CNTNAP2 Produits
(Contactin Associated Protein-Like 2 (CNTNAP2))
Catégories
This gene encodes a member of the neurexin family which functions in the vertebrate nervous system as cell adhesion molecules and receptors. This protein, like other neurexin proteins, contains epidermal growth factor repeats and laminin G domains. In addition, it includes an F5/8 type C domain, discoidin/neuropilin- and fibrinogen-like domains, thrombospondin N-terminal-like domains and a putative PDZ binding site. This protein is localized at the juxtaparanodes of myelinated axons, and mediates interactions between neurons and glia during nervous system development and is also involved in localization of potassium channels within differentiating axons. This gene encompasses almost 1.5% of chromosome 7 and is one of the largest genes in the human genome. It is directly bound and regulated by forkhead box protein P2 (FOXP2), a transcription factor related to speech and language development. This gene has been implicated in multiple neurodevelopmental disorders, including Gilles de la Tourette syndrome, schizophrenia, epilepsy, autism, ADHD and mental retardation.[provided by RefSeq, Mar 2010].
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Catégories CNTNAP2 en vedette
CNTNAP2 Anticorps
High quality antibodies with extensive validation data.
CNTNAP2 Kits ELISA
Reliable ELISA kits for a wide range of species.
CNTNAP2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CNTNAP2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
N° du produit
ABIN652646
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP
Validations
- (2)
N° du produit
ABIN949170
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
WB, ELISA, FACS
Validations
- (1)
N° du produit
ABIN1386423
Quantité
100 μL
Fiche technique
Fiche technique
CNTNAP2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966064
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6730471
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4882106
Quantité
96 tests
Fiche technique
Fiche technique
CNTNAP2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN7320203
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7413064
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
N° du produit
ABIN7538789
Quantité
2 x 100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CNTNAP2
: "Synaptic abnormalities and cytoplasmic glutamate receptor aggregates in contactin associated protein-like 2/Caspr2 knockout neurons." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 112, Issue 19, pp. 6176-81, (2015) (PubMed).: "Interaction proteomics of canonical Caspr2 (CNTNAP2) reveals the presence of two Caspr2 isoforms with overlapping interactomes." dans: Biochimica et biophysica acta, Vol. 1854, Issue 7, pp. 827-33, (2015) (PubMed).
: "Generation of inner ear sensory epithelia from pluripotent stem cells in 3D culture." dans: Nature, Vol. 500, Issue 7461, pp. 217-21, (2013) (PubMed).
: "Morvan syndrome: clinical and serological observations in 29 cases." dans: Annals of neurology, Vol. 72, Issue 2, pp. 241-55, (2012) (PubMed).
: "Clustering and activity tuning of Kv1 channels in myelinated hippocampal axons." dans: The Journal of biological chemistry, Vol. 286, Issue 29, pp. 25835-47, (2011) (PubMed).
: "Molecular microdomains in a sensory terminal, the vestibular calyx ending." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 31, Issue 27, pp. 10101-14, (2011) (PubMed).
: "Genome-wide association study with DNA pooling identifies variants at CNTNAP2 associated with pseudoexfoliation syndrome." dans: European journal of human genetics : EJHG, Vol. 19, Issue 2, pp. 186-93, (2011) (PubMed).
: "Organization of myelinated axons by Caspr and Caspr2 requires the cytoskeletal adapter protein 4.1B." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 30, Issue 7, pp. 2480-9, (2010) (PubMed).
: "Human myelin proteome and comparative analysis with mouse myelin." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14605-10, (2009) (PubMed).
Synonymes et noms alternatifs relatifs à CNTNAP2
contactin associated protein like 2 (CNTNAP2), contactin associated protein-like 2 (Cntnap2), contactin associated protein-like 2 (CNTNAP2), contactin associated protein like 2b (cntnap2b), contactin associated protein like 2 (cntnap2), contactin associated protein like 2 (Cntnap2), 5430425M22Rik, AUTS15, CASPR, CASPR2, Caspr2, CDFE, MGC145769, MGC147944, MGC147981, mKIAA0868, NRXN4, PTHSL1Protein level used designations for CNTNAP2
- cell recognition molecule Caspr2
- contactin-associated protein-like 2
- homolog of Drosophila neurexin IV
- contactin associated protein-like 2
- novel protein similar to H.sapiens contactin associated protein
- contactin associated protein 2
- contactin-associated protein-like 2-like
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