Dystrophin Produits
(Dystrophin (DMD))
Catégories
The dystrophin gene is the largest gene found in nature, measuring 2.4 Mb. The gene was identified through a positional cloning approach, targeted at the isolation of the gene responsible for Duchenne (DMD) and Becker (BMD) Muscular Dystrophies. DMD is a recessive, fatal, X-linked disorder occurring at a frequency of about 1 in 3,500 new-born males. BMD is a milder allelic form. In general, DMD patients carry mutations which cause premature translation termination (nonsense or frame shift mutations), while in BMD patients dystrophin is reduced either in molecular weight (derived from in-frame deletions) or in expression level. The dystrophin gene is highly complex, containing at least eight independent, tissue-specific promoters and two polyA-addition sites. Furthermore, dystrophin RNA is differentially spliced, producing a range of different transcripts, encoding a large set of protein isoforms. Dystrophin (as encoded by the Dp427 transcripts) is a large, rod-like cytoskeletal protein which is found at the inner surface of muscle fibers. Dystrophin is part of the dystrophin-glycoprotein complex (DGC), which bridges the inner cytoskeleton (F-actin) and the extra-cellular matrix. [provided by RefSeq, Jul 2008].
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Catégories Dystrophin en vedette
Dystrophin Anticorps
High quality antibodies with extensive validation data.
Dystrophin Kits ELISA
Reliable ELISA kits for a wide range of species.
Dystrophin Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
Dystrophin recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (5)
N° du produit
ABIN1679546
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IHC, IF
Validations
- (4)
N° du produit
ABIN7008615
Quantité
60 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IP, ELISA
Validations
- (4)
N° du produit
ABIN515027
Quantité
100 μg
Fiche technique
Fiche technique
Dystrophin recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Rat
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966439
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6966438
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Sandwich ELISA
Validations
- (1)
N° du produit
ABIN6955484
Quantité
96 tests
Fiche technique
Fiche technique
Dystrophin recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1351717
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7420834
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
N° du produit
ABIN7394210
Quantité
100 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits Dystrophin
: "In vivo cerebellar circuit function is disrupted in an mdx mouse model of Duchenne muscular dystrophy." dans: Disease models & mechanisms, Vol. 13, Issue 2, (2019) (PubMed).: "Immunohistochemical study on dystrophin expression in CAD-related sudden cardiac death: a marker of early myocardial ischaemia." dans: International journal of legal medicine, Vol. 132, Issue 5, pp. 1333-1339, (2018) (PubMed).
: "Dipeptidyl Peptidase 4 Inhibition Alleviates Shortage of Circulating Glucagon-Like Peptide-1 in Heart Failure and Mitigates Myocardial Remodeling and Apoptosis via the Exchange Protein Directly ..." dans: Circulation. Heart failure, Vol. 9, Issue 1, pp. e002081, (2016) (PubMed).
: "Isolation and characterization of neural stem cells from dystrophic mdx mouse." dans: Experimental cell research, Vol. 343, Issue 2, pp. 190-207, (2016) (PubMed).
: "Evidence for the involvement of the CXCL12 system in the adaptation of skeletal muscles to physical exercise." dans: Cellular signalling, Vol. 28, Issue 9, pp. 1205-15, (2016) (PubMed).
: "A dipeptidyl peptidase-4 inhibitor ameliorates hypertensive cardiac remodeling via angiotensin-II/sodium-proton pump exchanger-1 axis." dans: Journal of molecular and cellular cardiology, Vol. 98, pp. 37-47, (2016) (PubMed).
: "Dystrophin and dysferlin double mutant mice: a novel model for rhabdomyosarcoma." dans: Cancer genetics, Vol. 205, Issue 5, pp. 232-41, (2012) (PubMed).
: "Monoclonal antibodies for dystrophin analysis. Epitope mapping and improved binding to SDS-treated muscle sections." dans: The Biochemical journal, Vol. 288 ( Pt 2), pp. 663-8, (1993) (PubMed).
: "A quantitative ELISA for dystrophin." dans: Journal of immunological methods, Vol. 161, Issue 1, pp. 23-8, (1993) (PubMed).
Synonymes et noms alternatifs relatifs à Dystrophin
dystrophin (DMD), dystrophin (LOC708073), dystrophin, gene 1 L homeolog (dmd.1.L), dystrophin (LOC465557), dystrophin, gene 1 (dmd.1), dystrophin (dmd), dystrophin, muscular dystrophy (Dmd), dystrophin (Dmd), Dystrophin (Dys), BMD, cb664, CG7240, CG7243, CG7344, CG17750, CG31175, CG34157, CMD3B, det, DKFZp459C1629, DKFZp468A1620, DLP, DLP1, DLP2, DLP3, DLP186, DMD, Dmd, dmd, DmDLP, dmDLP, dmDp186, DmDYS, dmDys, Dmel\\CG34157, DNADMD1, Dp71, Dp117, Dp186, Dp205, Dp427, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, DXSmh7, DXSmh9, dys, GI3046716, IDLP, im:6911785, mdx, MGC79631, MGC83347, pke, RATDMD, zfDYS, zgc:110165Protein level used designations for Dystrophin
- dystrophin (muscular dystrophy, Duchenne and Becker types)
- dystrophin
- Duchenne muscular dystrophy
- dystrophin isoform Dp116
- sap
- sapje
- dystrophin Dp71 isoform
- X-linked muscular dystrophy
- RNDNADMD1
- apodystrophin-3
- apodystrophin-I
- dystrophin transcript variant Dp71e
- dystrophin, muscular dystrophy
- CG34157-PA
- CG34157-PB
- CG34157-PC
- CG34157-PD
- CG34157-PE
- CG34157-PF
- CG34157-PG
- CG34157-PH
- CG34157-PI
- CG34157-PJ
- CG34157-PK
- CG34157-PL
- Dys-PA
- Dys-PB
- Dys-PC
- Dys-PD
- Dys-PE
- Dys-PF
- Dys-PG
- Dys-PH
- Dys-PI
- Dys-PJ
- Dys-PK
- Dys-PL
- Dystrophin-like protein 1
- Dystrophin-like protein 186
- Dystrophin-like protein 2
- Dystrophin-like protein 3
- detached
- dystrophin Dp186
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