CDT2/RAMP Produits
(Denticleless E3 Ubiquitin Protein Ligase Homolog (DTL))
Catégories
Substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control, DNA damage response and translesion DNA synthesis. The DCX(DTL) complex, also named CRL4(CDT2) complex, mediates the polyubiquitination and subsequent degradation of CDT1 and CDKN1A/p21(CIP1). CDT1 degradation in response to DNA damage is necessary to ensure proper cell cycle regulation of DNA replication. CDKN1A/p21(CIP1) degradation during S phase or following UV irradiation is essential to control replication licensing. Most substrates require their interaction with PCNA for PIP-box, and those containing the 'K+4' motif in the PIP box, recruit the DCX(DTL) complex, leading to their degradation. In undamaged proliferating cells, the DCX(DTL) complex also promotes the 'Lys-164' monoubiquitination of PCNA, thereby being involved in PCNA-dependent translesion DNA synthesis (By similarity).
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Catégories CDT2/RAMP en vedette
CDT2/RAMP Anticorps
High quality antibodies with extensive validation data.
CDT2/RAMP Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CDT2/RAMP recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7149691
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, FACS
Validations
- (2)
N° du produit
ABIN654926
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (2)
N° du produit
ABIN949333
Quantité
100 μg
Fiche technique
Fiche technique
CDT2/RAMP recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3092255
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3134980
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN5505614
Quantité
50 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CDT2/RAMP
: "Tumor suppressor protein Lgl mediates G1 cell cycle arrest at high cell density by forming an Lgl-VprBP-DDB1 complex." dans: Molecular biology of the cell, Vol. 26, Issue 13, pp. 2426-38, (2015) (PubMed).: "Overexpression of denticleless E3 ubiquitin protein ligase homolog (DTL) is related to poor outcome in gastric carcinoma." dans: Oncotarget, Vol. 6, Issue 34, pp. 36615-24, (2015) (PubMed).
: "Interactions between the otitis media gene, Fbxo11, and p53 in the mouse embryonic lung." dans: Disease models & mechanisms, Vol. 8, Issue 12, pp. 1531-42, (2015) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." dans: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "SET8 is degraded via PCNA-coupled CRL4(CDT2) ubiquitylation in S phase and after UV irradiation." dans: The Journal of cell biology, Vol. 192, Issue 1, pp. 43-54, (2011) (PubMed).
: "Prognostic significance of miR-215 in colon cancer." dans: Clinical colorectal cancer, Vol. 10, Issue 4, pp. 340-7, (2011) (PubMed).
: "PCNA-dependent regulation of p21 ubiquitylation and degradation via the CRL4Cdt2 ubiquitin ligase complex." dans: Genes & development, Vol. 22, Issue 18, pp. 2496-506, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à CDT2/RAMP
denticleless E3 ubiquitin protein ligase homolog (DTL), denticleless E3 ubiquitin protein ligase (Dtl), denticleless E3 ubiquitin protein ligase homolog (Dtl), denticleless E3 ubiquitin protein ligase homolog S homeolog (dtl.S), denticleless E3 ubiquitin protein ligase homolog (Drosophila) (dtl), 2810047L02Rik, 5730564G15Rik, cb151, CDT2, cdt2, cdt2-a, chunp6871, DCAF2, dcaf2, L2DTL, l2dtl, RAMP, Ramp, ramp, RGD1310439, wu:fb54b02Protein level used designations for CDT2/RAMP
- DDB1 and CUL4 associated factor 2
- DDB1- and CUL4-associated factor 2
- RA regulated nuclear matrix associated protein
- RA-regulated nuclear matrix-associated protein
- denticleless homolog
- denticleless protein homolog
- lethal(2) denticleless protein homolog
- retinoic acid-regulated nuclear matrix-associated protein
- Meth A ramp
- meth A retinoic acid-regulated nuclear matrix-associated protein
- retinoic-acid regulated nuclear matrix-associated protein
- denticleless protein homolog A
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