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DIO3 Produits

(Deiodinase, Iodothyronine, Type III (DIO3))
The protein encoded by this intronless gene belongs to the iodothyronine deiodinase family. It catalyzes the inactivation of thyroid hormone by inner ring deiodination of the prohormone thyroxine (T4) and the bioactive hormone 3,3',5-triiodothyronine (T3) to inactive metabolites, 3,3',5'-triiodothyronine (RT3) and 3,3'-diiodothyronine (T2), respectively. This enzyme is highly expressed in the pregnant uterus, placenta, fetal and neonatal tissues, suggesting that it plays an essential role in the regulation of thyroid hormone inactivation during embryological development. This protein contains a selenocysteine (Sec) residue, which is essential for efficient enzyme activity. The selenocysteine is encoded by the UGA codon, which normally signals translation termination. The 3' UTR of Sec-containing genes have a common stem-loop structure, the sec insertion sequence (SECIS), which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. [provided by RefSeq, Jul 2008].

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Catégories DIO3 en vedette

DIO3 Anticorps

High quality antibodies with extensive validation data.

DIO3 Kits ELISA

Reliable ELISA kits for a wide range of species.

DIO3 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

DIO3 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Application WB, IHC, IP, ICC
Validations
  • (5)
N° du produit ABIN7436198
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Rat
Application WB, IHC, IHC (p)
Validations
  • (4)
N° du produit ABIN653482
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, ELISA, IHC (p)
Validations
  • (3)
N° du produit ABIN750883
Quantité 100 μL
Fiche technique Fiche technique

DIO3 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6966309
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6966308
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6955331
Quantité 96 tests
Fiche technique Fiche technique

DIO3 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1351611
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1777658
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Mouse
Source Escherichia coli (E. coli)
Validations
N° du produit ABIN7398734
Quantité 100 μg
Fiche technique Fiche technique

Dernières publications sur nos produits DIO3

Calonne, Isacco, Miles-Chan, Arsenijevic, Montani, Guillet, Boirie, Dulloo: "Reduced Skeletal Muscle Protein Turnover and Thyroid Hormone Metabolism in Adaptive Thermogenesis That Facilitates Body Fat Recovery During Weight Regain." dans: Frontiers in endocrinology, Vol. 10, pp. 119, (2019) (PubMed).

Benedetti, Lavecchia, Locatelli, Brizi, Corna, Todeschini, Novelli, Benigni, Zoja, Remuzzi, Xinaris: "Alteration of thyroid hormone signaling triggers the diabetes-induced pathological growth, remodeling, and dedifferentiation of podocytes." dans: JCI insight, Vol. 4, Issue 18, (2019) (PubMed).

Pörings, Lowin, Dufner, Grifka, Straub: "A thyroid hormone network exists in synovial fibroblasts of rheumatoid arthritis and osteoarthritis patients." dans: Scientific reports, Vol. 9, Issue 1, pp. 13235, (2019) (PubMed).

Yamauchi, Sakane, Yamashita, Hirota, Ueda, Kanai, Yamashita, Kondo, Fujii, Taura, Sone, Yasoda, Inagaki: "Effects of growth hormone on thyroid function are mediated by type 2 iodothyronine deiodinase in humans." dans: Endocrine, Vol. 59, Issue 2, pp. 353-363, (2018) (PubMed).

De Andrade, Neff, Strosova, Arsenijevic, Patthey-Vuadens, Scapozza, Montani, Ruegg, Dulloo, Dorchies: "Caloric restriction induces energy-sparing alterations in skeletal muscle contraction, fiber composition and local thyroid hormone metabolism that persist during catch-up fat upon refeeding." dans: Frontiers in physiology, Vol. 6, pp. 254, (2015) (PubMed).

Maynard, Marino-Enriquez, Fletcher, Dorfman, Raut, Yassa, Guo, Wang, Dorfman, Feldman, Frates, Song, Jugo, Taguchi, Hershman, Larsen, Huang: "Thyroid hormone inactivation in gastrointestinal stromal tumors." dans: The New England journal of medicine, Vol. 370, Issue 14, pp. 1327-34, (2014) (PubMed).

Medina, Fonesca, Molina, Fachado, Castillo, Dong, Soares, Hernández, Caicedo, Bianco: "Maternal inheritance of an inactive type III deiodinase gene allele affects mouse pancreatic β-cells and disrupts glucose homeostasis." dans: Endocrinology, Vol. 155, Issue 8, pp. 3160-71, (2014) (PubMed).

Castroneves, Jugo, Maynard, Lee, Wassner, Dorfman, Bronson, Ukomadu, Agoston, Ding, Luongo, Guo, Song, Demchev, Lee, Feldman, Vella, Peake, Hartigan, Kellogg, Desai, Salvatore, Dentice, Huang: "Mice with hepatocyte-specific deficiency of type 3 deiodinase have intact liver regeneration and accelerated recovery from nonthyroidal illness after toxin-induced hepatonecrosis." dans: Endocrinology, Vol. 155, Issue 10, pp. 4061-8, (2014) (PubMed).

Dudek, Suter, Darras, Marczylo, Gant: "Decreased translation of Dio3 mRNA is associated with drug-induced hepatotoxicity." dans: The Biochemical journal, Vol. 453, Issue 1, pp. 71-82, (2013) (PubMed).

Vose, Vinukonda, Jo, Miry, Diamond, Korumilli, Arshad, Zia, Hu, Kayton, La Gamma, Bansal, Bianco, Ballabh: "Treatment with thyroxine restores myelination and clinical recovery after intraventricular hemorrhage." dans: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 33, Issue 44, pp. 17232-46, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à DIO3

iodothyronine deiodinase 3 (DIO3), deiodinase, iodothyronine, type 3 (dio3), deiodinase, iodothyronine, type III (dio3), deiodinase, iodothyronine type III (Dio3), deiodinase, iodothyronine, type 3 L homeolog (dio3.L), iodothyronine deiodinase 3 (Dio3), 5DIII, D3, DIOIII, dioiii, itdi3, txdi3, TXDI3, XL-15

Protein level used designations for DIO3

  • type III iodothyronine deiodinase
  • Type 3 DI
  • Type-III 5'-deiodinase
  • type 3 iodothyronine deiodinase
  • deiodinase, iodothyronine, type III
  • gene 15
  • type 3 deiodinase
  • iodothyronine 5-deiodinase type III
  • 5DIII
  • DIOIII
  • type 3 DI
  • type-III 5'-deiodinase
  • deiodinase, iodothyronine, type 3
  • iodothyronine deiodinase, placental type
  • thyroxine deiodinase type III (selenoprotein)
  • type 3 iodothyronine selenodeiodinase
  • type-III 5' deiodinase
  • iodothyronine deiodinase type III
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