This gene encodes a member of a superfamily of proteins composed predominantly of tandemly arrayed short consensus repeats of approximately 60 amino acids. A single, unique beta-chain encoded by this gene assembles with seven identical alpha-chains into the predominant isoform of C4b-binding protein, a multimeric protein that controls activation of the complement cascade through the classical pathway. C4b-binding protein has a regulatory role in the coagulation system also, mediated through the beta-chain binding of protein S, a vitamin K-dependent protein that serves as a cofactor of activated protein C. The genes encoding both alpha and beta chains are located adjacent to each other on human chromosome 1 in the regulator of complement activation gene cluster. Alternative splicing gives rise to multiple transcript variants. [provided by RefSeq, Jul 2008].
antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.
Domenech, Ramos-Sevillano, García, Moscoso, Yuste: "Biofilm formation avoids complement immunity and phagocytosis of Streptococcus pneumoniae." dans: Infection and immunity, Vol. 81, Issue 7, pp. 2606-15, (2013) (PubMed).
Blom, Villoutreix, Dahlbäck: "Functions of human complement inhibitor C4b-binding protein in relation to its structure." dans: Archivum immunologiae et therapiae experimentalis, Vol. 52, Issue 2, pp. 83-95, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à C4BP
complement component 4 binding protein (C4bp), complement component 4 binding protein beta (C4BPB), AI195242, C4BP, C4bpa