(C-Type Lectin Domain Family 12, Member A (CLEC12A))
Catégories
This gene encodes a member of the C-type lectin/C-type lectin-like domain (CTL/CTLD) superfamily. Members of this family share a common protein fold and have diverse functions, such as cell adhesion, cell-cell signaling, glycoprotein turnover, and roles in inflammation and immune response. The protein encoded by this gene is a negative regulator of granulocyte and monocyte function. Several alternatively spliced transcript variants of this gene have been described, but the full-length nature of some of these variants has not been determined. This gene is closely linked to other CTL/CTLD superfamily members in the natural killer gene complex region on chromosome 12p13. [provided by RefSeq, May 2011].
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Hutten, Thordardottir, Fredrix, Janssen, Woestenenk, Tel, Joosten, Cambi, Heemskerk, Franssen, Boerman, Bakker, Jansen, Schaap, Dolstra, Hobo: "CLEC12A-Mediated Antigen Uptake and Cross-Presentation by Human Dendritic Cell Subsets Efficiently Boost Tumor-Reactive T Cell Responses." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 197, Issue 7, pp. 2715-25, (2016) (PubMed).
Neumann, Castiñeiras-Vilariño, Höckendorf, Hannesschläger, Lemeer, Kupka, Meyermann, Lech, Anders, Kuster, Busch, Gewies, Naumann, Groß, Ruland: "Clec12a is an inhibitory receptor for uric acid crystals that regulates inflammation in response to cell death." dans: Immunity, Vol. 40, Issue 3, pp. 389-99, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à CLEC12A
C-type lectin domain family 12 member A (CLEC12A), C-type lectin domain family 12, member a (Clec12a), C-type lectin domain family 12, member A (Clec12a), CLL-1, CLL1, D230024O04, DCAL-2, KLRL1, MGC179455, MICL, Micl