EWSR1 Produits
(Ewing Sarcoma Breakpoint Region 1 (EWSR1))
Catégories
This gene encodes a multifunctional protein that is involved in various cellular processes, including gene expression, cell signaling, and RNA processing and transport. The protein includes an N-terminal transcriptional activation domain and a C-terminal RNA-binding domain. Chromosomal translocations between this gene and various genes encoding transcription factors result in the production of chimeric proteins that are involved in tumorigenesis. These chimeric proteins usually consist of the N-terminal transcriptional activation domain of this protein fused to the C-terminal DNA-binding domain of the transcription factor protein. Mutations in this gene, specifically a t(11\;22)(q24\;q12) translocation, are known to cause Ewing sarcoma as well as neuroectodermal and various other tumors. Alternative splicing of this gene results in multiple transcript variants. Related pseudogenes have been identified on chromosomes 1 and 14. [provided by RefSeq, Jul 2009].
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Catégories EWSR1 en vedette
EWSR1 Anticorps
High quality antibodies with extensive validation data.
EWSR1 Kits ELISA
Reliable ELISA kits for a wide range of species.
EWSR1 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
EWSR1 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
- (6)
N° du produit
ABIN335135
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC (p)
Validations
- (4)
N° du produit
ABIN560815
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat
Application
WB, IHC
Validations
- (5)
N° du produit
ABIN2779045
Quantité
100 μL
Fiche technique
Fiche technique
EWSR1 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Analytical Method
Validations
N° du produit
ABIN1156238
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Mouse
Analytical Method
Validations
N° du produit
ABIN1156239
Quantité
96 tests
Fiche technique
Fiche technique
EWSR1 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1353206
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
HEK-293 Cells
Validations
- (1)
- (1)
N° du produit
ABIN2720598
Quantité
20 μg
Fiche technique
Fiche technique
Dernières publications sur nos produits EWSR1
: "Liquid demixing of intrinsically disordered proteins is seeded by poly(ADP-ribose)." dans: Nature communications, Vol. 6, pp. 8088, (2015) (PubMed).: "Accumulation of pre-let-7g and downregulation of mature let-7g with the depletion of EWS." dans: Biochemical and biophysical research communications, Vol. 426, Issue 1, pp. 89-93, (2012) (PubMed).
: "Oncoprotein EWS-FLI1 activity is enhanced by RNA helicase A." dans: Cancer research, Vol. 66, Issue 11, pp. 5574-81, (2006) (PubMed).
: "Oncogenic MITF dysregulation in clear cell sarcoma: defining the MiT family of human cancers." dans: Cancer cell, Vol. 9, Issue 6, pp. 473-84, (2006) (PubMed).
Synonymes et noms alternatifs relatifs à EWSR1
EWS RNA binding protein 1 (EWSR1), Ewing sarcoma breakpoint region 1 (Ewsr1), EWS RNA-binding protein 1 (Ewsr1), EWS RNA-binding protein 1a (ewsr1a), EWS RNA binding protein 1 (ewsr1), EWS RNA binding protein 1 (Ewsr1), EWS RNA binding protein 1 L homeolog (ewsr1.L), EWS RNA-binding protein 1b (ewsr1b), AU018891, bK984G1.4, DKFZp459K1116, EWS, Ews, Ewsh, EWSR1, ewsr1, ewsr1.S, fb40b11, fc04c01, fusl, wu:fb40b11, wu:fb75g09, wu:fc04c01, zgc:55864Protein level used designations for EWSR1
- Ewing sarcoma breakpoint region 1
- Ewings sarcoma EWS-Fli1 (type 1) oncogene
- RNA-binding protein EWS
- Ewing sarcoma homolog
- Ewing sarcoma RNA-binding protein
- EWS RNA binding protein 1 S homeolog
- uncharacterized protein LOC734969
- Ewing sarcoma breakpoint region 1b
- fusion, derived from t(12;16) malignant liposarcoma, like
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