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DIO2 Produits

(Deiodinase, Iodothyronine, Type II (DIO2))
The protein encoded by this gene belongs to the iodothyronine deiodinase family. It activates thyroid hormone by converting the prohormone thyroxine (T4) by outer ring deiodination (ORD) to bioactive 3,3',5-triiodothyronine (T3). It is highly expressed in the thyroid, and may contribute significantly to the relative increase in thyroidal T3 production in patients with Graves disease and thyroid adenomas. This protein contains selenocysteine (Sec) residues encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Catégories DIO2 en vedette

DIO2 Anticorps

High quality antibodies with extensive validation data.

DIO2 Kits ELISA

Reliable ELISA kits for a wide range of species.

DIO2 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

DIO2 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse
Application WB, IHC (p), FACS
Validations
  • (5)
N° du produit ABIN652664
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application ELISA, IHC, FACS, IF
Validations
  • (1)
  • (3)
N° du produit ABIN190862
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7173972
Quantité 100 μg
Fiche technique Fiche technique

DIO2 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Competition ELISA
Validations
  • (1)
N° du produit ABIN6966307
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955327
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955328
Quantité 96 tests
Fiche technique Fiche technique

DIO2 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1351608
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7413544
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7413547
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits DIO2

Zuo, Liu, Gao, Yin, Wang, Hou, Fu, Liu, Wang, Xu, Pi: "Prolonged inorganic arsenic exposure via drinking water impairs brown adipose tissue function in mice." dans: The Science of the total environment, Vol. 668, pp. 310-317, (2019) (PubMed).

Ma, Brouwer, Wesseling, Raj, van der Want, Boddeke, Balasubramaniyan, Copray: "Multipotent stem cell factor UGS148 is a marker for tanycytes in the adult hypothalamus." dans: Molecular and cellular neurosciences, Vol. 65, pp. 21-30, (2015) (PubMed).

Kishida, Ejima, Yamamoto, Tanaka, Yamamoto, Mazda: "Reprogrammed Functional Brown Adipocytes Ameliorate Insulin Resistance and Dyslipidemia in Diet-Induced Obesity and Type 2 Diabetes." dans: Stem cell reports, Vol. 5, Issue 4, pp. 569-81, (2015) (PubMed).

Vose, Vinukonda, Jo, Miry, Diamond, Korumilli, Arshad, Zia, Hu, Kayton, La Gamma, Bansal, Bianco, Ballabh: "Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 44, pp. 17232-46, (2013) (PubMed).

Langford, Baron, Joy, Del Valle, Shack: "Contributions of HIV infection in the hypothalamus and substance abuse/use to HPT dysregulation." dans: Psychoneuroendocrinology, Vol. 36, Issue 5, pp. 710-9, (2011) (PubMed).

Gumieniak, Perlstein, Williams, Hopkins, Brown, Raby, Williams: "Ala92 type 2 deiodinase allele increases risk for the development of hypertension." dans: Hypertension, Vol. 49, Issue 3, pp. 461-6, (2007) (PubMed).

Synonymes et noms alternatifs relatifs à DIO2

iodothyronine deiodinase 2 (DIO2), deiodinase, iodothyronine, type II (Dio2), iodothyronine deiodinase 2 (dio2), deiodinase, iodothyronine, type II (dio2), deiodinase, iodothyronine, type 2 L homeolog (dio2.L), deiodinase, iodothyronine, type 2 (dio2), iodothyronine deiodinase 2 (Dio2), type II iodothyronine deiodinase (LOC100861220), 5DII, 5dii, AI324267, cb684, D2, Deio2, DIO2, dio2-A, DIOII, SelY, sely, TXDI2, txdi2

Protein level used designations for DIO2

  • thyroxine deiodinase, type II
  • type 2 DI
  • type 2 iodothyronine deiodinase
  • type II iodothyronine deiodinase
  • type-II 5'-deiodinase
  • type-II 5'deiodinase
  • iodothyronine type II deiodinase
  • type-II 5' deiodinase
  • deiodinase, iodothyronine, type 2
  • D2
  • 5DII
  • DIOII
  • deiodinase, iodothyronine, type II
  • deiodinase 2
  • type 2 deiodinase
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