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C-Type Lectin Domain Family 4, Member M Anticorps

(C-Type Lectin Domain Family 4, Member M (CLEC4M))

This gene encodes a transmembrane receptor and is often referred to as L-SIGN because of its expression in the endothelial cells of the lymph nodes and liver. The encoded protein is involved in the innate immune system and recognizes numerous evolutionarily divergent pathogens ranging from parasites to viruses, with a large impact on public health. The protein is organized into three distinct domains: an N-terminal transmembrane domain, a tandem-repeat neck domain and C-type lectin carbohydrate recognition domain. The extracellular region consisting of the C-type lectin and neck domains has a dual function as a pathogen recognition receptor and a cell adhesion receptor by binding carbohydrate ligands on the surface of microbes and endogenous cells. The neck region is important for homo-oligomerization which allows the receptor to bind multivalent ligands with high avidity. Variations in the number of 23 amino acid repeats in the neck domain of this protein are common and have a significant impact on ligand binding ability. This gene is closely related in terms of both sequence and function to a neighboring gene (GeneID 30835\; often referred to as DC-SIGN or CD209). DC-SIGN and L-SIGN differ in their ligand-binding properties and distribution. Alternative splicing results in multiple variants.[provided by RefSeq, Feb 2009].

Recommandation

C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) anticorps (ABIN7441907)

CLEC4M Reactivité: Humain WB, IHC, IP, ICC Hôte: Lapin Polyclonal unconjugated

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Recommandation

C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) anticorps (ABIN7193339)

CLEC4M Reactivité: Humain WB, ELISA, FACS Hôte: Souris Monoclonal 8A1B3 unconjugated

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Recommandation

C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) anticorps (ABIN7189476)

CLEC4M Reactivité: Humain WB, ELISA, IHC Hôte: Lapin Polyclonal unconjugated

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C-Type Lectin Domain Family 4, Member M Anticorps par Réactivité

Trouvez C-Type Lectin Domain Family 4, Member M Anticorps pour une variété d'espèces telles que anti-Human C-Type Lectin Domain Family 4, Member M, anti-Mouse C-Type Lectin Domain Family 4, Member M, anti-Rat C-Type Lectin Domain Family 4, Member M. Les espèces listées ci-dessous sont parmi celles disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

C-Type Lectin Domain Family 4, Member M Anticorps par Application

Trouver C-Type Lectin Domain Family 4, Member M Anticorps validé pour une application spécifique telle que WB, ELISA, IHC, FACS. Certaines des applications disponibles sont énumérées ci-dessous. Cliquez sur un lien pour accéder aux produits correspondants

C-Type Lectin Domain Family 4, Member M Anticorps par Hote

On trouve ici des C-Type Lectin Domain Family 4, Member M Anticorps avec un Hote spécifique. Les Hote mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

C-Type Lectin Domain Family 4, Member M Anticorps par Epitope

Trouver C-Type Lectin Domain Family 4, Member M Anticorps avec un épitope spécifique. Les épitopes listés ci-dessous sont parmi ceux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

C-Type Lectin Domain Family 4, Member M Anticorps par Clonalité

Trouvez les C-Type Lectin Domain Family 4, Member M Anticorps monoclonaux ou polyclonaux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

C-Type Lectin Domain Family 4, Member M Anticorps par Clone

On trouve ici des C-Type Lectin Domain Family 4, Member M Anticorps avec un Clone spécifique. Les Clone mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits

C-Type Lectin Domain Family 4, Member M Anticorps par Conjugué

Trouvez C-Type Lectin Domain Family 4, Member M Anticorps avec un conjugué spécifique tel que Biotin, FITC, Alexa Fluor 488. Les conjugués listés ci-dessous sont parmi ceux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.

C-Type Lectin Domain Family 4, Member M Anticorps fréquemment utilisés

Produit

Reactivity

Application

Validations

N° du produit

Quantité

Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 242-399) anticorps

Reactivity Human

Application WB, IHC, IP, ICC

Validations

N° du produit ABIN7441907

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 237-399) anticorps

Reactivity Human

Application WB, ELISA, FACS

Validations

N° du produit ABIN7193339

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 271-320) anticorps

Reactivity Human

Application WB, ELISA, IHC

Validations

N° du produit ABIN7189476

Quantité 100 μg

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 238-382) anticorps

Reactivity Human

Application WB, ELISA, IF

Validations

N° du produit ABIN7146089

Quantité 100 μg

Fiche technique Fiche technique

Recombinant anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) anticorps

Reactivity Human

Application IHC, FACS

Validations

N° du produit ABIN5668174

Quantité 200 μg

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) anticorps

Reactivity Human

Application WB, ELISA

Validations

N° du produit ABIN564490

Quantité 100 μg

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 51-100) anticorps

Reactivity Human, Monkey

Application WB, IHC, IHC (p)

Validations

N° du produit ABIN203419

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (N-Term) anticorps

Reactivity Human

Application WB, IHC

Validations

N° du produit ABIN630277

Quantité 100 μg

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 285-394) anticorps

Reactivity Human

Application WB, ELISA

Validations

N° du produit ABIN564489

Quantité 50 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 280-399) anticorps

Reactivity Human

Application WB

Validations

N° du produit ABIN7265983

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 143-192) anticorps

Reactivity Human

Application WB

Validations

N° du produit ABIN6745594

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (N-Term) anticorps

Reactivity Human

Application WB

Validations

N° du produit ABIN6740764

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (AA 323-372) anticorps

Reactivity Human, Monkey

Application WB, IHC, IHC (p)

Validations

N° du produit ABIN6755289

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (N-Term) anticorps

Reactivity Human, Pig

Application WB, IHC

Validations

N° du produit ABIN2775393

Quantité 100 μL

Fiche technique Fiche technique

anti-C-Type Lectin Domain Family 4, Member M (CLEC4M) (Middle Region) anticorps

Reactivity Human, Mouse, Pig, Rabbit, Rat, Zebrafish (Danio rerio)

Application WB

Validations

N° du produit ABIN2775394

Quantité 100 μL

Fiche technique Fiche technique

Dernières publications pour nos C-Type Lectin Domain Family 4, Member M Anticorps

Swystun, Lai, Notley, Georgescu, Paine, Mewburn, Nesbitt, Schledzewski, Géraud, Kzhyshkowska, Goerdt, Hopman, Montgomery, James, Lillicrap: "The endothelial cell receptor stabilin-2 regulates VWF-FVIII complex half-life and immunogenicity." dans: The Journal of clinical investigation, Vol. 128, Issue 9, pp. 4057-4073, (2018) (PubMed).

Botting, Bertram, Baharlou, Sandgren, Fletcher, Rhodes, Rana, Plasto, Wang, Lim, Barnouti, Kohout, Papadopoulos, Merten, Olbourne, Cunningham, Haniffa, Harman: "Phenotypic and functional consequences of different isolation protocols on skin mononuclear phagocytes." dans: Journal of leukocyte biology, Vol. 101, Issue 6, pp. 1393-1403, (2017) (PubMed).

Mukherjee, Dowd, Manhart, Ledgerwood, Durbin, Whitehead, Pierson: "Mechanism and significance of cell type-dependent neutralization of flaviviruses." dans: Journal of virology, Vol. 88, Issue 13, pp. 7210-20, (2014) (PubMed).

Rydz, Swystun, Notley, Paterson, Riches, Sponagle, Boonyawat, Montgomery, James, Lillicrap: "The C-type lectin receptor CLEC4M binds, internalizes, and clears von Willebrand factor and contributes to the variation in plasma von Willebrand factor levels." dans: Blood, Vol. 121, Issue 26, pp. 5228-37, (2013) (PubMed).

Johnson, McLellan, Graham: "Respiratory syncytial virus glycoprotein G interacts with DC-SIGN and L-SIGN to activate ERK1 and ERK2." dans: Journal of virology, Vol. 86, Issue 3, pp. 1339-47, (2012) (PubMed).

Jain, Manuel, Khan, Ahuja, Quann, Wigdahl: "DC-SIGN mediates cell-free infection and transmission of human T-cell lymphotropic virus type 1 by dendritic cells." dans: Journal of virology, Vol. 83, Issue 21, pp. 10908-21, (2009) (PubMed).

Crosby, Lalor, Ross, Newsome, Adams: "Adhesion of human haematopoietic (CD34+) stem cells to human liver compartments is integrin and CD44 dependent and modulated by CXCR3 and CXCR4." dans: Journal of hepatology, Vol. 51, Issue 4, pp. 734-49, (2009) (PubMed).

Karrar, Broomé, Uzunel, Qureshi, Sumitran-Holgersson: "Human liver sinusoidal endothelial cells induce apoptosis in activated T cells: a role in tolerance induction." dans: Gut, Vol. 56, Issue 2, pp. 243-52, (2007) (PubMed).

Lai, Sun, Zhang, Jennings, Lalor, Hubscher, McKeating, Adams: "Expression of DC-SIGN and DC-SIGNR on human sinusoidal endothelium: a role for capturing hepatitis C virus particles." dans: The American journal of pathology, Vol. 169, Issue 1, pp. 200-8, (2006) (PubMed).

Chaipan, Soilleux, Simpson, Hofmann, Gramberg, Marzi, Geier, Stewart, Eisemann, Steinkasserer, Suzuki-Inoue, Fuller, Pearce, Watson, Hoxie, Baribaud, Pöhlmann: "DC-SIGN and CLEC-2 mediate human immunodeficiency virus type 1 capture by platelets." dans: Journal of virology, Vol. 80, Issue 18, pp. 8951-60, (2006) (PubMed).

Pseudonymes pour C-Type Lectin Domain Family 4, Member M Anticorps

C-type lectin domain family 4 member M (CLEC4M) Anticorps
CD209B Anticorps
CD209L Anticorps
CD299 Anticorps
DC-SIGN2 Anticorps
DC-SIGNR Anticorps
DCSIGNR Anticorps
HP10347 Anticorps
L-SIGN Anticorps
LSIGN Anticorps

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C-Type Lectin Domain Family 4, Member M Anticorps par Réactivité

C-Type Lectin Domain Family 4, Member M Anticorps par Application

C-Type Lectin Domain Family 4, Member M Anticorps par Hote

C-Type Lectin Domain Family 4, Member M Anticorps par Epitope

C-Type Lectin Domain Family 4, Member M Anticorps par Clonalité

C-Type Lectin Domain Family 4, Member M Anticorps par Clone

C-Type Lectin Domain Family 4, Member M Anticorps par Conjugué

C-Type Lectin Domain Family 4, Member M Anticorps fréquemment utilisés

Dernières publications pour nos C-Type Lectin Domain Family 4, Member M Anticorps

Pseudonymes pour C-Type Lectin Domain Family 4, Member M Anticorps

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