Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Produits
(Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase (CBLB))
Catégories
E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome. Negatively regulates TCR (T-cell receptor), BCR (B- cell receptor) and FCER1 (high affinity immunoglobulin epsilon receptor) signal transduction pathways. In naive T-cells, inhibits VAV1 activation upon TCR engagement and imposes a requirement for CD28 costimulation for proliferation and IL-2 production. Also acts by promoting PIK3R1/p85 ubiquitination, which impairs its recruitment to the TCR and subsequent activation. In activated T- cells, inhibits PLCG1 activation and calcium mobilization upon restimulation and promotes anergy. In B-cells, acts by ubiquitinating SYK and promoting its proteasomal degradation. Slightly promotes SRC ubiquitination. May be involved in EGFR ubiquitination and internalization. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3. {ECO:0000269|PubMed:10646608, ECO:0000269|PubMed:10646609, ECO:0000269|PubMed:11070165, ECO:0000269|PubMed:11526404, ECO:0000269|PubMed:12771181, ECO:0000269|PubMed:15308098}.
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Catégories Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase en vedette
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Anticorps
High quality antibodies with extensive validation data.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Kits ELISA
Reliable ELISA kits for a wide range of species.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN652612
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
N° du produit
ABIN760256
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
N° du produit
ABIN6260515
Quantité
100 μL
Fiche technique
Fiche technique
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6965529
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1131076
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6200984
Quantité
96 tests
Fiche technique
Fiche technique
Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1348172
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122186
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1348174
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
: "Pro-oncogenic Roles of HLXB9 Protein in Insulinoma Cells through Interaction with Nono Protein and Down-regulation of the c-Met Inhibitor Cblb (Casitas B-lineage Lymphoma b)." dans: The Journal of biological chemistry, Vol. 290, Issue 42, pp. 25595-608, (2015) (PubMed).: "Cbl-b mediates TGF? sensitivity by downregulating inhibitory SMAD7 in primary T cells." dans: Journal of molecular cell biology, Vol. 5, Issue 6, pp. 358-68, (2013) (PubMed).
: "The phosphatase and tensin homolog regulates epidermal growth factor receptor (EGFR) inhibitor response by targeting EGFR for degradation. ..." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, Issue 14, pp. 6459-64, (2010) (PubMed).
Synonymes et noms alternatifs relatifs à Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
Cbl proto-oncogene B, E3 ubiquitin protein ligase S homeolog (cblb.S), Cbl proto-oncogene B, E3 ubiquitin protein ligase L homeolog (cblb.L), Casitas B-lineage lymphoma b (Cblb), Cbl proto-oncogene B (Cblb), Cbl proto-oncogene B (CBLB), AI429560, AI851073, Cbl-b, cblb, rnf56Protein level used designations for Cbl Proto-Oncogene B, E3 Ubiquitin Protein Ligase
- Cas-Br-M (murine) ecotropic retroviral transforming sequence b
- Cbl proto-oncogene, E3 ubiquitin protein ligase B
- E3 ubiquitin-protein ligase CBL-B-B
- SH3-binding protein CBL-B-B
- signal transduction protein CBL-B-B
- E3 ubiquitin-protein ligase CBL-B-A
- SH3-binding protein CBL-B-A
- signal transduction protein CBL-B-A
- Casitas B-lineage lymphoma proto-oncogene b
- E3 ubiquitin-protein ligase CBL-B
- RING-type E3 ubiquitin transferase CBL-B
- SH3-binding protein CBL-B
- Signal transduction protein CBL-B
- casitas B-lineage lymphoma proto-oncogene b
- signal transduction protein CBL-B
- Cas-Br-M (murine) ectropic retroviral transforming sequence b
- Casitas B-lineage lymphoma b
- Cbl proto-oncogene B, E3 ubiquitin protein ligase
- LOW QUALITY PROTEIN: E3 ubiquitin-protein ligase CBL-B
- Cas-Br-M ecotropic retroviral transforming sequence b
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