COCH Produits
(Cochlin (COCH))
Catégories
The protein encoded by this gene is highly conserved in human, mouse, and chicken, showing 94% and 79% amino acid identity of human to mouse and chicken sequences, respectively. Hybridization to this gene was detected in spindle-shaped cells located along nerve fibers between the auditory ganglion and sensory epithelium. These cells accompany neurites at the habenula perforata, the opening through which neurites extend to innervate hair cells. This and the pattern of expression of this gene in chicken inner ear paralleled the histologic findings of acidophilic deposits, consistent with mucopolysaccharide ground substance, in temporal bones from DFNA9 (autosomal dominant nonsyndromic sensorineural deafness 9) patients. Mutations that cause DFNA9 have been reported in this gene. Alternative splicing results in multiple transcript variants encoding the same protein. Additional splice variants encoding distinct isoforms have been described but their biological validities have not been demonstrated. [provided by RefSeq, Oct 2008].
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Catégories COCH en vedette
COCH Anticorps
High quality antibodies with extensive validation data.
COCH Kits ELISA
Reliable ELISA kits for a wide range of species.
COCH Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
COCH recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN656833
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7148039
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB
Validations
- (2)
N° du produit
ABIN655279
Quantité
400 μL
Fiche technique
Fiche technique
COCH recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6954851
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4882435
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6386083
Quantité
96 tests
Fiche technique
Fiche technique
COCH recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1349913
Quantité
25 μg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
HEK-293 Cells
Validations
N° du produit
ABIN6253496
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
N° du produit
ABIN6253494
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits COCH
: "Cleaved Cochlin Sequesters Pseudomonas aeruginosa and Activates Innate Immunity in the Inner Ear." dans: Cell host & microbe, Vol. 25, Issue 4, pp. 513-525.e6, (2019) (PubMed).: "Activation of human endothelial cells via S-endo-1 antigen (CD146) stimulates the tyrosine phosphorylation of focal adhesion kinase p125(FAK)." dans: The Journal of biological chemistry, Vol. 273, Issue 41, pp. 26852-6, (1998) (PubMed).
: "Loss of AP-2 results in up-regulation of MCAM/MUC18 and an increase in tumor growth and metastasis of human melanoma cells." dans: The Journal of biological chemistry, Vol. 273, Issue 26, pp. 16501-8, (1998) (PubMed).
: "Expression of MCAM/MUC18 by human melanoma cells leads to increased tumor growth and metastasis." dans: Cancer research, Vol. 57, Issue 11, pp. 2295-303, (1997) (PubMed).
: "MUC18, a marker of tumor progression in human melanoma, shows sequence similarity to the neural cell adhesion molecules of the immunoglobulin superfamily." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 86, Issue 24, pp. 9891-5, (1990) (PubMed).
Synonymes et noms alternatifs relatifs à COCH
cochlin (Coch), cochlin (COCH), AW122937, Coch-5B2, COCH-5B2, COCH5B2, D12H14S564E, DFNA9Protein level used designations for COCH
- coagulation factor C homolog (Limulus polyphemus)
- coagulation factor C homolog, cochlin (Limulus polyphemus)
- cochlin
- Coch-5B2
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- COA6
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- CO5A2
- Co-Chaperonin GroES
- CNTROB
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