This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of the ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. This protein is similar to xenopus early mitotic inhibitor-1 (Emi1), which is a mitotic regulator that interacts with Cdc20 and inhibits the anaphase promoting complex. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Dec 2008].
antibodies-online.com est synonyme de produits de recherche de haute qualité. Cherchez, trouvez et commandez des outils avec des données de validation étendues, des images, des références. Notre service clientèle scientifique est toujours à votre disposition si vous avez des questions sur la sélection ou l'application de nos produits.
Dernières publications sur nos produits F-Box Protein 5
Marzio, Puccini, Kwon, Maverakis, Arbini, Sung, Bar-Sagi, Pagano: "The F-Box Domain-Dependent Activity of EMI1 Regulates PARPi Sensitivity in Triple-Negative Breast Cancers." dans: Molecular cell, Vol. 73, Issue 2, pp. 224-237.e6, (2019) (PubMed).
Estrabaud, Le Rouzic, Lopez-Vergès, Morel, Belaïdouni, Benarous, Transy, Berlioz-Torrent, Margottin-Goguet: "Regulated degradation of the HIV-1 Vpu protein through a betaTrCP-independent pathway limits the release of viral particles." dans: PLoS pathogens, Vol. 3, Issue 7, pp. e104, (2007) (PubMed).
Synonymes et noms alternatifs relatifs à F-Box Protein 5
F-box protein 5 (FBXO5), F-box protein 5 (Fbxo5), F-box protein 5 (fbxo5), F-box only protein 5 (Fbxo5), F-box protein 5 L homeolog (fbxo5.L), F-box protein 5 S homeolog (fbxo5.S), 2510044I10Rik, ACYPI007854, C85305, EMI1, Emi1, emi1, FBX5, fbx5, Fbxo5, fbxo5, Fbxo31, fc65h02, wu:fc65h02, wu:fe06e07, wu:fz79f03, zgc:136397, zgc:158541
Protein level used designations for F-Box Protein 5