CDK5R1 Anticorps
(Cyclin-Dependent Kinase 5, Regulatory Subunit 1 (p35) (CDK5R1))
The protein encoded by this gene (p35) is a neuron-specific activator of cyclin-dependent kinase 5 (CDK5)\; the activation of CDK5 is required for proper development of the central nervous system. The p35 form of this protein is proteolytically cleaved by calpain, generating a p25 form. The cleavage of p35 into p25 results in relocalization of the protein from the cell periphery to nuclear and perinuclear regions. P25 deregulates CDK5 activity by prolonging its activation and changing its cellular location. The p25 form accumulates in the brain neurons of patients with Alzheimer's disease. This accumulation correlates with an increase in CDK5 kinase activity, and may lead to aberrantly phosphorylated forms of the microtubule-associated protein tau, which contributes to Alzheimer's disease. [provided by RefSeq, Jul 2008].
Recommandation
CDK5R1 Reactivité: Humain WB, ELISA, IF Hôte: Souris Monoclonal 4G11 unconjugated
CDK5R1 Anticorps par Hote
On trouve ici des CDK5R1 Anticorps avec un Hote spécifique. Les Hote mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits
CDK5R1 Anticorps par Clonalité
Trouvez les CDK5R1 Anticorps monoclonaux ou polyclonaux disponibles. Cliquez sur un lien pour accéder aux produits correspondants.
CDK5R1 Anticorps par Clone
On trouve ici des CDK5R1 Anticorps avec un Clone spécifique. Les Clone mentionnés ici sont quelques-uns de ceux qui sont disponibles. Un clic sur le lien correspondant permet d'accéder aux produits
CDK5R1 Anticorps fréquemment utilisés
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
N° du produit
ABIN2486463
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
N° du produit
ABIN563839
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
N° du produit
ABIN2486459
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
N° du produit
ABIN2486461
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
N° du produit
ABIN2486460
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, IP, ICC, AA
Validations
- (4)
N° du produit
ABIN2486451
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (2)
N° du produit
ABIN7188926
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (2)
N° du produit
ABIN3186243
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (2)
N° du produit
ABIN6258750
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
N° du produit
ABIN1537017
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (2)
N° du produit
ABIN7266592
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB
Validations
- (1)
N° du produit
ABIN6243625
Quantité
80 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC
Validations
- (1)
N° du produit
ABIN3182559
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
ELISA, IHC
Validations
- (1)
N° du produit
ABIN7240319
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB
Validations
- (1)
N° du produit
ABIN7211462
Quantité
200 μL
Fiche technique
Fiche technique
Dernières publications pour nos CDK5R1 Anticorps
: "Ganetespib (STA-9090), a nongeldanamycin HSP90 inhibitor, has potent antitumor activity in in vitro and in vivo models of non-small cell lung cancer." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 18, Issue 18, pp. 4973-85, (2012) (PubMed).: "CDK5 activator p35 downregulates E-cadherin precursor independently of CDK5." dans: FEBS letters, Vol. 582, Issue 8, pp. 1197-202, (2008) (PubMed).
: "Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke." dans: Brain pathology (Zurich, Switzerland), Vol. 17, Issue 1, pp. 11-23, (2007) (PubMed).
: "Increased immunoreactivity of cdk5 activators in hippocampal sclerosis." dans: Neuroreport, Vol. 18, Issue 5, pp. 511-6, (2007) (PubMed).
: "Stable association of hsp90 and p23, but Not hsp70, with active human telomerase." dans: The Journal of biological chemistry, Vol. 276, Issue 19, pp. 15571-4, (2001) (PubMed).
: "The p23 molecular chaperones act at a late step in intracellular receptor action to differentially affect ligand efficacies." dans: Genes & development, Vol. 14, Issue 4, pp. 422-34, (2000) (PubMed).
: "Molecular chaperone machines: chaperone activities of the cyclophilin Cyp-40 and the steroid aporeceptor-associated protein p23." dans: Science (New York, N.Y.), Vol. 274, Issue 5293, pp. 1718-20, (1997) (PubMed).
: "Characterization of a novel 23-kilodalton protein of unactive progesterone receptor complexes." dans: Molecular and cellular biology, Vol. 14, Issue 3, pp. 1956-63, (1994) (PubMed).
Pseudonymes pour CDK5R1 Anticorps
cyclin dependent kinase 5 regulatory subunit 1 (CDK5R1) Anticorpscyclin-dependent kinase 5, regulatory subunit 1b (p35) (cdk5r1b) Anticorps
cyclin-dependent kinase 5 regulatory subunit 1 (Cdk5r1) Anticorps
S100 calcium binding protein A9 (S100A9) Anticorps
cyclin-dependent kinase 5, regulatory subunit 1 (p35) (Cdk5r1) Anticorps
cyclin-dependent kinase 5, regulatory subunit 1 (p35) L homeolog (cdk5r1.L) Anticorps
cyclin dependent kinase 5 regulatory subunit 1 (Cdk5r1) Anticorps
CDK5P35 Anticorps
CDK5R Anticorps
Cdk5r Anticorps
cdk5r1 Anticorps
CDK5R1 Anticorps
D11Bwg0379e Anticorps
NCK5A Anticorps
p23 Anticorps
p25 Anticorps
P25/P35 Anticorps
p35 Anticorps
p35nck5a Anticorps
Xp35.1 Anticorps
zgc:92814 Anticorps
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