Deoxyuridine Triphosphatase Produits
(Deoxyuridine Triphosphatase (DUT))
Catégories
This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous, homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication, and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA, which induces extensive excision repair mediated by uracil glycosylase. This repair process, resulting in the removal and reincorporation of dUTP, is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19. [provided by RefSeq, Jul 2008].
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Catégories Deoxyuridine Triphosphatase en vedette
Deoxyuridine Triphosphatase Anticorps
High quality antibodies with extensive validation data.
Deoxyuridine Triphosphatase Kits ELISA
Reliable ELISA kits for a wide range of species.
Deoxyuridine Triphosphatase Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Deoxyuridine Triphosphatase recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p), IF
Validations
- (1)
- (5)
N° du produit
ABIN560672
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN7260715
Quantité
200 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN7266736
Quantité
100 μL
Fiche technique
Fiche technique
Deoxyuridine Triphosphatase recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966332
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Validations
N° du produit
ABIN1129512
Quantité
96 tests
Fiche technique
Fiche technique
Deoxyuridine Triphosphatase recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122640
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122639
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1352151
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Deoxyuridine Triphosphatase
: "The 1,2-Diaminocyclohexane Carrier Ligand in Oxaliplatin Induces p53-Dependent Transcriptional Repression of Factors Involved in Thymidylate Biosynthesis." dans: Molecular cancer therapeutics, Vol. 14, Issue 10, pp. 2332-42, (2015) (PubMed).: "Kinetic mechanism of human dUTPase, an essential nucleotide pyrophosphatase enzyme." dans: The Journal of biological chemistry, Vol. 282, Issue 46, pp. 33572-82, (2007) (PubMed).
: "Modulation of human dUTPase using small interfering RNA." dans: Biochemical and biophysical research communications, Vol. 327, Issue 1, pp. 306-10, (2005) (PubMed).
: "The role of dUTPase and uracil-DNA repair in cancer chemotherapy." dans: Current protein & peptide science, Vol. 2, Issue 4, pp. 361-70, (2002) (PubMed).
Synonymes et noms alternatifs relatifs à Deoxyuridine Triphosphatase
deoxyuridine triphosphatase (DUT), Deoxyuridine triphosphatase (dUTPase), deoxyuridine triphosphatase (P18), dUTPase; ORF54; similar to EBV BLLF3, CMV UL72, HSV UL50 (AlHV1gp51), deoxyuridine triphosphatase (UL50), deoxyuridine triphosphatase (HVT058), involved in nucleotide metabolism (UL50), deoxyuridine triphosphatase (ORF9), deoxyuridine triphosphatase (ORF8), tegument protein (U45), dUTPase (GAMMAHV.ORF54), deoxyuridine triphosphatase (Tc00.1047053509151.130), deoxyuridine triphosphatase (Tc00.1047053508175.160), deoxyuridine triphosphatase (Tb927.7.5160), deoxyuridine triphosphatase L homeolog (dut.L), deoxyuridine triphosphatase (Dut), 5031412I06Rik, 5133400F09Rik, anon-SAGE:Wang-077, BcDNA:LD08534, CG4584, D2Bwg0749e, Dmel\\CG4584, Dutp, dUTPase, dutpase, LD08534, PIP4, Tb07.27E10.390, UTPaseProtein level used designations for Deoxyuridine Triphosphatase
- dUTP pyrophosphatase
- CG4584-PA
- CG4584-PB
- CG4584-PC
- CG4584-PD
- anon-SAGE:Wang-077
- dUTPase-PA
- dUTPase-PB
- dUTPase-PC
- dUTPase-PD
- deoxyuridine triphosphatase
- deoxyuridine 5'-triphosphate nucleotidohydrolase
- deoxyuridine triphosphatase, dUTPase, P18
- dUTP nucleotidohydrolase
- deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial
- PPAR-interacting protein 4
- dUTPase
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