DRB1 Produits
(Dopamine Receptor Binding 1 (DRB1))
Catégories
HLA-DRB1 belongs to the HLA class II beta chain paralogs. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages). The beta chain is approximately 26-28 kDa. It is encoded by 6 exons. Exon one encodes the leader peptide\; exons 2 and 3 encode the two extracellular domains\; exon 4 encodes the transmembrane domain\; and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation. DRB1 is expressed at a level five times higher than its paralogs DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9. [provided by RefSeq, Jul 2008].
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DRB1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Dog, Human, Mouse, Rat
Application
WB
Validations
- (1)
N° du produit
ABIN629925
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB
Validations
- (1)
N° du produit
ABIN2776653
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Dog, Human, Mouse, Rat
Application
WB, ELISA
Validations
- (1)
N° du produit
ABIN2462346
Quantité
100 μL
Fiche technique
Fiche technique
Dernières publications sur nos produits DRB1
: "The RNA-binding motif 45 (RBM45) protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients." dans: Acta neuropathologica, Vol. 124, Issue 5, pp. 717-32, (2012) (PubMed).Synonymes et noms alternatifs relatifs à DRB1
dopamine receptor binding 1 (Drb1)
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