FBXO11 Produits
(F-Box Protein 11 (FBXO11))
Catégories
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbxs class. It can function as an arginine methyltransferase that symmetrically dimethylates arginine residues, and it acts as an adaptor protein to mediate the neddylation of p53, which leads to the suppression of p53 function. This gene is known to be down-regulated in melanocytes from patients with vitiligo, a skin disorder that results in depigmentation. Polymorphisms in this gene are associated with chronic otitis media with effusion and recurrent otitis media (COME/ROM), a hearing loss disorder, and the knockout of the homologous mouse gene results in the deaf mouse mutant Jeff (Jf), a single gene model of otitis media. Alternatively spliced transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jun 2010].
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Catégories FBXO11 en vedette
FBXO11 Anticorps
High quality antibodies with extensive validation data.
FBXO11 Kits ELISA
Reliable ELISA kits for a wide range of species.
FBXO11 Protéines
Proteins for various applications incl. WB, ELISA, IF etc.
FBXO11 recommandé Anticorps
Produit
Reactivity
Application
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Application
WB, ELISA, IF, IHC (p)
Validations
- (4)
N° du produit
ABIN566432
Quantité
100 μg
Fiche technique
Fiche technique
Reactivity
Human
Application
ELISA, IF (cc), IF (p), IHC (p), IHC (fro)
Validations
- (2)
N° du produit
ABIN1386847
Quantité
100 μL
Fiche technique
Fiche technique
Reactivity
Human, Mouse
Application
WB, IF
Validations
- (2)
N° du produit
ABIN7261998
Quantité
200 μL
Fiche technique
Fiche technique
FBXO11 recommandé Kits ELISA
Produit
Reactivity
Analytical Method
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Sheep
Analytical Method
Validations
N° du produit
ABIN1773981
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Human
Analytical Method
Quantitative Competition ELISA
Validations
N° du produit
ABIN1743076
Quantité
96 tests
Fiche technique
Fiche technique
Reactivity
Dog
Analytical Method
Validations
N° du produit
ABIN1769085
Quantité
96 tests
Fiche technique
Fiche technique
FBXO11 recommandé Protéines
Produit
Reactivity
Source
Validations
N° du produit
Quantité
Fiche technique
Reactivity
Human
Source
Wheat germ
Validations
- (1)
N° du produit
ABIN1353767
Quantité
10 μg
Fiche technique
Fiche technique
Reactivity
Human
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3089172
Quantité
1 mg
Fiche technique
Fiche technique
Reactivity
Mouse
Source
Tobacco (Nicotiana tabacum)
Validations
N° du produit
ABIN3121953
Quantité
1 mg
Fiche technique
Fiche technique
Dernières publications sur nos produits FBXO11
: "Cyclin F Controls Cell-Cycle Transcriptional Outputs by Directing the Degradation of the Three Activator E2Fs." dans: Molecular cell, Vol. 74, Issue 6, pp. 1264-1277.e7, (2019) (PubMed).: "Degradation of Cep68 and PCNT cleavage mediate Cep215 removal from the PCM to allow centriole separation, disengagement and licensing." dans: Nature cell biology, Vol. 17, Issue 1, pp. 31-43, (2014) (PubMed).
: "DRE-1/FBXO11-dependent degradation of BLMP-1/BLIMP-1 governs C. elegans developmental timing and maturation." dans: Developmental cell, Vol. 28, Issue 6, pp. 697-710, (2014) (PubMed).
: "Regulation of the CRL4(Cdt2) ubiquitin ligase and cell-cycle exit by the SCF(Fbxo11) ubiquitin ligase." dans: Molecular cell, Vol. 49, Issue 6, pp. 1159-66, (2013) (PubMed).
: "FBXO11 targets BCL6 for degradation and is inactivated in diffuse large B-cell lymphomas." dans: Nature, Vol. 481, Issue 7379, pp. 90-3, (2012) (PubMed).
: "Synthetic heterovalent inhibitors targeting recognition E3 components of the N-end rule pathway." dans: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 1, pp. 100-5, (2008) (PubMed).
Synonymes et noms alternatifs relatifs à FBXO11
F-box protein 11 (FBXO11), F-box protein 11 (Fbxo11), F-box protein 11 L homeolog (fbxo11.L), F-box protein 11a (fbxo11a), F-box only protein 11 (CpipJ_CPIJ009919), F-box only protein 11 (CpipJ_CPIJ017549), F-box only protein 11 (Bm1_52225), hypothetical protein (LOAG_16571), F-box protein 11 (fbxo11), F-box protein 11 (LOC100115478), C80048, DKFZp459P2410, FBX11, fbxo11, FBXO11, Fbxo11, im:6906507, Jf, MGC84634, PRMT9, UBR6, VIT1, Vit1, wu:fj83f06, zgc:153171Protein level used designations for FBXO11
- F-box only protein 11
- protein arginine N-methyltransferase 9
- ubiquitin protein ligase E3 component n-recognin 6
- vitiligo-associated protein 1
- vitiligo-associated protein VIT-1
- GENA 104
- jeff
- F-box protein 11
- fj83f06
- F-box only protein 11-like
- f-box only protein 11-like
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