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CYP2C8 Produits

(Cytochrome P450, Family 2, Subfamily C, Polypeptide 8 (CYP2C8))

Catégories

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by phenobarbital. The enzyme is known to metabolize many xenobiotics, including the anticonvulsive drug mephenytoin, benzo(a)pyrene, 7-ethyoxycoumarin, and the anti-cancer drug taxol. This gene is located within a cluster of cytochrome P450 genes on chromosome 10q24. Several transcript variants encoding a few different isoforms have been found for this gene. [provided by RefSeq, Nov 2010].

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Catégories CYP2C8 en vedette

CYP2C8 Anticorps

High quality antibodies with extensive validation data.

CYP2C8 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

CYP2C8 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB
Validations
  • (2)
N° du produit ABIN514832
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (2)
N° du produit ABIN947772
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human, Mouse
Application ELISA, WB, IHC
Validations
  • (2)
N° du produit ABIN6258063
Quantité 100 μL
Fiche technique Fiche technique

CYP2C8 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
N° du produit ABIN6214689
Quantité 96 tests
Fiche technique Fiche technique

CYP2C8 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7122581
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1350971
Quantité 25 μg
Fiche technique Fiche technique
Reactivity Human
Source Tobacco (Nicotiana tabacum)
Validations
N° du produit ABIN3078039
Quantité 1 mg
Fiche technique Fiche technique

Dernières publications sur nos produits CYP2C8

Thomas, Winter, Klumpp, Turpeinen, Klein, Schwab, Zanger: "Peroxisome proliferator-activated receptor alpha, PPARα, directly regulates transcription of cytochrome P450 CYP2C8." dans: Frontiers in pharmacology, Vol. 6, pp. 261, (2015) (PubMed).

Leskelä, Jara, Leandro-García, Martínez, García-Donas, Hernando, Hurtado, Vicario, Montero-Conde, Landa, López-Jiménez, Cascón, Milne, Robledo, Rodríguez-Antona: "Polymorphisms in cytochromes P450 2C8 and 3A5 are associated with paclitaxel neurotoxicity." dans: The pharmacogenomics journal, Vol. 11, Issue 2, pp. 121-9, (2011) (PubMed).

Pavlov, Ilatovskaya, Levchenko, Mattson, Roman, Staruschenko: "Effects of cytochrome P-450 metabolites of arachidonic acid on the epithelial sodium channel (ENaC)." dans: American journal of physiology. Renal physiology, Vol. 301, Issue 3, pp. F672-81, (2011) (PubMed).

Werck-Reichhart, Feyereisen: "Cytochromes P450: a success story." dans: Genome biology, Vol. 1, Issue 6, pp. REVIEWS3003, (2001) (PubMed).

Synonymes et noms alternatifs relatifs à CYP2C8

cytochrome P450 family 2 subfamily C member 8 (CYP2C8), Cytochrome P450 2C8 (CTN_0597), cytochrome P450, family 2, subfamily C, polypeptide 8 (CYP2C8), cytochrome P450 family 2 subfamily C member 8 S homeolog (cyp2c8.1.S), cytochrome P450 family 2 subfamily C member 8 (cyp2c8.1), CPC8, cpc8, cyp2c8, CYP2C74, CYPIIC8, cypiic8, MP-12/MP-20, mp-12/mp-20

Protein level used designations for CYP2C8

  • P450 form 1
  • cytochrome P450 2C8
  • cytochrome P450 IIC2
  • cytochrome P450 MP-12
  • cytochrome P450 MP-20
  • cytochrome P450 form 1
  • cytochrome P450, subfamily IIC (mephenytoin 4-hydroxylase), polypeptide 8
  • flavoprotein-linked monooxygenase
  • microsomal monooxygenase
  • s-mephenytoin 4-hydroxylase
  • xenobiotic monooxygenase
  • Cytochrome P450 2C8
  • cytochrome P450 CYP2C74
  • cytochrome P450, family 2, subfamily C, polypeptide 8
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