Doublecortin Produits
(Doublecortin (DCX))
Catégories
This gene encodes a member of the doublecortin family. The protein encoded by this gene is a cytoplasmic protein and contains two doublecortin domains, which bind microtubules. In the developing cortex, cortical neurons must migrate over long distances to reach the site of their final differentiation. The encoded protein appears to direct neuronal migration by regulating the organization and stability of microtubules. In addition, the encoded protein interacts with LIS1, the regulatory gamma subunit of platelet activating factor acetylhydrolase, and this interaction is important to proper microtubule function in the developing cortex. Mutations in this gene cause abnormal migration of neurons during development and disrupt the layering of the cortex, leading to epilepsy, mental retardation, subcortical band heterotopia ('double cortex' syndrome) in females and lissencephaly ('smooth brain' syndrome) in males. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2010].
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Catégories Doublecortin en vedette
Doublecortin Anticorps
High quality antibodies with extensive validation data.
Doublecortin Kits ELISA
Reliable ELISA kits for a wide range of species.
Doublecortin Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Doublecortin recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, ICC, FACS
Validations
- (1)
- (7)
N° du produit
ABIN969513
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, ELISA, IHC, IF
Validations
- (5)
N° du produit
ABIN625829
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC, FACS, IF/ICC
Validations
- (8)
N° du produit
ABIN1844030
Quantité
100 μL
Fiche technique
Fiche technique
Doublecortin recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955452
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955453
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955454
Quantité
96 tests
Fiche technique
Fiche technique
Doublecortin recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
- (1)
N° du produit
ABIN1351244
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122702
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Rat
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7396373
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Doublecortin
: "Regulation of the p75 neurotrophin receptor attenuates neuroinflammation and stimulates hippocampal neurogenesis in experimental Streptococcus pneumoniae meningitis." dans: Journal of neuroinflammation, Vol. 18, Issue 1, pp. 253, (2022) (PubMed).: "LC-MS/MS identification of doublecortin as abundant beta cell-selective protein discharged by damaged beta cells in vitro." dans: Journal of proteomics, Vol. 80, pp. 268-80, (2013) (PubMed).
: "Properties of doublecortin-(DCX)-expressing cells in the piriform cortex compared to the neurogenic dentate gyrus of adult mice." dans: PLoS ONE, Vol. 6, Issue 10, pp. e25760, (2011) (PubMed).
: "Granulocyte colony-stimulating factor increases the therapeutic efficacy of bone marrow mononuclear cell transplantation in cerebral ischemia in mice." dans: BMC neuroscience, Vol. 12, pp. 61, (2011) (PubMed).
: "MiR-128 up-regulation inhibits Reelin and DCX expression and reduces neuroblastoma cell motility and invasiveness." dans: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 23, Issue 12, pp. 4276-87, (2009) (PubMed).
: "The location of DCX mutations predicts malformation severity in X-linked lissencephaly." dans: Neurogenetics, Vol. 9, Issue 4, pp. 277-85, (2008) (PubMed).
: "Doublecortin is expressed in articular chondrocytes." dans: Biochemical and biophysical research communications, Vol. 363, Issue 3, pp. 694-700, (2007) (PubMed).
: "Induction of neurogenesis in the neocortex of adult mice." dans: Nature, Vol. 405, Issue 6789, pp. 951-5, (2000) (PubMed).
: "A novel CNS gene required for neuronal migration and involved in X-linked subcortical laminar heterotopia and lissencephaly syndrome." dans: Cell, Vol. 92, Issue 1, pp. 51-61, (1998) (PubMed).
: "Doublecortin, a brain-specific gene mutated in human X-linked lissencephaly and double cortex syndrome, encodes a putative signaling protein." dans: Cell, Vol. 92, Issue 1, pp. 63-72, (1998) (PubMed).
Synonymes et noms alternatifs relatifs à Doublecortin
doublecortin (DCX), doublecortin (Dcx), 18C15.5, DBCN, Dbct, DC, DCX, LISX, SCLH, XLISProtein level used designations for Doublecortin
- doublecortex; lissencephaly, X-linked (doublecortin)
- doublecortin
- doublecortex
- doublin
- lis-X
- lissencephalin-X
- neuronal migration protein doublecortin
- lissencephaly, X-linked (doublecortin)
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