CHRNA7 Produits
(Cholinergic Receptor, Nicotinic, alpha 7 (Neuronal) (CHRNA7))
Catégories
The nicotinic acetylcholine receptors (nAChRs) are members of a superfamily of ligand-gated ion channels that mediate fast signal transmission at synapses. The nAChRs are thought to be hetero-pentamers composed of homologous subunits. The proposed structure for each subunit is a conserved N-terminal extracellular domain followed by three conserved transmembrane domains, a variable cytoplasmic loop, a fourth conserved transmembrane domain, and a short C-terminal extracellular region. The protein encoded by this gene forms a homo-oligomeric channel, displays marked permeability to calcium ions and is a major component of brain nicotinic receptors that are blocked by, and highly sensitive to, alpha-bungarotoxin. Once this receptor binds acetylcholine, it undergoes an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. This gene is located in a region identified as a major susceptibility locus for juvenile myoclonic epilepsy and a chromosomal location involved in the genetic transmission of schizophrenia. An evolutionarily recent partial duplication event in this region results in a hybrid containing sequence from this gene and a novel FAM7A gene. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012].
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Catégories CHRNA7 en vedette
CHRNA7 Anticorps
High quality antibodies with extensive validation data.
CHRNA7 Kits ELISA
Reliable ELISA kits for a wide range of species.
CHRNA7 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CHRNA7 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
ELISA, IHC, FACS
Validations
- (3)
- (7)
N° du produit
ABIN5611363
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IF (cc), IF (p), ICC, IHC (p), IHC (fro)
Validations
- (5)
N° du produit
ABIN736911
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, FACS
Validations
- (5)
N° du produit
ABIN5611362
Quantité
100 μL
Fiche technique
Fiche technique
CHRNA7 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954757
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN418014
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN5595336
Quantité
96 tests
Fiche technique
Fiche technique
CHRNA7 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122359
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
N° du produit
ABIN7508493
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7413079
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CHRNA7
: "Extracellular Vesicles Derived from Metastatic Melanoma Cells Transfer α7-nAChR mRNA, Thus Increasing the Surface Expression of the Receptor and Stimulating the Growth of Normal Keratinocytes." dans: Acta naturae, Vol. 14, Issue 3, pp. 95-99, (2022) (PubMed).: "SLURP-1 Controls Growth and Migration of Lung Adenocarcinoma Cells, Forming a Complex With α7-nAChR and PDGFR/EGFR Heterodimer." dans: Frontiers in cell and developmental biology, Vol. 9, pp. 739391, (2021) (PubMed).
: "Human Three-Finger Protein Lypd6 Is a Negative Modulator of the Cholinergic System in the Brain." dans: Frontiers in cell and developmental biology, Vol. 9, pp. 662227, (2021) (PubMed).
: "Evaluating Commercially Available Antibodies for Rat α7 Nicotinic Acetylcholine Receptors." dans: The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society, Vol. 65, Issue 9, pp. 499-512, (2017) (PubMed).
: "Mechanisms of tumor-promoting activities of nicotine in lung cancer: synergistic effects of cell membrane and mitochondrial nicotinic acetylcholine receptors." dans: BMC cancer, Vol. 15, pp. 152, (2015) (PubMed).
: "Molecular mechanisms of synergy of corneal muscarinic and nicotinic acetylcholine receptors in upregulation of E-cadherin expression." dans: International immunopharmacology, Vol. 29, Issue 1, pp. 15-20, (2015) (PubMed).
: "Different dynamics of aquaporin 4 and glutamate transporter-1 distribution in the perineuronal and perivascular compartments during ischemic stroke." dans: Brain pathology (Zurich, Switzerland), Vol. 24, Issue 5, pp. 475-93, (2014) (PubMed).
: "Increased antibodies for the alpha7 subunit of the nicotinic receptor in schizophrenia." dans: Schizophrenia research, Vol. 109, Issue 1-3, pp. 98-101, (2009) (PubMed).
: "{alpha}7 nicotinic acetylcholine receptor regulates airway epithelium differentiation by controlling basal cell proliferation." dans: The American journal of pathology, Vol. 175, Issue 5, pp. 1868-82, (2009) (PubMed).
: "The alpha7 nicotinic acetylcholine receptor subunit exists in two isoforms that contribute to functional ligand-gated ion channels." dans: Molecular pharmacology, Vol. 66, Issue 3, pp. 420-9, (2004) (PubMed).
Synonymes et noms alternatifs relatifs à CHRNA7
cholinergic receptor nicotinic alpha 7 subunit (CHRNA7), neuronal acetylcholine receptor subunit alpha-7 (LOC100374356), cholinergic receptor, nicotinic, alpha 7 (neuronal) (chrna7), cholinergic receptor, nicotinic, alpha polypeptide 7 (Chrna7), cholinergic receptor nicotinic alpha 7 subunit (Chrna7), cholinergic receptor, nicotinic, alpha 7 (CHRNA7), neuronal acetylcholine receptor subunit alpha-7 (LOC100060521), Acra7, alpha7, BTX, CHRNA7, CHRNA7-2, dZ70B1.1, NACHRA7, nAChRa7, NARADProtein level used designations for CHRNA7
- a7 nicotinic acetylcholine receptor
- alpha 7 neuronal nicotinic acetylcholine receptor
- alpha-7 nicotinic cholinergic receptor subunit
- cholinergic receptor, nicotinic, alpha polypeptide 7
- neuronal acetylcholine receptor protein, alpha-7 chain
- neuronal acetylcholine receptor subunit alpha-7
- cholinergic receptor, nicotinic, alpha 7
- neuronal acetylcholine receptor subunit alpha-7-like
- acetylcholine receptor alpha 7 neural
- alpha7 nicotinic receptor
- alpha7-nAChR
- C holinergic receptor nicotinic alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
- C holinergic receptor, nicotinic, alpha polypeptide 7 (neuronal nicotinic acetycholine receptor alpha 7) (bungarotoxin alpha)
- bungarotoxin alpha
- neuronal nicotinic acetycholine receptor alpha 7
- nicotinic receptor alpha 7 subunit
- cholinergic receptor nicotinic alpha 7
- alpha 7 nicotinic acetylcholine receptor
- nicotinic acetylcholine receptor alpha7
- CHRNA7-FAM7A fusion protein
- cholinergic receptor, nicotinic, alpha 7 (neuronal)
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- Chromatin Target of PRMT1
- Chromogranin A
- Chromosome 1 Open Reading Frame 190
- Chromosome 1 Open Reading Frame 27
- Chromosome 1 Open Reading Frame 61
- Chromosome 1 Open Reading Frame 84
- Chromosome 10 Open Reading Frame 116
- Chromosome 11open Reading Frame 9
- Chromosome 12 Open Reading Frame 39
- Chromosome 12 Open Reading Frame 52
- Chromosome 12 Open Reading Frame 57
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