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FANCL Produits

(Fanconi Anemia, Complementation Group L (FANCL))

Catégories

The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity\; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group L. Alternative splicing results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008].

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Catégories FANCL en vedette

FANCL Anticorps

High quality antibodies with extensive validation data.

FANCL Kits ELISA

Reliable ELISA kits for a wide range of species.

FANCL Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

FANCL recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Application WB, IF, IP
Validations
  • (6)
N° du produit ABIN949415
Quantité 100 μL
Fiche technique Fiche technique
Reactivity Human, Mouse
Application WB, IHC
Validations
  • (3)
N° du produit ABIN7262741
Quantité 200 μL
Fiche technique Fiche technique
Reactivity Human
Application ELISA, IHC, IF
Validations
  • (2)
N° du produit ABIN7151021
Quantité 100 μg
Fiche technique Fiche technique

FANCL recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method
Validations
N° du produit ABIN1131086
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method
Validations
N° du produit ABIN1131087
Quantité 96 tests
Fiche technique Fiche technique

FANCL recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353638
Quantité 10 μg
Fiche technique Fiche technique
Reactivity Human
Source Baculovirus infected Insect Cells, Insect cells (Sf9)
Validations
N° du produit ABIN6699823
Quantité 50 μg
Fiche technique Fiche technique

Dernières publications sur nos produits FANCL

Panneerselvam, Pickering, Han, Li, Zheng, Zhang, Zhang, Fei: "Basal level of FANCD2 monoubiquitination is required for the maintenance of a sufficient number of licensed-replication origins to fire at a normal rate." dans: Oncotarget, Vol. 5, Issue 5, pp. 1326-37, (2014) (PubMed).

Zhang, Zhao, Park, Wang, Dyer, Liu, Klee, McNiven, Tindall, Molina, Fei: "FAVL elevation in human tumors disrupts Fanconi anemia pathway signaling and promotes genomic instability and tumor growth." dans: The Journal of clinical investigation, Vol. 120, Issue 5, pp. 1524-34, (2010) (PubMed).

García, Fernández, Osorio, Barroso, Fernández, Urioste, Benítez et al.: "Mutational analysis of FANCL, FANCM and the recently identified FANCI suggests that among the 13 known Fanconi Anemia genes, only FANCD1/BRCA2 plays a major role in high-risk breast cancer ..." dans: Carcinogenesis, Vol. 30, Issue 11, pp. 1898-902, (2009) (PubMed).

Longerich, San Filippo, Liu, Sung: "FANCI binds branched DNA and is monoubiquitinated by UBE2T-FANCL." dans: The Journal of biological chemistry, Vol. 284, Issue 35, pp. 23182-6, (2009) (PubMed).

McWilliams, Bamlet, de Andrade, Rider, Couch, Cunningham, Matsumoto, Rabe, Hammer, Petersen: "Polymorphic variants in hereditary pancreatic cancer genes are not associated with pancreatic cancer risk." dans: Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology, Vol. 18, Issue 9, pp. 2549-52, (2009) (PubMed).

Hess, Ameziane, Schuurhuis, Errami, Denkers, Kaspers, Cloos, Joenje, Reinhardt, Ossenkoppele, Zwaan, Waisfisz: "Hypermethylation of the FANCC and FANCL promoter regions in sporadic acute leukaemia." dans: Cellular oncology : the official journal of the International Society for Cellular Oncology, Vol. 30, Issue 4, pp. 299-306, (2008) (PubMed).

Synonymes et noms alternatifs relatifs à FANCL

Fanconi anemia complementation group L (FANCL), Fanconi anemia, complementation group L (Fancl), 2010322C19Rik, AW554273, B230118H11Rik, FAAP43, gcd, PHF9, Phf9, POG, Pog

Protein level used designations for FANCL

  • E3 ubiquitin-protein ligase FANCL
  • PHD finger protein 9
  • fanconi anemia group L protein
  • fanconi anemia-associated polypeptide of 43 kDa
  • fanconi anemia group L protein homolog
  • germ cell deficient
  • proliferation of germ cells protein
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