Cullin 2 Produits
(Cullin 2 (CUL2))
Catégories
Core component of multiple cullin-RING-based ECS (ElonginB/C-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination of target proteins. May serve as a rigid scaffold in the complex and may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating enzyme. The E3 ubiquitin-protein ligase activity of the complex is dependent on the neddylation of the cullin subunit and is inhibited by the association of the deneddylated cullin subunit with TIP120A/CAND1 (By similarity). The functional specificity of the ECS complex depends on the substrate recognition component. ECS(VHL) mediates the ubiquitination of hypoxia-inducible factor (HIF).
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Catégories Cullin 2 en vedette
Cullin 2 Anticorps
High quality antibodies with extensive validation data.
Cullin 2 Kits ELISA
Reliable ELISA kits for a wide range of species.
Cullin 2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Cullin 2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF, ICC
Validations
- (1)
- (5)
N° du produit
ABIN6261115
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Dog, Human, Mouse, Rat
Application
WB, IHC, IF, IP
Validations
- (2)
- (4)
N° du produit
ABIN968173
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, IF
Validations
- (2)
N° du produit
ABIN7184770
Quantité
100 μg
Fiche technique
Fiche technique
Cullin 2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse
Analytical Method
Qualitative Cell ELISA
Validations
N° du produit
ABIN1381060
Quantité
96 tests
Fiche technique
Fiche technique
Cullin 2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1350758
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1350760
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7423426
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Cullin 2
: "Twist1 Regulates Vimentin through Cul2 Circular RNA to Promote EMT in Hepatocellular Carcinoma." dans: Cancer research, Vol. 78, Issue 15, pp. 4150-4162, (2018) (PubMed).: "KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise." dans: Physiological genomics, Vol. 36, Issue 2, pp. 79-88, (2009) (PubMed).
: "TBP-interacting protein 120B (TIP120B)/cullin-associated and neddylation-dissociated 2 (CAND2) inhibits SCF-dependent ubiquitination of myogenin and accelerates myogenic differentiation." dans: The Journal of biological chemistry, Vol. 282, Issue 12, pp. 9017-28, (2007) (PubMed).
: "COMMD1 promotes the ubiquitination of NF-kappaB subunits through a cullin-containing ubiquitin ligase." dans: The EMBO journal, Vol. 26, Issue 2, pp. 436-47, (2007) (PubMed).
: "Perturbation of SUMOlation enzyme Ubc9 by distinct domain within nucleoporin RanBP2/Nup358." dans: The Journal of biological chemistry, Vol. 277, Issue 7, pp. 4755-63, (2002) (PubMed).
: "CUL-2 is required for the G1-to-S-phase transition and mitotic chromosome condensation in Caenorhabditis elegans." dans: Nature cell biology, Vol. 1, Issue 8, pp. 486-92, (2000) (PubMed).
: "Genomic organization and chromosomal localization of the human CUL2 gene and the role of von Hippel-Lindau tumor suppressor-binding protein (CUL2 and VBP1) mutation and loss in renal-cell carcinoma ..." dans: Genes, chromosomes & cancer, Vol. 26, Issue 1, pp. 20-8, (1999) (PubMed).
: "Human CUL-1, but not other cullin family members, selectively interacts with SKP1 to form a complex with SKP2 and cyclin A." dans: Cell growth & differentiation : the molecular biology journal of the American Association for Cancer Research, Vol. 9, Issue 6, pp. 435-49, (1998) (PubMed).
: "The von Hippel-Lindau tumor-suppressor gene product forms a stable complex with human CUL-2, a member of the Cdc53 family of proteins." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 94, Issue 6, pp. 2156-61, (1997) (PubMed).
: "cul-1 is required for cell cycle exit in C. elegans and identifies a novel gene family." dans: Cell, Vol. 85, Issue 6, pp. 829-39, (1996) (PubMed).
Synonymes et noms alternatifs relatifs à Cullin 2
cullin 2 (cul2), cullin 2 (CUL2), cullin-2 (PTRG_05231), putative cullin-2 (cul-2) (Smp_079740), cullin-2 (LOC100550749), cullin 2 (Cul2), cullin 2 L homeolog (cul2.L), Cullin-2 (cul-2), 1300003D18Rik, 4932411N15Rik, AI327301, ATCUL2, cul2, Cullin-2, cullin-2, cullin 2, F22D16.2, F22D16_2, fj48a06, LOC100221330, mKIAA4106, wu:fj48a06Protein level used designations for Cullin 2
- Cullin-2
- CUL-2
- cullin-2
- cullin-2 (cul-2)
- cullin 2
- cullin-2-like
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