This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012].
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Khan, Muzumdar, Shiras: "Attenuation of Tumor Suppressive Function of FBXO16 Ubiquitin Ligase Activates Wnt Signaling In Glioblastoma." dans: Neoplasia (New York, N.Y.), Vol. 21, Issue 1, pp. 106-116, (2019) (PubMed).
Synonymes et noms alternatifs relatifs à FBXO16
F-box protein 16 (FBXO16), F-box protein 16 (LOC100150082), F-box protein 16 (fbxo16), F-box protein 16 (Fbxo16), 4932435C24Rik, FBX16, Fbx16, si:ch211-89p3.1, zgc:112464