(Cyclin-Dependent Kinase 2 Associated Protein 1 (CDK2AP1))
Catégories
The protein encoded by this gene is a cyclin-dependent kinase 2 (CDK2) -associated protein which is thought to negatively regulate CDK2 activity by sequestering monomeric CDK2, and targeting CDK2 for proteolysis. This protein was found to also interact with DNA polymerase alpha/primase and mediate the phosphorylation of the large p180 subunit, which suggests a regulatory role in DNA replication during the S-phase of the cell cycle. This protein also forms a core subunit of the nucleosome remodeling and histone deacetylation (NURD) complex that epigenetically regulates embryonic stem cell differentiation. This gene thus plays a role in both cell-cycle and epigenetic regulation. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2012].
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Dieterich, Mellberg, Langenkamp, Zhang, Zieba, Salomäki, Teichert, Huang, Edqvist, Kraus, Augustin, Olofsson, Larsson, Söderberg, Molema, Pontén, Georgii-Hemming, Alafuzoff, Dimberg: "Transcriptional profiling of human glioblastoma vessels indicates a key role of VEGF-A and TGFβ2 in vascular abnormalization." dans: The Journal of pathology, Vol. 228, Issue 3, pp. 378-90, (2012) (PubMed).
Synonymes et noms alternatifs relatifs à CDK2AP1
cyclin-dependent kinase 2 associated protein 1 S homeolog (cdk2ap1.S), cyclin dependent kinase 2 associated protein 1 (CDK2AP1), cyclin dependent kinase 2 associated protein 1 pseudogene (LOC475806), cyclin-dependent kinase 2 associated protein 1 (cdk2ap1), CDK2 (cyclin-dependent kinase 2)-associated protein 1 (Cdk2ap1), cyclin-dependent kinase 2 associated protein 1 (Cdk2ap1), cyclin dependent kinase 2 associated protein 1 (Cdk2ap1), Apc10, Cdkap1, doc-1, doc1, Doc1, DOC1, dorc1, DORC1, MGC64532, p12, p12doc-1, p12DOC-1, st19, ST19
Protein level used designations for CDK2AP1
cyclin-dependent kinase 2 associated protein 1
CDK2-associated protein 1
CDK2 (cyclin-dependent kinase 2)-associated protein 1