Factor 12 Heavy Chain Anticorps
(Factor 12 Heavy Chain (F12))
This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI. Defects in this gene do not cause any clinical symptoms and the sole effect is that whole-blood clotting time is prolonged. [provided by RefSeq, Jul 2008].
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Catégories Factor 12 Heavy Chain en vedette
Factor 12 Heavy Chain Anticorps
High quality antibodies with extensive validation data.
Factor 12 Heavy Chain recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human, Mouse, Rat
Application
WB, IF (p), IHC (p)
Validations
- (2)
N° du produit
ABIN1387090
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA
Validations
- (1)
N° du produit
ABIN3181837
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human
Application
WB, ELISA, IHC
Validations
N° du produit
ABIN3181836
Quantité
100 μL
Fiche technique
Fiche technique
Synonymes et noms alternatifs relatifs à Factor 12 Heavy Chain
coagulation factor XII (F12), coagulation factor XII (Hageman factor) (F12), FXII, HAE3, HAEX, HAFProtein level used designations for Factor 12 Heavy Chain
- coagulation factor XII
- factor XII
- hageman factor
- Hageman factor
- beta-factor XIIa part 1
- beta-factor XIIa part 2
- coagulation factor XIIa heavy chain
- coagulation factor XIIa light chain
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