CDKN2B Produits
(Cyclin-Dependent Kinase Inhibitor 2B (p15, Inhibits CDK4) (CDKN2B))
Catégories
This gene lies adjacent to the tumor suppressor gene CDKN2A in a region that is frequently mutated and deleted in a wide variety of tumors. This gene encodes a cyclin-dependent kinase inhibitor, which forms a complex with CDK4 or CDK6, and prevents the activation of the CDK kinases, thus the encoded protein functions as a cell growth regulator that controls cell cycle G1 progression. The expression of this gene was found to be dramatically induced by TGF beta, which suggested its role in the TGF beta induced growth inhibition. Two alternatively spliced transcript variants of this gene, which encode distinct proteins, have been reported. [provided by RefSeq, Jul 2008].
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Catégories CDKN2B en vedette
CDKN2B Anticorps
High quality antibodies with extensive validation data.
CDKN2B Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CDKN2B recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF, IHC (p)
Validations
- (6)
N° du produit
ABIN1497447
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF, FACS
Validations
- (7)
N° du produit
ABIN3030647
Quantité
0.4 mL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (4)
N° du produit
ABIN7182212
Quantité
100 μL
Fiche technique
Fiche technique
CDKN2B recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1349020
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7419952
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3090897
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits CDKN2B
: "ANRIL inhibits p15(INK4b) through the TGFβ1 signaling pathway in human esophageal squamous cell carcinoma." dans: Cellular immunology, Vol. 289, Issue 1-2, pp. 91-6, (2014) (PubMed).: "Phospho-?Np63?-dependent microRNAs modulate chemoresistance of squamous cell carcinoma cells to cisplatin: at the crossroads of cell life and death." dans: FEBS letters, Vol. 587, Issue 16, pp. 2536-41, (2013) (PubMed).
: "Hiwi mediated tumorigenesis is associated with DNA hypermethylation." dans: PLoS ONE, Vol. 7, Issue 3, pp. e33711, (2012) (PubMed).
: "Strategies to re-express epigenetically silenced p15(INK4b) and p21(WAF1) genes in acute myeloid leukemia." dans: Epigenetics, Vol. 5, Issue 8, pp. 696-703, (2010) (PubMed).
: "Iron chelation-induced senescence-like growth arrest in hepatocyte cell lines: association of transforming growth factor beta1 (TGF-beta1)-mediated p27Kip1 expression." dans: The Biochemical journal, Vol. 366, Issue Pt 2, pp. 613-21, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à CDKN2B
cyclin dependent kinase inhibitor 2B (CDKN2B), Cyclin-dependent kinase 4 inhibitor B (cdn2b), cyclin-dependent kinase inhibitor 2B (cdkn2b), cyclin-dependent kinase inhibitor 2B L homeolog (cdkn2b.L), cyclin-dependent kinase inhibitor 2B (p15, inhibits CDK4) (Cdkn2b), cyclin-dependent kinase inhibitor 2B (Cdkn2b), AV083695, CDK4I, cdk4l, CDKN2A, ink4b, INK4B, INK4b, mts2, MTS2, p14-INK4b, p15, P15, p15(INK4b), p15ink4b, p15INK4b, tp15, TP15Protein level used designations for CDKN2B
- Cyclin-dependent kinase 4 inhibitor B
- CDK inhibitory protein
- CDK4B inhibitor
- MTS-2
- cyclin-dependent kinase 4 inhibitor B
- cyclin-dependent kinases 4 and 6 binding protein
- multiple tumor suppressor 2
- p14-INK4b
- p14_CDK inhibitor
- p14_INK4B
- p15 CDK inhibitor
- p15-INK4b
- p15_INK4B
- cyclin-dependent kinase inhibitor p15
- cyclin-dependent kinase inhibitor p15INK4b
- cyclin-dependent kinase inhibitor protein
- Cyclin dependent kinase inhibitor 2B (p15, inhibits CDK4)
- cyclin dependant kinase inhibitor
- cyclin-dependent kinase inhibitor 2A (melanoma, p16, inhibits CDK4)
- cyclin-dependent kinase inhibitor 2B
- cyclin-dependent kinase inhibitor 2B (melanoma, p16, inhibits CDK4)
- p15INK4b tumor suppressor
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