CYP3A4 Produits
(Cytochrome P450, Family 3, Subfamily A, Polypeptide 4 (CYP3A4))
Catégories
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This enzyme has a low level of testosterone hydroxylase activity. Although it bears homology to some drug-metabolizing cytochrome P450s, it is unknown whether the enzyme is also involved in xenobiotic metabolism. This gene is part of a cluster of cytochrome P450 genes on chromosome 7q21.1. Alternate splicing of this gene results in three transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].
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Catégories CYP3A4 en vedette
CYP3A4 Anticorps
High quality antibodies with extensive validation data.
CYP3A4 Kits ELISA
Reliable ELISA kits for a wide range of species.
CYP3A4 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
CYP3A4 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS, ICC
Validations
- (2)
- (7)
N° du produit
ABIN969512
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, FACS, IF (p), IHC (p), ICC, IF (cc), IHC (fro)
Validations
- (1)
- (4)
N° du produit
ABIN733793
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (3)
- (4)
N° du produit
ABIN514838
Quantité
50 μg
Fiche technique
Fiche technique
CYP3A4 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
- (1)
N° du produit
ABIN6955259
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966251
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955258
Quantité
96 tests
Fiche technique
Fiche technique
CYP3A4 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122583
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1350990
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1350988
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits CYP3A4
: "PAMAM dendrimer grafted cellulose paper scaffolds as a novel in vitro 3D liver model for drug screening applications." dans: Colloids and surfaces. B, Biointerfaces, Vol. 172, pp. 346-354, (2019) (PubMed).: "Sesquiterpenes Are Agonists of the Pregnane X Receptor but Do Not Induce the Expression of Phase I Drug-Metabolizing Enzymes in the Human Liver." dans: International journal of molecular sciences, Vol. 20, Issue 18, (2019) (PubMed).
: "Liver lobe and strain differences in the activity of murine cytochrome P450 enzymes." dans: Toxicology, Vol. 404-405, pp. 76-85, (2019) (PubMed).
: "Comparative pharmacokinetics and safety assessment of transdermal berberine and dihydroberberine." dans: PLoS ONE, Vol. 13, Issue 3, pp. e0194979, (2018) (PubMed).
: "Oroxylin A activates PKM1/HNF4 alpha to induce hepatoma differentiation and block cancer progression." dans: Cell death & disease, Vol. 8, Issue 7, pp. e2944, (2018) (PubMed).
: "Functional expression and comparative characterization of four feline P450 cytochromes using fluorescent substrates." dans: Xenobiotica; the fate of foreign compounds in biological systems, Vol. 47, Issue 11, pp. 951-961, (2017) (PubMed).
: "Transport and uptake of clausenamide enantiomers in CYP3A4-transfected Caco-2 cells: An insight into the efflux-metabolism alliance." dans: Biochemical pharmacology, Vol. 98, Issue 1, pp. 224-30, (2015) (PubMed).
: "Ascorbic acid reverses the prolonged anesthetic action of pentobarbital in Akr1a-knockout mice." dans: Life sciences, Vol. 95, Issue 1, pp. 1-8, (2014) (PubMed).
: "Dermal xenobiotic metabolism: a comparison between native human skin, four in vitro skin test systems and a liver system." dans: Skin pharmacology and physiology, Vol. 27, Issue 5, pp. 263-75, (2014) (PubMed).
: "Identification and characterization of a defective CYP3A4 genotype in a kidney transplant patient with severely diminished tacrolimus clearance." dans: Clinical pharmacology and therapeutics, Vol. 95, Issue 4, pp. 416-22, (2014) (PubMed).
Synonymes et noms alternatifs relatifs à CYP3A4
cytochrome P450 family 3 subfamily A member 4 (CYP3A4), cytochrome P450 family 3 subfamily A member 43 (CYP3A43), cytochrome P450 3A4 (PTRG_01782), cytochrome P450 3A4 (PTRG_06060), cytochrome P450 family 3 subfamily A member 4 (cyp3a4), cytochrome P450, subfamily IIIA, polypeptide 4 (CYP3A4), cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4 (CYP3A4), cytochrome P450, family 3, subfamily A, polypeptide 4 (CYP3A4), CP33, CP34, CYP3A, CYP3A3, CYP3A4, CYP3A12, CYP3A21, CYP3A80, CYPIIIA3, CYPIIIA4, CYPIIIA21, HLP, MGC108372, NF-25, P450C3, P450PCN1Protein level used designations for CYP3A4
- 1,8-cineole 2-exo-monooxygenase
- P450-III, steroid inducible
- albendazole monooxygenase
- albendazole sulfoxidase
- cytochrome P450 3A3
- cytochrome P450 3A4
- cytochrome P450 HLp
- cytochrome P450 NF-25
- cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 3
- cytochrome P450, subfamily IIIA (niphedipine oxidase), polypeptide 4
- cytochrome P450-PCN1
- glucocorticoid-inducible P450
- nifedipine oxidase
- quinine 3-monooxygenase
- taurochenodeoxycholate 6-alpha-hydroxylase
- cytochrome P450 3A43
- cytochrome P450, subfamily IIIA, polypeptide 43
- cytochrome P450, family 3, subfamily A, polypeptide 4
- cytochrome P450 3A80
- Cytochrome P450 CM3A-10
- cytochrome P450 3A21
- cytochrome P450 CYP3A12
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