DIS3 Produits
(Exosome Complex Exonuclease RRP44 (DIS3))
Catégories
Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. DIS3 has both 3'-5' exonuclease and endonuclease activities (By similarity).
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Catégories DIS3 en vedette
DIS3 Anticorps
High quality antibodies with extensive validation data.
DIS3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
DIS3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (1)
- (2)
N° du produit
ABIN524835
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (3)
N° du produit
ABIN524836
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (2)
N° du produit
ABIN654155
Quantité
400 μL
Fiche technique
Fiche technique
DIS3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6228991
Quantité
96 tests
Fiche technique
Fiche technique
DIS3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1351629
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3095104
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3137036
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits DIS3
: "Global analysis of the nuclear processing of transcripts with unspliced U12-type introns by the exosome." dans: Nucleic acids research, Vol. 42, Issue 11, pp. 7358-69, (2014) (PubMed).: "Multiple myeloma-associated hDIS3 mutations cause perturbations in cellular RNA metabolism and suggest hDIS3 PIN domain as a potential drug target." dans: Nucleic acids research, Vol. 42, Issue 2, pp. 1270-90, (2014) (PubMed).
: "Mammalian 5'-capped microRNA precursors that generate a single microRNA." dans: Cell, Vol. 155, Issue 7, pp. 1568-80, (2013) (PubMed).
: "The fission yeast dis3+ gene encodes a 110-kDa essential protein implicated in mitotic control." dans: Molecular and cellular biology, Vol. 11, Issue 12, pp. 5839-47, (1991) (PubMed).
Synonymes et noms alternatifs relatifs à DIS3
DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (DIS3), DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (Dis3), DIS3 exosome endoribonuclease and 3'-5' exoribonuclease (dis3), DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease (dis3.L), 2810028N01Rik, bA555G22.1, DIS3, dis3, dis3p, EXOSC11, KIAA1008, RGD1304646, RP11-342J4.3, RRP44, wu:fb08g12Protein level used designations for DIS3
- 2810028N01Rik
- exosome complex exonuclease RRP44
- exosome component 11
- mitotic control protein dis3 homolog
- protein DIS3 homolog
- ribosomal RNA-processing protein 44
- DIS3 mitotic control homolog (S. cerevisiae)
- DIS3 mitotic control homolog
- DIS3 exosome endoribonuclease and 3'-5' exoribonuclease
- DIS3 homolog, exosome endoribonuclease and 3'-5' exoribonuclease
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