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CD42b Produits

(Glycoprotein Ib (Platelet), alpha Polypeptide (GP1BA))

Catégories

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Several polymorphisms and mutations have been described in this gene, some of which are the cause of Bernard-Soulier syndromes and platelet-type von Willebrand disease. [provided by RefSeq, Mar 2010].

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Catégories CD42b en vedette

CD42b Anticorps

High quality antibodies with extensive validation data.

CD42b Kits ELISA

Reliable ELISA kits for a wide range of species.

CD42b Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

CD42b recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, FACS, IHC, ELISA, ICC, Neut
Validations
  • (5)
N° du produit ABIN5684108
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC, IP, ICC
Validations
  • (4)
N° du produit ABIN7440512
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, FACS, ELISA, IP, ICC
Validations
  • (2)
  • (2)
N° du produit ABIN2752000
Quantité 0.1 mg
Fiche technique Fiche technique

CD42b recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
  • (1)
N° du produit ABIN6973599
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6960662
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN4882209
Quantité 96 tests
Fiche technique Fiche technique

CD42b recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (3)
N° du produit ABIN7274755
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1355499
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1355497
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits CD42b

Six, Debaene, Van den Hauwe, De Rycke, Gardiner, Compernolle, Feys: "GPIbα shedding in platelets is controlled by strict intracellular containment of both enzyme and substrate." dans: Journal of thrombosis and haemostasis : JTH, (2023) (PubMed).

Carestia, Mena, Olexen, Ortiz Wilczyñski, Negrotto, Errasti, Gómez, Jenne, Carrera Silva, Schattner: "Platelets Promote Macrophage Polarization toward Pro-inflammatory Phenotype and Increase Survival of Septic Mice." dans: Cell reports, Vol. 28, Issue 4, pp. 896-908.e5, (2019) (PubMed).

Chimen, Evryviadou, Box, Harrison, Hazeldine, Dib, Kuravi, Payne, Price, Kavanagh, Iqbal, Lax, Kalia, Brill, Thomas, Belli, Crombie, Adams, Evans, Deckmyn, Lord, Harrison, Watson, Nash, Rainger: "Appropriation of GPIbα from platelet-derived extracellular vesicles supports monocyte recruitment in systemic inflammation." dans: Haematologica, (2019) (PubMed).

Cooper, Lloyd, Koch, Lin, Dobbs, Theisen, Zuberbuehler, Bernhardt, Gyorfi, Tenpas, Hying, Mortimer, Lamont, Lehmann, Neeves: "Temperature effects on the activity, shape, and storage of platelets from 13-lined ground squirrels." dans: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology, Vol. 187, Issue 5-6, pp. 815-825, (2017) (PubMed).

Hu, Fang, Wang, Luk, Thamphiwatana, Dehaini, Nguyen, Angsantikul, Wen, Kroll, Carpenter, Ramesh, Qu, Patel, Zhu, Shi, Hofman, Chen, Gao, Zhang, Chien, Zhang: "Nanoparticle biointerfacing by platelet membrane cloaking." dans: Nature, Vol. 526, Issue 7571, pp. 118-21, (2015) (PubMed).

Monteferrario, Bolar, Marneth, Hebeda, Bergevoet, Veenstra, Laros-van Gorkom, MacKenzie, Khandanpour, Botezatu, Fransen, Van Camp, Duijnhouwer, Salemink, Willemsen, Huls, Preijers, Van Heerde, Jansen et al.: "A dominant-negative GFI1B mutation in the gray platelet syndrome. ..." dans: The New England journal of medicine, Vol. 370, Issue 3, pp. 245-53, (2014) (PubMed).

Ye, Li, Yang, Wang, Hao, Wang, Li, Du, Hao, Liu, Wang, Xia, Huang, Sun, Tian, Fan: "Cytosolic carboxypeptidase CCP6 is required for megakaryopoiesis by modulating Mad2 polyglutamylation." dans: The Journal of experimental medicine, (2014) (PubMed).

Welsh, Colace, Muthard, Stalker, Brass, Diamond: "Platelet-targeting sensor reveals thrombin gradients within blood clots forming in microfluidic assays and in mouse." dans: Journal of thrombosis and haemostasis : JTH, Vol. 10, Issue 11, pp. 2344-53, (2014) (PubMed).

Arlinghaus, Eble: "The collagen-binding integrin α2β1 is a novel interaction partner of the Trimeresurus flavoviridis venom protein flavocetin-A." dans: The Journal of biological chemistry, Vol. 288, Issue 2, pp. 947-55, (2013) (PubMed).

Ishigaki, Miyauchi, Yokoe, Nakayama, Yanagi, Taga, Ohta, Itoh, Ogasawara: "Expression of megakaryocytic and myeloid markers in blasts of transient abnormal myelopoiesis in a stillbirth with Down syndrome: report of histopathological findings of an autopsy case." dans: Human pathology, Vol. 42, Issue 1, pp. 141-5, (2010) (PubMed).

Synonymes et noms alternatifs relatifs à CD42b

glycoprotein Ib platelet alpha subunit (GP1BA), glycoprotein Ib (platelet), alpha polypeptide (GP1BA), glycoprotein Ib platelet alpha subunit (Gp1ba), glycoprotein 1b, alpha polypeptide (Gp1ba), BDPLT1, BDPLT3, BSS, CD42B, CD42b-alpha, DBPLT3, GP1B, GP1BA, GPIbA, GPIba, GPIbalpha, VWDP

Protein level used designations for CD42b

  • GP-Ib alpha
  • antigen CD42b-alpha
  • platelet glycoprotein Ib alpha chain
  • platelet membrane glycoprotein 1b-alpha subunit
  • glycoprotein Ib (platelet), alpha polypeptide
  • platelet glycoprotein Ib alpha polypeptide
  • GPIb-alpha
  • GPIbA
  • glycoprotein Ibalpha
  • glycoprotein 1b, alpha polypeptide
  • platelet glycoprotein Ib alpha chain-like
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