
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN5652656
Quantité 96 tests
Fiche technique Fiche technique

CASP5 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1348109
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7391987
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN5709203
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits CASP5

Göös, Fogarty, Sahu, Plagnol, Rajamäki, Nurmi, Liu, Einarsdottir, Jouppila, Pettersson, Vihinen, Krjutskov, Saavalainen, Järvinen, Muurinen, Greco, Scala, Curtis, Nordström, Flaumenhaft, Vaarala et al.: "Gain-of-function CEBPE mutation causes noncanonical autoinflammatory inflammasomopathy. ..." dans: The Journal of allergy and clinical immunology, (2019) (PubMed).

Bian, Pelegrino, Henriksson, Pflugfelder, Volpe, Li, de Paiva: "Differential Effects of Dexamethasone and Doxycycline on Inflammation and MMP Production in Murine Alkali-Burned Corneas Associated with Dry Eye." dans: The ocular surface, Vol. 14, Issue 2, pp. 242-54, (2016) (PubMed).

Bian, Pelegrino, Pflugfelder, Volpe, Li, de Paiva: "Desiccating Stress-Induced MMP Production and Activity Worsens Wound Healing in Alkali-Burned Corneas." dans: Investigative ophthalmology & visual science, Vol. 56, Issue 8, pp. 4908-18, (2015) (PubMed).

Knodler, Crowley, Sham, Yang, Wrande, Ma, Ernst, Steele-Mortimer, Celli, Vallance: "Noncanonical inflammasome activation of caspase-4/caspase-11 mediates epithelial defenses against enteric bacterial pathogens." dans: Cell host & microbe, Vol. 16, Issue 2, pp. 249-56, (2014) (PubMed).

Bian, Elner, Khanna, Murga-Zamalloa, Patil, Elner: "Expression and functional roles of caspase-5 in inflammatory responses of human retinal pigment epithelial cells." dans: Investigative ophthalmology & visual science, Vol. 52, Issue 12, pp. 8646-56, (2011) (PubMed).

Murakami, Tolstykh, Bao, Niu, Steuer, Bao, Chang, Espiritu, Bansal, Lam, Otto, Sofia, Furman: "Mechanism of activation of PSI-7851 and its diastereoisomer PSI-7977." dans: The Journal of biological chemistry, Vol. 285, Issue 45, pp. 34337-47, (2010) (PubMed).

Chen, Xia, Fang, Hawke, Lu: "Caspase-10-mediated heat shock protein 90 beta cleavage promotes UVB irradiation-induced cell apoptosis." dans: Molecular and cellular biology, Vol. 29, Issue 13, pp. 3657-64, (2009) (PubMed).

Hasegawa, Yamada, Komiyama, Hayashi, Ishibashi, Sunazuka, Izuhara, Sugahara, Tsuruda, Masuda, Takasu, Tsukasaki, Tomonaga, Kamihira et al.: "A novel natural compound, a cycloanthranilylproline derivative (Fuligocandin B), sensitizes leukemia cells to apoptosis induced by tumor necrosis factor related apoptosis-inducing ligand (TRAIL) ..." dans: Blood, Vol. 110, Issue 5, pp. 1664-74, (2007) (PubMed).

Martinon, Tschopp: "Inflammatory caspases: linking an intracellular innate immune system to autoinflammatory diseases." dans: Cell, Vol. 117, Issue 5, pp. 561-74, (2004) (PubMed).

Gracie, Robertson, McInnes: "Interleukin-18." dans: Journal of leukocyte biology, Vol. 73, Issue 2, pp. 213-24, (2003) (PubMed).

Synonymes et noms alternatifs relatifs à CASP5

caspase 5 (CASP5), caspase-5 (LOC100437308), CASP5, ICE(rel)III, ICEREL-III, ICH-3

Protein level used designations for CASP5

  • CASP-5
  • ICE(rel)-III
  • TY protease
  • caspase 5, apoptosis-related cysteine protease
  • caspase-5
  • protease ICH-3
  • protease TY
  • caspase 5
  • caspase 5, apoptosis-related cysteine peptidase
  • caspase-5-like
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