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Cullin 1 Produits

(Cullin 1 (CUL1))
Core component of multiple cullin-RING-based SCF (SKP1- CUL1-F-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as a rigid scaffold that organizes the SKP1-F-box protein and RBX1 subunits. May contribute to catalysis through positioning of the substrate and the ubiquitin-conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC) directs ubiquitination of NFKBIB, NFKBIE, ATF4, SMAD3, SMAD4, CDC25A, FBXO5 and probably NFKB2. SCF(SKP2) directs ubiquitination of phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. SCF(SKP2) directs ubiquitination of ORC1, CDT1, RBL2, ELF4, CDKN1A, RAG2, FOXO1A, and probably MYC and TAL1. SCF(FBXW7) directs ubiquitination of cyclin E, NOTCH1 released notch intracellular domain (NICD), and probably PSEN1. SCF(FBXW2) directs ubiquitination of GCM1. SCF(FBXO32) directs ubiquitination of MYOD1. SCF(FBXO7) directs ubiquitination of BIRC2 and DLGAP5. SCF(FBXO33) directs ubiquitination of YBX1. SCF(FBXO11) does not seem to direct ubiquitination of TP53. SCF(BTRC) mediates the ubiquitination of NFKBIA at 'Lys-21' and 'Lys-22'\; the degradation frees the associated NFKB1-RELA dimer to translocate into the nucleus and to activate transcription. SCF(Cyclin F) directs ubiquitination of CP110 (By similarity).

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Catégories Cullin 1 en vedette

Cullin 1 Anticorps

High quality antibodies with extensive validation data.

Cullin 1 Kits ELISA

Reliable ELISA kits for a wide range of species.

Cullin 1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

Cullin 1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IF
Validations
  • (2)
  • (6)
N° du produit ABIN3015864
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC, IF
Validations
  • (4)
N° du produit ABIN7180924
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, ELISA, IHC, IF, ICC
Validations
  • (4)
N° du produit ABIN6261114
Quantité 100 μL
Fiche technique Fiche technique

Cullin 1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Analytical Method Qualitative Cell ELISA
Validations
N° du produit ABIN1381059
Quantité 96 tests
Fiche technique Fiche technique

Cullin 1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1350756
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7122515
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN667243
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits Cullin 1

Mao, Xiong, Huang, Zheng, Yao: "Expression of CUL1 correlates with tumour-grade and recurrence in urothelial carcinoma." dans: ANZ journal of surgery, Vol. 87, Issue 7-8, pp. 624-629, (2018) (PubMed).

Benesova, Kinterova, Kanka, Toralova: "Potential Involvement of SCF-Complex in Zygotic Genome Activation During Early Bovine Embryo Development." dans: Methods in molecular biology (Clifton, N.J.), Vol. 1605, pp. 245-257, (2018) (PubMed).

Chen, Xu, Yang, Zhang, Wu, Chen, Li, Wang, Li, Li, Dai: "Upregulation of miR-223 in the rat liver inhibits proliferation of hepatocytes under simulated microgravity." dans: Experimental & molecular medicine, Vol. 49, Issue 6, pp. e348, (2018) (PubMed).

Lutz, Pace, Arnold: "Rotavirus NSP1 Associates with Components of the Cullin RING Ligase Family of E3 Ubiquitin Ligases." dans: Journal of virology, Vol. 90, Issue 13, pp. 6036-48, (2016) (PubMed).

Liao, Jiang, He, Ni, Tu, Zhang, Wang, Lou, Quan, Wang: "NEDD8-mediated neddylation is required for human endometrial stromal proliferation and decidualization." dans: Human reproduction (Oxford, England), Vol. 30, Issue 7, pp. 1665-76, (2016) (PubMed).

Jiang, He, Xu, Liu, Qu, Tong: "Cullin-1 promotes cell proliferation via cell cycle regulation and is a novel in prostate cancer." dans: International journal of clinical and experimental pathology, Vol. 8, Issue 2, pp. 1575-83, (2015) (PubMed).

Wang, Zhao, Zhao, Zhang, Gao: "TRIM26 negatively regulates interferon-β production and antiviral response through polyubiquitination and degradation of nuclear IRF3." dans: PLoS pathogens, Vol. 11, Issue 3, pp. e1004726, (2015) (PubMed).

Mallampalli, Glasser, Coon, Chen: "Calmodulin protects Aurora B on the midbody to regulate the fidelity of cytokinesis." dans: Cell cycle (Georgetown, Tex.), Vol. 12, Issue 4, pp. 663-73, (2013) (PubMed).

Enchev, Scott, da Fonseca, Schreiber, Monda, Schulman, Peter, Morris: "Structural basis for a reciprocal regulation between SCF and CSN." dans: Cell reports, Vol. 2, Issue 3, pp. 616-27, (2012) (PubMed).

Duda, Borg, Scott, Hunt, Hammel, Schulman: "Structural insights into NEDD8 activation of cullin-RING ligases: conformational control of conjugation." dans: Cell, Vol. 134, Issue 6, pp. 995-1006, (2008) (PubMed).

Synonymes et noms alternatifs relatifs à Cullin 1

cullin 1 (CUL1), cullin-1 (LOC100282292), cullin 1 (cul1), cullin-1 (ATEG_00491), cullin-1 (EDI_072700), cullin-1 (EDI_264400), Cullin 1 (SJAG_02591), Cullin-1 (BDBG_03785), cullin 1 (Cul1), cullin 1a (cul1a), cullin 1 S homeolog (cul1.S), Cullin-1 (cul-1), cullin 1b (cul1b), ATCUL1, AUXIN RESISTANT 6, AXR6, Cul-1, Cul1, cul1, Cullin-1, cullin-1, cullin 1, LOC100282292, T10P11.26, T10P11_26, wu:fc13a10, wu:fi43h07, wu:fj43a08, zgc:55483, zgc:55747, zgc:77500, zgc:111899

Protein level used designations for Cullin 1

  • CUL-1
  • cullin-1
  • Cullin-1
  • Cell division control 53 homolog
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