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F2RL1 Produits

(Coagulation Factor II (thrombin) Receptor-Like 1 (F2RL1))
Coagulation factor II (thrombin) receptor-like 1 (F2RL1) is a member of the large family of 7-transmembrane-region receptors that couple to guanosine-nucleotide-binding proteins. F2RL1 is also a member of the protease-activated receptor family. It is activated by trypsin, but not by thrombin. It is activated by proteolytic cleavage of its extracellular amino terminus. The new amino terminus functions as a tethered ligand and activates the receptor. The F2RL1 gene contains two exons and is widely expressed in human tissues. The predicted protein sequence is 83% identical to the mouse receptor sequence. [provided by RefSeq, Jul 2008].

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Catégories F2RL1 en vedette

F2RL1 Anticorps

High quality antibodies with extensive validation data.

F2RL1 Kits ELISA

Reliable ELISA kits for a wide range of species.

F2RL1 Protéines

Proteins for various applications incl. WB, ELISA, IF etc.

F2RL1 recommandé Anticorps

Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human, Mouse, Rat
Application WB, IHC, IF, ICC
Validations
  • (5)
N° du produit ABIN7043075
Quantité 25 μL
Fiche technique Fiche technique
Reactivity Human
Application WB, IHC
Validations
  • (3)
N° du produit ABIN7101760
Quantité 20 μL
Fiche technique Fiche technique
Reactivity Human, Monkey
Application IHC, IHC (p)
Validations
  • (3)
N° du produit ABIN1049232
Quantité 50 μg
Fiche technique Fiche technique

F2RL1 recommandé Kits ELISA

Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Analytical Method Quantitative Sandwich ELISA
Validations
  • (6)
  • (1)
N° du produit ABIN6954858
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Mouse
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965879
Quantité 96 tests
Fiche technique Fiche technique
Reactivity Rat
Analytical Method Quantitative Sandwich ELISA
Validations
  • (1)
N° du produit ABIN6965880
Quantité 96 tests
Fiche technique Fiche technique

F2RL1 recommandé Protéines

Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity Human
Source HEK-293 Cells
Validations
  • (2)
N° du produit ABIN7491637
Quantité 100 μg
Fiche technique Fiche technique
Reactivity Human
Source Escherichia coli (E. coli)
Validations
  • (1)
N° du produit ABIN7122416
Quantité 50 μg
Fiche technique Fiche technique
Reactivity Human
Source Wheat germ
Validations
  • (1)
N° du produit ABIN1353314
Quantité 10 μg
Fiche technique Fiche technique

Dernières publications sur nos produits F2RL1

Klinngam, Fu, Janga, Edman, Hamm-Alvarez: "Cathepsin S Alters the Expression of Pro-Inflammatory Cytokines and MMP-9, Partially through Protease-Activated Receptor-2, in Human Corneal Epithelial Cells." dans: International journal of molecular sciences, Vol. 19, Issue 11, (2019) (PubMed).

Cheng, Fiez-Vandal, Schlenker, Edman, Aggeler, Brown, Brown, Cooke, Dumelin, Doré, Geschwindner, Grebner, Hermansson, Jazayeri, Johansson, Leong, Prihandoko, Rappas, Soutter, Snijder, Sundström et al.: "Structural insight into allosteric modulation of protease-activated receptor 2. ..." dans: Nature, Vol. 545, Issue 7652, pp. 112-115, (2017) (PubMed).

Quanjun, Qingyu, Qiliang, Liqun, Jinmei, Ziquan, Shike: "Effect and mechanism of PAR-2 on the proliferation of esophageal cancer cells." dans: European review for medical and pharmacological sciences, Vol. 20, Issue 22, pp. 4688-4696, (2017) (PubMed).

Kouzaki, Matsumoto, Kato, Tojima, Shimizu, Shimizu: "Epithelial Cell-Derived Cytokines Contribute to the Pathophysiology of Eosinophilic Chronic Rhinosinusitis." dans: Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research, Vol. 36, Issue 3, pp. 169-79, (2016) (PubMed).

Pan, Zhang, Zang, Tan, Jin: "Hydroxysafflor yellow A inhibits TGF-β1-induced activation of human fetal lung fibroblasts in vitro." dans: The Journal of pharmacy and pharmacology, Vol. 68, Issue 10, pp. 1320-30, (2016) (PubMed).

Rohan, Smetakova, Kukal, Rusina, Matej: "Proteinase-activated receptor 2 and disease biomarkers in cerebrospinal fluid in cases with autopsy-confirmed prion diseases and other neurodegenerative diseases." dans: BMC neurology, Vol. 15, pp. 50, (2015) (PubMed).

Viodé, Lejeune, Turlier, Rouquier, Casas, Mengeaud, Redoulès, Schmitt: "Cathepsin S, a new pruritus biomarker in clinical dandruff/seborrhoeic dermatitis evaluation." dans: Experimental dermatology, Vol. 23, Issue 4, pp. 274-5, (2014) (PubMed).

Mat?j, Sm?táková, Vašáková, Nováková, Sterclová, Kukal, Olejár: "PAR-2, IL-4R, TGF-? and TNF-? in bronchoalveolar lavage distinguishes extrinsic allergic alveolitis from sarcoidosis." dans: Experimental and therapeutic medicine, Vol. 8, Issue 2, pp. 533-538, (2014) (PubMed).

Vasakova, Sterclova, Stranska, Mandakova, Skibova, Matej: "Biomarkers of fibroproliferative healing in fibrosing idiopathic interstitial pneumonias." dans: The open respiratory medicine journal, Vol. 6, pp. 160-4, (2013) (PubMed).

Yau, Liu, Fairlie: "Toward drugs for protease-activated receptor 2 (PAR2)." dans: Journal of medicinal chemistry, Vol. 56, Issue 19, pp. 7477-97, (2013) (PubMed).

Synonymes et noms alternatifs relatifs à F2RL1

Proteinase-activated receptor 2 (par2), F2R like trypsin receptor 1 (F2RL1), coagulation factor II (thrombin) receptor-like 1 (F2rl1), F2R like trypsin receptor 1 (F2rl1), Gpcr11, GPR11, PAR-2, Par-2, par2, PAR2, Par2

Protein level used designations for F2RL1

  • Proteinase-activated receptor 2
  • G-protein coupled receptor 11
  • coagulation factor II receptor-like 1
  • protease-activated receptor 2
  • proteinase-activated receptor 2
  • thrombin receptor-like 1
  • Protease-activated receptor-2
  • proteinase-activated receptor-2
  • Proteinase-activated receptor-2 G protein-coupled receptor 11
  • Proteinase-activated receptor-2, G protein-coupled receptor 11
  • PAR-2
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