CBP Produits
(CREB Binding Protein (CREBBP))
Catégories
This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB), this gene is now known to play critical roles in embryonic development, growth control, and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain, cysteine-histidine-rich regions, and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2009].
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Catégories CBP en vedette
CBP Anticorps
High quality antibodies with extensive validation data.
CBP Kits ELISA
Reliable ELISA kits for a wide range of species.
CBP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CBP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF, IP, IHC (p), ICC, ChIP
Validations
- (1)
- (9)
- (1)
N° du produit
ABIN2854987
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, ELISA, IF, ICC
Validations
- (5)
N° du produit
ABIN6260516
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, PLA
Validations
- (4)
N° du produit
ABIN560465
Quantité
100 μg
Fiche technique
Fiche technique
CBP recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955103
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955104
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1381381
Quantité
96 tests
Fiche technique
Fiche technique
CBP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122497
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1350309
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (2)
N° du produit
ABIN2669638
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CBP
: "A new cut&run low volume-urea (LoV-U) protocol optimized for transcriptional co-factors uncovers Wnt/b-catenin tissue-specific genomic targets." dans: Development (Cambridge, England), (2022) (PubMed).: "Enriched environment modulates behavior, myelination and augments molecules governing the plasticity in the forebrain region of rats exposed to chronic immobilization stress." dans: Metabolic brain disease, Vol. 34, Issue 3, pp. 875-887, (2020) (PubMed).
: "DYRK1A interacts with histone acetyl transferase p300 and CBP and localizes to enhancers." dans: Nucleic acids research, (2018) (PubMed).
: "Tamoxifen Resistance in Breast Cancer Is Regulated by the EZH2-ERα-GREB1 Transcriptional Axis." dans: Cancer research, Vol. 78, Issue 3, pp. 671-684, (2017) (PubMed).
: "Integrative genome analyses identify key somatic driver mutations of small-cell lung cancer. ..." dans: Nature genetics, Vol. 44, Issue 10, pp. 1104-10, (2012) (PubMed).
: "Protein aggregation in motor neurone disorders." dans: Neuropathology and applied neurobiology, Vol. 29, Issue 6, pp. 529-45, (2003) (PubMed).
Synonymes et noms alternatifs relatifs à CBP
CREB binding protein (CREBBP), CREB binding protein (Crebbp), CREB binding protein L homeolog (crebbp.L), histone acetyltransferase p300 (LOC100123220), AW558298, CBP, cbp, CBP/p300, crebbp, hmm291030, KAT3A, kat3a, Nejire, p300/CBP, RSTS, rsts, RTSProtein level used designations for CBP
- CREB-binding protein
- CREB binding protein (Rubinstein-Taybi syndrome)
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