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ERVW-1 Produits

(Endogenous Retrovirus Group W, Member 1 (ERVW-1))

Catégories

Many different human endogenous retrovirus (HERV) families are expressed in normal placental tissue at high levels, suggesting that HERVs are functionally important in reproduction. This gene is part of an HERV provirus on chromosome 7 that has inactivating mutations in the gag and pol genes. This gene is the envelope glycoprotein gene which appears to have been selectively preserved. The gene's protein product is expressed in the placental syncytiotrophoblast and is involved in fusion of the cytotrophoblast cells to form the syncytial layer of the placenta. The protein has the characteristics of a typical retroviral envelope protein, including a furin cleavage site that separates the surface (SU) and transmembrane (TM) proteins which form a heterodimer. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010].

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Catégories ERVW-1 en vedette

ERVW-1 Anticorps

High quality antibodies with extensive validation data.

ERVW-1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

ERVW-1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7171179
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Application WB
Validations
  • (1)
N° du produit ABIN1537404
Quantité 400 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC
Validations
  • (1)
N° du produit ABIN7239491
Quantité 200 μL
Fiche technique Fiche technique

ERVW-1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
  • (1)
N° du produit ABIN1353105
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits ERVW-1

Ruebner, Langbein, Strissel, Henke, Schmidt, Goecke, Faschingbauer, Schild, Beckmann, Strick: "Regulation of the human endogenous retroviral Syncytin-1 and cell-cell fusion by the nuclear hormone receptors PPAR?/RXR? in placentogenesis." dans: Journal of cellular biochemistry, Vol. 113, Issue 7, pp. 2383-96, (2012) (PubMed).

Holder, Tower, Forbes, Mulla, Aplin, Abrahams: "Immune cell activation by trophoblast-derived microvesicles is mediated by syncytin 1." dans: Immunology, Vol. 136, Issue 2, pp. 184-91, (2012) (PubMed).

Fischer, Weber, Kuhn, Fitzgerald, Schulze, Friese, Walzel, Markert, Jeschke: "Is galectin-1 a trigger for trophoblast cell fusion?: the MAP-kinase pathway and syncytium formation in trophoblast tumour cells BeWo." dans: Molecular human reproduction, Vol. 17, Issue 12, pp. 747-57, (2011) (PubMed).

Ruebner, Strissel, Langbein, Fahlbusch, Wachter, Faschingbauer, Beckmann, Strick: "Impaired cell fusion and differentiation in placentae from patients with intrauterine growth restriction correlate with reduced levels of HERV envelope genes." dans: Journal of molecular medicine (Berlin, Germany), Vol. 88, Issue 11, pp. 1143-56, (2010) (PubMed).

Fischer, Redel, Hofmann, Kuhn, Friese, Walzel, Jeschke: "Stimulation of syncytium formation in vitro in human trophoblast cells by galectin-1." dans: Placenta, Vol. 31, Issue 9, pp. 825-32, (2010) (PubMed).

Synonymes et noms alternatifs relatifs à ERVW-1

endogenous retrovirus group W member 1, envelope (ERVW-1), ENV, ENVW, ERVWE1, HERV-7q, HERV-W-ENV, HERV7Q, HERVW, HERVWENV

Protein level used designations for ERVW-1

  • HERV-7q envelope protein
  • HERV-W Env glycoprotein
  • HERV-W envelope protein
  • HERV-W_7q21.2 provirus ancestral Env polyprotein
  • HERV-W{7q21.1} provirus ancestral Env polyprotein
  • HERV-tryptophan envelope protein
  • endogenous retroviral family W, env(C7), member 1
  • endogenous retrovirus group W member 1
  • env-W
  • envelope glycoprotein
  • envelope polyprotein gPr73
  • envelope protein
  • enverin
  • human endogenous retrovirus W envC7-1 envelope protein
  • syncytin A
  • syncytin-1
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