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CBL Produits

(Cas-Br-M (Murine) Ecotropic Retroviral Transforming Sequence (CBL))

Catégories

This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder. [provided by RefSeq, Mar 2012].

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Catégories CBL en vedette

CBL Anticorps

High quality antibodies with extensive validation data.

CBL Kits ELISA

Reliable ELISA kits for a wide range of species.

CBL Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

CBL recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC, ICC, FACS
Validations
  • (3)
  • (7)
N° du produit ABIN968993
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IP
Validations
  • (5)
N° du produit ABIN560198
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB, IP
Validations
  • (4)
N° du produit ABIN949994
Quantité 100 μL
Fiche technique Fiche technique

CBL recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380198
Quantité 2 x 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380199
Quantité 2 x 96 tests
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1380200
Quantité 2 x 96 tests
Fiche technique Fiche technique

CBL recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1348168
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1348170
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7417087
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits CBL

Ye, Cihil, Stolz, Pilewski, Stanton, Swiatecka-Urban: "c-Cbl facilitates endocytosis and lysosomal degradation of cystic fibrosis transmembrane conductance regulator in human airway epithelial cells." dans: The Journal of biological chemistry, Vol. 285, Issue 35, pp. 27008-18, (2010) (PubMed).

Sproul, Xu, Wilhelm, Gire, Greene: "Cbl negatively regulates JNK activation and cell death." dans: Cell research, Vol. 19, Issue 8, pp. 950-61, (2009) (PubMed).

Sanada, Suzuki, Shih, Otsu, Kato, Yamazaki, Tamura, Honda, Sakata-Yanagimoto, Kumano, Oda, Yamagata, Takita, Gotoh, Nakazaki, Kawamata, Onodera, Nobuyoshi, Hayashi, Harada, Kurokawa, Chiba, Mori et al.: "Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. ..." dans: Nature, Vol. 460, Issue 7257, pp. 904-8, (2009) (PubMed).

Loh, Sakai, Flotho, Kang, Fliegauf, Archambeault, Mullighan, Chen, Bergstraesser, Bueso-Ramos, Emanuel, Hasle, Issa, van den Heuvel-Eibrink, Locatelli, Stary, Trebo, Wlodarski, Zecca, Shannon et al.: "Mutations in CBL occur frequently in juvenile myelomonocytic leukemia. ..." dans: Blood, Vol. 114, Issue 9, pp. 1859-63, (2009) (PubMed).

Swaminathan, Tsygankov: "The Cbl family proteins: ring leaders in regulation of cell signaling." dans: Journal of cellular physiology, Vol. 209, Issue 1, pp. 21-43, (2006) (PubMed).

Thien, Langdon: "c-Cbl and Cbl-b ubiquitin ligases: substrate diversity and the negative regulation of signalling responses." dans: The Biochemical journal, Vol. 391, Issue Pt 2, pp. 153-66, (2005) (PubMed).

Jiang, Huang, Marusyk, Sorkin: "Grb2 regulates internalization of EGF receptors through clathrin-coated pits." dans: Molecular biology of the cell, Vol. 14, Issue 3, pp. 858-70, (2003) (PubMed).

Miura-Shimura, Duan, Rao, Reddi, Shimura, Rottapel, Druker, Tsygankov, Band, Band: "Cbl-mediated ubiquitinylation and negative regulation of Vav." dans: The Journal of biological chemistry, Vol. 278, Issue 40, pp. 38495-504, (2003) (PubMed).

Thien, Langdon: "Cbl: many adaptations to regulate protein tyrosine kinases." dans: Nature reviews. Molecular cell biology, Vol. 2, Issue 4, pp. 294-307, (2001) (PubMed).

Tsygankov, Teckchandani, Feshchenko, Swaminathan: "Beyond the RING: CBL proteins as multivalent adapters." dans: Oncogene, Vol. 20, Issue 44, pp. 6382-402, (2001) (PubMed).

Synonymes et noms alternatifs relatifs à CBL

Casitas B-lineage lymphoma (Cbl), Cbl proto-oncogene (CBL), Cbl proto-oncogene (Cbl), 4732447J05Rik, c-Cbl, C-CBL, c-cbl-like, cbl, Cbl-2, CBL2, FRA11B, NSLL, RGD1561386, RNF55

Protein level used designations for CBL

  • E3 ubiquitin-protein ligase CBL
  • casitas B-lineage lymphoma proto-oncogene
  • proto-oncogene c-CBL
  • signal transduction protein CBL
  • Cas-Br-M (murine) ecotropic retroviral transforming sequence
  • RING finger protein 55
  • fragile site, folic acid type, rare, fra(11)(q23.3)
  • oncogene CBL2
  • proto-oncogene c-Cbl
  • Casitas B-lineage lymphoma
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