DAB2 Produits
(Disabled Homolog 2, Mitogen-Responsive phosphoprotein (Drosophila) (DAB2))
Catégories
This gene encodes a mitogen-responsive phosphoprotein. It is expressed in normal ovarian epithelial cells, but is down-regulated or absent from ovarian carcinoma cell lines, suggesting its role as a tumor suppressor. This protein binds to the SH3 domains of GRB2, an adaptor protein that couples tyrosine kinase receptors to SOS (a guanine nucleotide exchange factor for Ras), via its C-terminal proline-rich sequences, and may thus modulate growth factor/Ras pathways by competing with SOS for binding to GRB2. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2011].
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Catégories DAB2 en vedette
DAB2 Anticorps
High quality antibodies with extensive validation data.
DAB2 Kits ELISA
Reliable ELISA kits for a wide range of species.
DAB2 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
DAB2 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (4)
N° du produit
ABIN514859
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, FACS, IHC (p)
Validations
- (3)
N° du produit
ABIN652936
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human, Rat
Application
WB, ELISA, IF (cc), IF (p), FACS, IHC (p), IHC (fro)
Validations
- (2)
N° du produit
ABIN760961
Quantité
100 μL
Fiche technique
Fiche technique
DAB2 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966388
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4882557
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1129853
Quantité
96 tests
Fiche technique
Fiche technique
DAB2 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122677
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1351061
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1351065
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits DAB2
: "Cathepsin-B-mediated cleavage of Disabled-2 regulates TGF-β-induced autophagy." dans: Nature cell biology, Vol. 18, Issue 8, pp. 851-63, (2016) (PubMed).: "The histone demethylase Kdm3a is essential to progression through differentiation." dans: Nucleic acids research, Vol. 40, Issue 15, pp. 7219-32, (2012) (PubMed).
: "Disabled-2 protein facilitates assembly polypeptide-2-independent recruitment of cystic fibrosis transmembrane conductance regulator to endocytic vesicles in polarized human airway epithelial cells." dans: The Journal of biological chemistry, Vol. 287, Issue 18, pp. 15087-99, (2012) (PubMed).
: "Alpha-AP-2 directs myosin VI-dependent endocytosis of cystic fibrosis transmembrane conductance regulator chloride channels in the intestine." dans: The Journal of biological chemistry, Vol. 285, Issue 22, pp. 17177-87, (2010) (PubMed).
: "TGF-beta-mediated phosphorylation of hnRNP E1 induces EMT via transcript-selective translational induction of Dab2 and ILEI." dans: Nature cell biology, Vol. 12, Issue 3, pp. 286-93, (2010) (PubMed).
: "Homozygous loss of BHD causes early embryonic lethality and kidney tumor development with activation of mTORC1 and mTORC2." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 44, pp. 18722-7, (2009) (PubMed).
: "Cutting edge: Dab2 is a FOXP3 target gene required for regulatory T cell function." dans: Journal of immunology (Baltimore, Md. : 1950), Vol. 183, Issue 7, pp. 4192-6, (2009) (PubMed).
: "Dab2 stabilizes Axin and attenuates Wnt/beta-catenin signaling by preventing protein phosphatase 1 (PP1)-Axin interactions." dans: Oncogene, Vol. 28, Issue 33, pp. 2999-3007, (2009) (PubMed).
: "Disabled-2 exhibits the properties of a cargo-selective endocytic clathrin adaptor." dans: The EMBO journal, Vol. 21, Issue 18, pp. 4915-26, (2002) (PubMed).
: "The adaptor molecule Disabled-2 links the transforming growth factor beta receptors to the Smad pathway." dans: The EMBO journal, Vol. 20, Issue 11, pp. 2789-801, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à DAB2
DAB2, clathrin adaptor protein (DAB2), disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila) (dab2), Dab, mitogen-responsive phosphoprotein, homolog 2 (dab2), DAB2, clathrin adaptor protein (Dab2), disabled 2, mitogen-responsive phosphoprotein (Dab2), 5730435J12Rik, AA960054, AI957090, D15Wsu122e, D630005B22Rik, DOC-2, Doc-2, DOC2, Doc2, p96Protein level used designations for DAB2
- disabled homolog 2, mitogen-responsive phosphoprotein (Drosophila)
- disabled homolog 2
- disabled homolog 2, mitogen-responsive phosphoprotein
- disabled homolog 2-like
- differentially-expressed protein 2
- mitogen-responsive phosphoprotein
- C9
- DOC-2 p82 isoform
- disabled homolog 2 mitogen-responsive phosphoprotein
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