Dual Specificity Phosphatase 3 Produits
(Dual Specificity Phosphatase 3 (DUSP3))
Catégories
The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008].
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Catégories Dual Specificity Phosphatase 3 en vedette
Dual Specificity Phosphatase 3 Anticorps
High quality antibodies with extensive validation data.
Dual Specificity Phosphatase 3 Kits ELISA
Reliable ELISA kits for a wide range of species.
Dual Specificity Phosphatase 3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Dual Specificity Phosphatase 3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, ICC, IP
Validations
- (4)
N° du produit
ABIN7426586
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IHC (p)
Validations
- (1)
- (3)
N° du produit
ABIN392924
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF
Validations
- (4)
N° du produit
ABIN560661
Quantité
50 μg
Fiche technique
Fiche technique
Dual Specificity Phosphatase 3 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN5591980
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
N° du produit
ABIN4885040
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Semi-Quantitative Sandwich ELISA
Validations
N° du produit
ABIN6384474
Quantité
96 tests
Fiche technique
Fiche technique
Dual Specificity Phosphatase 3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122713
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN667577
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1352132
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Dual Specificity Phosphatase 3
: "Vaccinia H1-related phosphatase is a phosphatase of ErbB receptors and is down-regulated in non-small cell lung cancer." dans: The Journal of biological chemistry, Vol. 286, Issue 12, pp. 10177-84, (2011) (PubMed).: "Protein tyrosine phosphatases: structure-function relationships." dans: The FEBS journal, Vol. 275, Issue 5, pp. 867-82, (2008) (PubMed).
: "Tyrosine phosphorylation of VHR phosphatase by ZAP-70." dans: Nature immunology, Vol. 4, Issue 1, pp. 44-8, (2002) (PubMed).
: "Inhibitory role for dual specificity phosphatase VHR in T cell antigen receptor and CD28-induced Erk and Jnk activation." dans: The Journal of biological chemistry, Vol. 276, Issue 7, pp. 4766-71, (2001) (PubMed).
: "Crystal structure of the dual specificity protein phosphatase VHR." dans: Science (New York, N.Y.), Vol. 272, Issue 5266, pp. 1328-31, (1996) (PubMed).
: "Human dual specificity phosphatase VHR activates maturation promotion factor and triggers meiotic maturation in Xenopus oocytes." dans: The Journal of biological chemistry, Vol. 270, Issue 23, pp. 14229-34, (1995) (PubMed).
: "Expression cloning of a human dual-specificity phosphatase." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 24, pp. 12170-4, (1993) (PubMed).
Synonymes et noms alternatifs relatifs à Dual Specificity Phosphatase 3
dual specificity phosphatase 3 (DUSP3), dual specificity phosphatase 3b (dusp3b), dual specificity phosphatase 3 (Dusp3), dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related) (Dusp3), 2210015O03Rik, 5031436O03Rik, dusp3, RGD1560049, si:bz18k17.3, si:rp71-18k17.3, T-DSP11, VHRProtein level used designations for Dual Specificity Phosphatase 3
- dual specificity phosphatase 3 (vaccinia virus phosphatase VH1-related)
- dual specificity phosphatase 3
- dual specificity protein phosphatase 3
- dual specificity protein phosphatase VHR
- serine/threonine specific protein phosphatase
- vaccinia H1-related phosphatase
- vaccinia virus phosphatase VH1-related
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