CIITA Produits
(Class II, Major Histocompatibility Complex, Transactivator (CIITA))
Catégories
This gene encodes a protein with an acidic transcriptional activation domain, 4 LRRs (leucine-rich repeats) and a GTP binding domain. The protein is located in the nucleus and acts as a positive regulator of class II major histocompatibility complex gene transcription, and is referred to as the 'master control factor' for the expression of these genes. The protein also binds GTP and uses GTP binding to facilitate its own transport into the nucleus. Once in the nucleus it does not bind DNA but rather uses an intrinsic acetyltransferase (AT) activity to act in a coactivator-like fashion. Mutations in this gene have been associated with bare lymphocyte syndrome type II (also known as hereditary MHC class II deficiency or HLA class II-deficient combined immunodeficiency), increased susceptibility to rheumatoid arthritis, multiple sclerosis, and possibly myocardial infarction. [provided by RefSeq, Jul 2008].
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Catégories CIITA en vedette
CIITA Anticorps
High quality antibodies with extensive validation data.
CIITA Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CIITA recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC (p)
Validations
- (1)
- (4)
N° du produit
ABIN4886541
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Pig
Application
WB
Validations
- (3)
- (1)
N° du produit
ABIN97339
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (2)
N° du produit
ABIN6257104
Quantité
100 μL
Fiche technique
Fiche technique
CIITA recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1349483
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3090387
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3134669
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits CIITA
: "A super enhancer controls expression and chromatin architecture within the MHC class II locus." dans: The Journal of experimental medicine, Vol. 217, Issue 2, (2020) (PubMed).: "Class II transactivator knockdown limits major histocompatibility complex II expression, diminishes immune rejection, and improves survival of allogeneic bone marrow stem cells in the infarcted heart." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 30, Issue 9, pp. 3069-82, (2016) (PubMed).
: "Autoregulatory loop between TGF-β1/miR-411-5p/SPRY4 and MAPK pathway in rhabdomyosarcoma modulates proliferation and differentiation." dans: Cell death & disease, Vol. 6, pp. e1859, (2016) (PubMed).
: "Genome-wide CIITA-binding profile identifies sequence preferences that dictate function versus recruitment." dans: Nucleic acids research, Vol. 43, Issue 6, pp. 3128-42, (2015) (PubMed).
: "Pollen-induced antigen presentation by mesenchymal stem cells and T cells from allergic rhinitis." dans: Clinical & translational immunology, Vol. 2, Issue 10, pp. e7, (2014) (PubMed).
: "The 19S proteasome positively regulates histone methylation at cytokine inducible genes." dans: Biochimica et biophysica acta, Vol. 1789, Issue 11-12, pp. 691-701, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à CIITA
class II, major histocompatibility complex, transactivator (CIITA), class II major histocompatibility complex transactivator (CIITA), MHC class II transactivator (LOC710761), class II, major histocompatibility complex, transactivator (ciita), MHC class II transactivator (LOC100443575), class II transactivator (Ciita), MHC class II transactivator (LOC100736732), class II, major histocompatibility complex, transactivator (Ciita), C2ta, C2TA, CIITA, CIITAIV, EG669998, Gm9475, MHC2TA, Mhc2ta, NLRAProtein level used designations for CIITA
- class II, major histocompatibility complex, transactivator
- class II transactivator-like
- class II transactivator
- MHC class II transactivator-like
- MHC class II transactivator
- MHC class II transactivator type III
- NLR family, acid domain containing
- nucleotide-binding oligomerization domain, leucine rich repeat and acid domain containing
- MHC class II transactivator type IV
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