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Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Produits

(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.

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Catégories Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase en vedette

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Anticorps

High quality antibodies with extensive validation data.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Kits ELISA

Reliable ELISA kits for a wide range of species.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Application WB, FACS, IHC (p)
Validations
  • (3)
N° du produit ABIN652612
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
  • (2)
N° du produit ABIN760256
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse, Rat
Application WB, ELISA, IHC
Validations
  • (2)
N° du produit ABIN6260515
Quantité 100 μL
Fiche technique Fiche technique

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965529
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1131076
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6200984
Quantité 96 tests
Fiche technique Fiche technique

Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1348172
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7122186
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1348174
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase

Desai, Kharade, Parekh, Iyer, Agarwal: "Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b)." dans: The Journal of biological chemistry, Vol. 290, Issue 42, pp. 25595-608, (2015) (PubMed).

Gruber, Hinterleitner, Hermann-Kleiter, Meisel, Kleiter, Wang, Viola, Pfeifhofer-Obermair, Baier: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." dans: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).

Vivanco, Rohle, Versele, Iwanami, Kuga, Oldrini, Tanaka, Dang, Kubek, Palaskas, Hsueh, Evans, Mulholland, Wolle, Rajasekaran, Rajasekaran, Liau, Cloughesy, Dikic, Brennan, Wu, Mischel, Perera et al.: "The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 14, pp. 6459-64, (2010) (PubMed).

Synonymes et noms alternatifs relatifs à Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase

Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S), Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L), Casitas B-lineage lymphoma b (Cblb), Cbl proto-oncogene B (Cblb), Cbl proto-oncogene B (CBLB), AI429560, AI851073, Cbl-b, cblb, rnf56

Protein level used designations for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase

  • Cas-Br-M (murine) ecotropic retroviral transforming sequence b
  • Cbl proto-oncogene, E3 ubiquitin protein ligase B
  • E3 ubiquitin-protein ligase CBL-B-B
  • SH3-binding protein CBL-B-B
  • signal transduction protein CBL-B-B
  • E3 ubiquitin-protein ligase CBL-B-A
  • SH3-binding protein CBL-B-A
  • signal transduction protein CBL-B-A
  • Casitas B-lineage lymphoma proto-oncogene b
  • E3 ubiquitin-protein ligase CBL-B
  • RING-type E3 ubiquitin transferase CBL-B
  • SH3-binding protein CBL-B
  • Signal transduction protein CBL-B
  • casitas B-lineage lymphoma proto-oncogene b
  • signal transduction protein CBL-B
  • Cas-Br-M (murine) ectropic retroviral transforming sequence b
  • Casitas B-lineage lymphoma b
  • Cbl proto-oncogene B, E3 ubiquitin protein ligase
  • LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B
  • Cas-Br-M ecotropic retroviral transforming sequence b
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