In mammals, the Y chromosome directs the development of the testes and plays an important role in spermatogenesis. A high percentage of infertile men have deletions that map to regions of the Y chromosome. The DAZ (deleted in azoospermia) gene cluster maps to the AZFc region of the Y chromosome and is deleted in many azoospermic and severely oligospermic men. It is thought that the DAZ gene cluster arose from the transposition, amplification, and pruning of the ancestral autosomal gene DAZL also involved in germ cell development and gametogenesis. This gene encodes a RNA-binding protein with two RNP motifs that was originally identified by its interaction with the infertility factors DAZ and DAZL. Two isoforms are encoded by transcript variants of this gene. [provided by RefSeq, Jul 2008].
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Hayakawa, Fujikane, Ito, Matsumoto, Nakayama, Sekiguchi: "Human proteins that specifically bind to 8-oxoguanine-containing RNA and their responses to oxidative stress." dans: Biochemical and biophysical research communications, Vol. 403, Issue 2, pp. 220-4, (2010) (PubMed).
Sutherland, Sobinoff, Fraser, Redgrove, Siddall, Koopman, Hime, McLaughlin: "RNA binding protein Musashi-2 regulates PIWIL1 and TBX1 in mouse spermatogenesis." dans: Journal of cellular physiology, Vol. 233, Issue 4, pp. 3262-3273 (PubMed).
Synonymes et noms alternatifs relatifs à DAZAP1
DAZ associated protein 1 (dazap1), DAZ associated protein 1 (DAZAP1), DAZ associated protein 1 (Dazap1), DAZ associated protein 1 L homeolog (dazap1.L), 2410042M16Rik, DAZAP1, MGC89358, mPrrp