C5A Produits
(Complement Component 5a (C5a))
Catégories
The protein encoded by this gene is the fifth component of complement, which plays an important role in inflammatory and cell killing processes. This protein is comprised of alpha and beta polypeptide chains that are linked by a disulfide bridge. An activation peptide, C5a, which is an anaphylatoxin that possesses potent spasmogenic and chemotactic activity, is derived from the alpha polypeptide via cleavage with a convertase. The C5b macromolecular cleavage product can form a complex with the C6 complement component, and this complex is the basis for formation of the membrane attack complex, which includes additional complement components. Mutations in this gene cause complement component 5 deficiency, a disease where patients show a propensity for severe recurrent infections. Defects in this gene have also been linked to a susceptibility to liver fibrosis and to rheumatoid arthritis. [provided by RefSeq, Jul 2008].
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Catégories C5A en vedette
C5A Anticorps
High quality antibodies with extensive validation data.
C5A Kits ELISA
Reliable ELISA kits for a wide range of species.
C5A Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
C5A recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (9)
N° du produit
ABIN7442321
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IP, ICC
Validations
- (5)
N° du produit
ABIN7427906
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Mouse, Rat
Application
WB, IHC (p)
Validations
- (6)
N° du produit
ABIN3029692
Quantité
100 μg
Fiche technique
Fiche technique
C5A recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6962855
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (6)
- (1)
N° du produit
ABIN6955014
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (3)
- (1)
N° du produit
ABIN6955015
Quantité
96 tests
Fiche technique
Fiche technique
C5A recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7274012
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122470
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
N° du produit
ABIN2180666
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits C5A
: "C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis." dans: Frontiers in immunology, Vol. 10, pp. 1866, (2020) (PubMed).: "C5aR deficiency attenuates the breast cancer development via the p38/p21 axis." dans: Aging, Vol. 12, Issue 14, pp. 14285-14299, (2020) (PubMed).
: "Inhibition of osteoclast activity by complement regulation with DF3016A, a novel small-molecular-weight C5aR inhibitor." dans: Biomedicine & pharmacotherapy, Vol. 123, pp. 109764, (2020) (PubMed).
: "Complement C5a/C5aR pathway potentiates the pathogenesis of gastric cancer by down-regulating p21 expression." dans: Cancer letters, Vol. 412, pp. 30-36, (2017) (PubMed).
: "Complement Split Products C3a/C5a and Receptors: Are They Regulated by Circulating Angiotensin II Type 1 Receptor Autoantibody in Severe Preeclampsia?" dans: Gynecologic and obstetric investigation, Vol. 81, Issue 1, pp. 28-33, (2016) (PubMed).
: "Consistency and pathophysiological characterization of a rat polymicrobial sepsis model via the improved cecal ligation and puncture surgery." dans: International immunopharmacology, Vol. 32, pp. 66-75, (2016) (PubMed).
: "Acute and prolonged complement activation in the central nervous system during herpes simplex encephalitis." dans: Journal of neuroimmunology, Vol. 295-296, pp. 130-8, (2016) (PubMed).
: "Cadmium-induced immune abnormality is a key pathogenic event in human and rat models of preeclampsia." dans: Environmental pollution (Barking, Essex : 1987), Vol. 218, pp. 770-782, (2016) (PubMed).
: "Nanofibrous heparin and heparin-mimicking multilayers as highly effective endothelialization and antithrombogenic coatings." dans: Biomacromolecules, Vol. 16, Issue 3, pp. 992-1001, (2015) (PubMed).
: "Safety evaluation of intravenously administered mono-thioated aptamer against E-selectin in mice." dans: Toxicology and applied pharmacology, Vol. 287, Issue 1, pp. 86-92, (2015) (PubMed).
Synonymes et noms alternatifs relatifs à C5A
complement C5 (C5), C5a, C5b, CPAMD4, Hc, RGD1561905Protein level used designations for C5A
- C3 and PZP-like alpha-2-macroglobulin domain-containing protein 4
- C5a anaphylatoxin
- anaphylatoxin C5a analog
- complement C5
- prepro-C5
- anaphylatoxin
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