EGLN3 Produits
(Egl-9 Family Hypoxia Inducible Factor 3 (EGLN3))
Catégories
Cellular oxygen sensor that catalyzes, under normoxic conditions, the post-translational formation of 4-hydroxyproline in hypoxia-inducible factor (HIF) alpha proteins. Hydroxylates a specific proline found in each of the oxygen-dependent degradation (ODD) domains (N-terminal, NODD, and C-terminal, CODD) of HIF1A. Also hydroxylates HIF2A. Has a preference for the CODD site for both HIF1A and HIF2A. Hydroxylation on the NODD site by EGLN3 appears to require prior hydroxylation on the CODD site. Hydroxylated HIFs are then targeted for proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Under hypoxic conditions, the hydroxylation reaction is attenuated allowing HIFs to escape degradation resulting in their translocation to the nucleus, heterodimerization with HIF1B, and increased expression of hypoxy-inducible genes. ELGN3 is the most important isozyme in limiting physiological activation of HIFs (particularly HIF2A) in hypoxia. Also hydroxylates PKM2 in hypoxia, limiting glycolysis. Under normoxia, hydroxylates and regulates the stability of ADRB2. Regulator of cardiomyocyte and neuronal apoptosis. In cardiomyocytes, inhibits the anti-apoptotic effect of BCL2 by disrupting the BAX-BCL2 complex. In neurones, has a NGF-induced proapoptotic effect, probably through regulating CASP3 activity. Also essential for hypoxic regulation of neutrophilic inflammation.
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Catégories EGLN3 en vedette
EGLN3 Anticorps
High quality antibodies with extensive validation data.
EGLN3 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
EGLN3 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, IHC, IF
Validations
- (6)
N° du produit
ABIN6139990
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, IF
Validations
- (3)
N° du produit
ABIN530188
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IHC
Validations
- (2)
N° du produit
ABIN7151448
Quantité
100 μL
Fiche technique
Fiche technique
EGLN3 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Escherichia coli (E. coli)
Validations
- (1)
N° du produit
ABIN7122748
Quantité
50 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1352451
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1352449
Quantité
10 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits EGLN3
: "RNA binding protein HuR regulates extracellular matrix gene expression and pH homeostasis independent of controlling HIF-1α signaling in nucleus pulposus cells." dans: Matrix biology : journal of the International Society for Matrix Biology, Vol. 77, pp. 23-40, (2019) (PubMed).: "Hypoxia-inducible factor (HIF)-prolyl hydroxylase 3 (PHD3) maintains high HIF2A mRNA levels in clear cell renal cell carcinoma." dans: The Journal of biological chemistry, Vol. 294, Issue 10, pp. 3760-3771, (2019) (PubMed).
: "Prolyl hydroxylase 3 stabilizes the p53 tumor suppressor by inhibiting the p53-MDM2 interaction in a hydroxylase-independent manner." dans: The Journal of biological chemistry, Vol. 294, Issue 25, pp. 9949-9958, (2019) (PubMed).
: "Regulation of Hypoxia-Inducible Factor 1α during Hypoxia by DAP5-Induced Translation of PHD2." dans: Molecular and cellular biology, Vol. 38, Issue 11, (2018) (PubMed).
: "The Factor Inhibiting HIF Asparaginyl Hydroxylase Regulates Oxidative Metabolism and Accelerates Metabolic Adaptation to Hypoxia." dans: Cell metabolism, Vol. 27, Issue 4, pp. 898-913.e7, (2018) (PubMed).
: "PHD3 Acts as Tumor Suppressor in Mouse Osteosarcoma and Influences Tumor Vascularization via PDGF-C Signaling." dans: Cancers, Vol. 10, Issue 12, (2018) (PubMed).
: "Intermittent hypoxia induces beneficial cardiovascular remodeling in left ventricular function of type 1 diabetic rat." dans: Anatolian journal of cardiology, Vol. 19, Issue 4, pp. 259-266, (2018) (PubMed).
: "Defective Mitochondrial Cardiolipin Remodeling Dampens HIF-1α Expression in Hypoxia." dans: Cell reports, Vol. 25, Issue 3, pp. 561-570.e6, (2018) (PubMed).
: "PHD3 regulates glucose metabolism by suppressing stress-induced signalling and optimising gluconeogenesis and insulin signalling in hepatocytes." dans: Scientific reports, Vol. 8, Issue 1, pp. 14290, (2018) (PubMed).
: "Che-1 sustains hypoxic response of colorectal cancer cells by affecting Hif-1α stabilization." dans: Journal of experimental & clinical cancer research : CR, Vol. 36, Issue 1, pp. 32, (2017) (PubMed).
Synonymes et noms alternatifs relatifs à EGLN3
egl-9 family hypoxia-inducible factor 3 (egln3), egl-9 family hypoxia inducible factor 3 (EGLN3), egl-9 family hypoxia-inducible factor 3 L homeolog (egln3.L), egl-9 family hypoxia-inducible factor 3 (Egln3), 2610021G09Rik, AI505553, AI648162, EGLN3, Hif-p4h-3, HIFP4H3, HIFPH3, PHD-3, phd3, PHD3, Phd3, SM-20, wu:fj78a08, zgc:77019Protein level used designations for EGLN3
- Hif-p4h-3
- egl nine homolog 3
- phd3
- egl nine homolog 3 (C. elegans)
- HIF-PH3
- HIF-prolyl hydroxylase 3
- HPH-3
- egl nine homolog 3, mitochondrial
- factor-responsive smooth muscle protein
- hypoxia-inducible factor prolyl hydroxylase 3
- prolyl hydroxylase domain-containing protein 3
- HIF prolyl hydroxylase 3
- HPH-1
- egl nine-like protein 3 isoform
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