EIF3E Produits
(Eukaryotic Translation Initiation Factor 3 Subunit E (EIF3E))
Catégories
Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre- initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins. {ECO:0000255|HAMAP-Rule:MF_03004}.
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Catégories EIF3E en vedette
EIF3E Anticorps
High quality antibodies with extensive validation data.
EIF3E Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
EIF3E recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish (Danio rerio)
Application
WB, IHC
Validations
- (5)
N° du produit
ABIN2783260
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Zebrafish (Danio rerio)
Application
WB
Validations
- (5)
- (2)
N° du produit
ABIN1881290
Quantité
400 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (3)
N° du produit
ABIN561508
Quantité
50 μL
Fiche technique
Fiche technique
EIF3E recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1352556
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1352558
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
N° du produit
ABIN2720079
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits EIF3E
: "An oncogenic role of eIF3e/INT6 in human breast cancer." dans: Oncogene, Vol. 29, Issue 28, pp. 4080-9, (2010) (PubMed).: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, (2008) (PubMed).
: "Human INT6/eIF3e is required for nonsense-mediated mRNA decay." dans: EMBO reports, Vol. 8, Issue 6, pp. 596-602, (2007) (PubMed).
: "Reconstitution reveals the functional core of mammalian eIF3." dans: The EMBO journal, Vol. 26, Issue 14, pp. 3373-83, (2007) (PubMed).
: "Mid-region parathyroid hormone-related protein (PTHrP) and gene expression of MDA-MB231 breast cancer cells." dans: Biological chemistry, Vol. 388, Issue 5, pp. 457-65, (2007) (PubMed).
: "A new common integration site, Int7, for the mouse mammary tumor virus in mouse mammary tumors identifies a gene whose product has furin-like and thrombospondin-like sequences." dans: Journal of virology, Vol. 79, Issue 15, pp. 10093-6, (2005) (PubMed).
: "Int6 expression can predict survival in early-stage non-small cell lung cancer patients." dans: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 11, Issue 9, pp. 3198-204, (2005) (PubMed).
: "Fission yeast Int6 is not essential for global translation initiation, but deletion of int6(+) causes hypersensitivity to caffeine and affects spore formation." dans: Molecular biology of the cell, Vol. 11, Issue 11, pp. 4005-18, (2001) (PubMed).
Synonymes et noms alternatifs relatifs à EIF3E
eukaryotic translation initiation factor 3 subunit E (EIF3E), eukaryotic translation initiation factor 3, subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (eif3e), eukaryotic translation initiation factor 3 subunit E L homeolog (eif3e.L), eukaryotic translation initiation factor 3 subunit 6 (LOC692936), eukaryotic translation initiation factor 3 subunit E S homeolog (eif3e.S), eukaryotic translation initiation factor 3, subunit E, a (eif3ea), Eukaryotic translation initiation factor 3 subunit E (eif-3.E), eukaryotic translation initiation factor 3, subunit E, b (eif3eb), eukaryotic translation initiation factor 3 subunit E (Eif3e), eukaryotic translation initiation factor 3 subunit E (LOC108348260), eukaryotic translation initiation factor 3 subunit E (int6), 48kDa, eIF3-p46, EIF3-P48, eIF3-p48, eif3-p48, eIF3-S6, eIF3e, EIF3S6, Eif3s6, eif3s6, eif3s6-A, eif3s6-B, eif3s6b, EIF3SE, im:7147439, INT6, Int6, QtsA-18056Protein level used designations for EIF3E
- eIF-3 p48
- eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E
- eukaryotic translation initiation factor 3, subunit 6 (48kD)
- eukaryotic translation initiation factor 3, subunit 6 48kDa
- mammary tumor-associated protein INT6
- murine mammary tumor integration site 6 (oncogene homolog)
- viral integration site protein INT-6 homolog
- MMTV integration site 6
- mammary tumor integration site 6
- mammary tumor-associated protein INT-6
- viral integration site protein INT-6
- eukaryotic translation initiation factor 3, subunit 6
- eukaryotic translation initiation factor 3 subunit E-A
- Eukaryotic translation initiation factor 3 subunit 6-A
- eukaryotic translation initiation factor 3 subunit E-B
- Eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit E
- Eukaryotic translation initiation factor 3 subunit 6
- eukaryotic translation initiation factor 3 subunit E-like
- eIF3e-B
- eukaryotic translation initiation factor 3 subunit 6-B
- eukaryotic translation initiation factor 3, subunit 6b
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